@BeiselLab

Synthetic Biology lab of Chase Beisel at @Helmholtz_HIRI. Lab logo designed by our own PhD student, Adini Arifah!

 Würzburg, DE
helmholtz-hiri.de
Joined February 2022
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  • Followers646
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Excited to share our work published in @NatureBiotech! We uncover and characterize a unique and highly versatile ancestral form of CRISPR-Cas12a (ReChb)! A big thanks to the whole team. 🧬 nature.com/articles/s41587-0… #SynBioLab @CICbioGUNE @IgorTascon @BeiselLab @FUNDELA1
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A new research briefing has just been published in @NatureBiotech, summarizing the latest paper from #HIRI's @BeiselLab in collaboration with @YleniaJabalera and Raúl Pérez Jiménez from @CICbioGUNE. Check it out! ⤵️
Nature Biotechnology
@NatureBiotech6 Nov 2024
Replying to @NatureBiotech @CICbioGUNE @basque_for @Helmholtz_HIRI @BRforEM @YleniaJabalera @BeiselLab @IgorTascon
Research Briefing: Ancient and versatile CRISPR–Cas nuclease created with ancestral sequence reconstruction go.nature.com/3ChzwG3
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Happy to have been able to contribute to the implementation of this exciting new genome editing tool coming out of the Chase Biesel lab! @BeiselLab Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in eukaryotes biorxiv.org/content/10.1101/…

Targeted DNA ADP-ribosylation triggers templated repair in bacteria and base mutagenesis in...

Base editors create precise genomic edits by directing nucleobase deamination or removal without inducing double-stranded DNA breaks. However, a vast chemical space of other DNA modifications remains...

biorxiv.org
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Exciting stuff happening in microbiome science! Check out Charlotte Kamm's Spotlight article on engineering bacteriophages to deliver gene editors.
Charlotte Kamm@LK760653179378614 Sep 2024
In my publishing my first Spotlight article era ✨️ @BeiselLab
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In my publishing my first Spotlight article era ✨️ @BeiselLab
Trends in Microbiology@TrendsMicrobiol14 Sep 2024
Phages to the rescue: in situ editing of the gut microbiota dlvr.it/TDF5x9
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Check out the exciting work of @Chunlei_Jiao on the PUMA technology for the precise detection of RNA with DNA-cutting Cas12 nucleases
Helmholtz Institute Würzburg (HIRI)@Helmholtz_HIRI16 Jul 2024
#CRISPRCas systems have become a plentiful source of technologies for molecular diagnostics. #HIRI’s @BeiselLab has now expanded this extensive toolbox. PUMA enables the detection of RNA with Cas12 nucleases, which naturally target DNA. 🧬🐈🧵 Read more: helmholtz-hiri.de/en/newsroo…
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#CRISPRCas systems have become a plentiful source of technologies for molecular diagnostics. #HIRI’s @BeiselLab has now expanded this extensive toolbox. PUMA enables the detection of RNA with Cas12 nucleases, which naturally target DNA. 🧬🐈🧵 Read more: helmholtz-hiri.de/en/newsroo…
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Exciting advance addressing a long-standing challenge: efficiently transforming DNA! Congrats to Justin Vento on his new paper introducing IMPRINT. @Helmholtz_HIRI @ncstatecbe doi.org/10.1016/j.molcel.202…
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Our brilliant team member, @Chunlei_Jiao will start a new adventure with his own lab at NUS in Singapore next year! A huge congratulations to him on this achievement. #CRISPR #PostdocPositions #PhDPositions
Chunlei Jiao@Chunlei_Jiao9 Dec 2023
Job Alerts, thrilled to announce that I will join NUS in Singapore in July 2024! 2 Postdoc and 4 fully-funded PhD positions available. Join me in this beautiful and vibrant place for #CRISPR and beyond research! If interested, email me or DM. Please RT!!!
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(1/2) 🚨 Check out @BeiselLab’s recent work in @NAR_Open reporting new Anti-CRISPR proteins. They were discovered in a bacterial #pathogen with two extensively self-targeting Type I #CRISPR-Cas systems, and the Acrs block #DNA degradation but not DNA binding.
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(2/2) For those and many more intriguing findings, including unexpected homologs, see 👇academic.oup.com/nar/advance…

Interrogating two extensively self-targeting Type I CRISPR-Cas systems in Xanthomonas albilineans...

Abstract. CRISPR-Cas systems store fragments of invader DNA as spacers to recognize and clear those same invaders in the future. Spacers can also be acquir

academic.oup.com
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Such as pleasure to host @BeiselLab as a #ChafferFellow @otago @microtago. An amazing tour de force talk today titled “#CRISPR: a bottomless well of discovery and innovation”
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Having trouble with transforming your favorite bacteria with valuable genetic cargo? Try IMPRINT🙌🏻! A sophisticated TXTL-based pipeline developed by @JustinVento @BeiselLab Fun and long-lasting collaboration between @nathanguy14 @BeiselLab members! Grateful to be part of it☺️
bioRxiv@biorxivpreprint17 Sep 2023
A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria biorxiv.org/cgi/content/shor… #bioRxiv
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A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria biorxiv.org/cgi/content/shor… #bioRxiv
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Listen up, #CRISPR Fan(zor)atics! ✂️🧬 In a new @MolecularCell spotlight, @BeiselLab's @copa_bio recaps @zhangf's recent remarkable discovery describing eukaryotic #RNA-guided DNA endonucleases, called Fanzors. Read more here: authors.elsevier.com/a/1hjJC…
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#CRISPR arrays are a compact way for nature to encode #gRNAs, but their ability to acquire new spacers keeps them longer than necessary for CRISPR technologies. #HIRI's @BeiselLab now shows that CRISPR-Cas9 arrays can be shortened without compromising: doi.org/10.1080/15476286.202…

Shortened CRISPR-Cas9 arrays enable multiplexed gene targeting in bacteria from a smaller DNA...

CRISPR technologies comprising a Cas nuclease and a guide RNA (gRNA) can utilize multiple gRNAs to enact multi-site editing or regulation in the same cell. Nature devised a highly compact means of ...

tandfonline.com
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Great way to round out @crispr2023 #crispr with the conference dinner at the Wurzburg Residence!
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Did you enjoy @crispr2023 or want to come to the next one! The #crispr conference will be in ⁦@Christchurch_NZ⁩ organised by ⁦@PeterFineran⁩, ⁦@dsashital⁩ ⁦@gavinjknott⁩ and ⁦@drbridgetwatson⁩. Check out the website crispr2025.org
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Our postdoc @Chunlei_Jiao presented his recent findings at #CRISPR2023 today. If you have the chance also look at posters number 41, 43, and 48 from other lab members @katwandu @AngelaMigur @Okrety_MD
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Super excited to kick off #CRISPR2023 with our keynote speaker Virginijus Šikšnys! #conferencevibes @Helmholtz_HIRI @Uni_WUE
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