Protein designer, cryoEMer, scientist at Arzeda. Views are my own. 🧉
San Diego, CA
Joined December 2010
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I'm happy to share the publication of my postdoctoral work at the @LanderLab. We solved previously-unobserved conformations of human TTR, an 55kDa amyloid-forming protein, to great resolution. #CryoEM
biorxiv.org/content/10.1101/…
Benjamin Basanta 🧉 retweeted
No se pierdan el deadline para enviar sus Abstracts!!!
💥 2026 A2B2C CONFERENCE #XVCAB2C
📣 We are thrilled to unveil this year's official conference program!
🗓️ Submit your abstract !! Deadline October 1st !
📌 November 9-12, 2026
👉 More info: 2026.a2b2c.org.ar
Benjamin Basanta 🧉 retweeted
The UW Institute for Protein Design (IPD) is hiring an Analytical Methods and Instrumentation Scientist!
uw.wd5.myworkdayjobs.com/en-…
Benjamin Basanta 🧉 retweeted
Big news: MANE has acquired the exclusive global license to produce and commercialize Arzeda’s ViaLeaf™ Reb M. Together, we’re accelerating global access to a scalable, great-tasting solution for natural sugar reduction.
prnewswire.com/news-releases…
Benjamin Basanta 🧉 retweeted
De novo designed oligomers that respond to copper, small molecules, and phosphorylation...
Using a single design strategy? 🧬⚙️
🎉
Excited to share our new bioRxiv preprint—a collaboration between the Khmelinskaia, Correia, Schoeder and a Tinnefeld labs!
biorxiv.org/content/10.64898…
Benjamin Basanta 🧉 retweeted
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Benjamin Basanta 🧉 retweeted
Preprint alert: Our work with the Greenberg lab is now in bio archives! Dream collaboration with the amazing Erin Duffy in which we show that RNA stability modulation is a major component of neural activity gene regulation. See bellow our x-plainer (formerly known as tweetorial)
Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below 👇 biorxiv.org/content/10.1101/… (1/11)
Benjamin Basanta 🧉 retweeted
Delighted to share that our cryo-EM work with @inmunova on engineered immunogens capable of eliciting neutralizing antibodies against hemolytic uremic syndrome is featured on the cover of Protein Science!
🔗 doi.org/10.1002/pro.70178
Benjamin Basanta 🧉 retweeted
The human mitochondrial ClpXP is uniquely assembled and regulated compared to its bacterial counterparts. Congrats to Kelly Chen on her years of hard work on this challenging complex! biorxiv.org/content/10.1101/…
Benjamin Basanta 🧉 retweeted
Huge congratulations to David Baker, Arzeda Co-Founder and Scientific Advisor, for being awarded the 2024 Nobel Prize in Chemistry! 🏆
Arzeda is the first protein design company to emerge from David's lab, contributing to breakthroughs in the field.
nobelprize.org/prizes/chemis…
Benjamin Basanta 🧉 retweeted
This is a huge validation of the importance of protein design. Arzeda cofounder David Baker is a gratifying choice. This signals the arrival of protein design as a fundamental tool in chemistry. I spent my PhD working on enzyme design.. and look where we are now!
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Benjamin Basanta 🧉 retweeted
Come be my colleague! UW Tacoma is hiring an Assistant Professor of Biochemistry. We're looking for someone excited about mentoring undergraduates in research, inclusive teaching, and being part of an interdisciplinary community of scholars. apply.interfolio.com/154390
Benjamin Basanta 🧉 retweeted
Big News! Arzeda has closed a $38M oversubscribed funding round! This investment was led by top investors like @SofinnovaVC, @FallLineCapital, and & W.L. Gore & Associates
tinyurl.com/bdemjjeh
Benjamin Basanta 🧉 retweeted
Some thoughts on the current state of single particle cryo-EM map/model validation. (TLDR: preferred orientation remains a big problem, ❤️ Q-scores. There's been progress, but there's still more to do. ) authors.elsevier.com/sd/arti…
Benjamin Basanta 🧉 retweeted
Excited to share that I am starting a lab focused on deep learning-based protein design, biophysics and fundamental biology at @MPI_Biochem and @GeneCenter_LMU in Munich with the Emmy Noether Programme this summer. Join us as a PhD or postdoc. More to follow soon!
Benjamin Basanta 🧉 retweeted
New paper published in formal journal ! With @nachoquique
and @eagalpern we explore the possibility of existence of extraterrestrial proteins. In sum: likelly!
pnas.org/doi/10.1073/pnas.23…
Benjamin Basanta 🧉 retweeted
Finally our work on designing pH responsive antibody nanoparticles capable of disassembling at ~tunable~ pH, packaging and releasing cargo, and targeting specific cell surface receptors is out in @NatureSMB! nature.com/articles/s41594-0…
Benjamin Basanta 🧉 retweeted
Our first foray into the fascinating field of DNA repair! Congrats to postdoc Chris Zerio @chriszerio, who tested hundreds of oligos to identify one that trapped the helicase of human Polymerase θ in the process of annealing two strands of DNA. tinyurl.com/jaddar9u
Benjamin Basanta 🧉 retweeted
Thrilled to share my postdoctoral work in @Landerlab! The human Polymerase θ helicase undergoes conformational rearrangements to facilitate DNA microhomology annealing. These insights enable rational design of novel BRCA-deficient cancer therapeutics! tinyurl.com/jaddar9u
Hey @Moto_Support how can I get a replacement for my modem that is still in warranty? The app doesn't work, both of your phone lines are constantly busy, I can't even dm you. Posting at support is all I can do. Seriously?