Begin Health | For baby + kids' microbiome health https://xitter.cf/t.co/jqCw0nErpo ๐Ÿ‘ถ๐Ÿปโค๏ธ๐Ÿ’ฉ gut health is #kidshealth

San Francisco
Joined April 2020
Yesterday, @WSJ featured @GetTinyHealth in a piece on the rise of baby microbiome testing, alongside our friends @BeginHealth and @MadelineZephyr. The headline: โ€œ๐—•๐—ฎ๐—ฏ๐—ถ๐—ฒ๐˜€โ€™ ๐—š๐˜‚๐˜ ๐—›๐—ฒ๐—ฎ๐—น๐˜๐—ต ๐—œ๐˜€ ๐˜๐—ต๐—ฒ ๐—ก๐—ฒ๐˜„ ๐—ข๐—ฏ๐˜€๐—ฒ๐˜€๐˜€๐—ถ๐—ผ๐—ป ๐—ณ๐—ผ๐—ฟ ๐—ฃ๐—ฎ๐—ฟ๐—ฒ๐—ป๐˜๐˜€ โ€“ ๐—ฎ๐—ป๐—ฑ ๐—ฆ๐˜๐—ฎ๐—ฟ๐˜๐˜‚๐—ฝ๐˜€.โ€ Yes, we absolutely are obsessed โ€“ as founders building in this space and as parents thinking deeply about the world our children are growing up in. Because nearly 1 in 2 children in the U.S. now has a chronic condition, per the CDC. Somehow, this has been framed as the status quo. Itโ€™s insane. We cannot accept this. Eczema. Food allergies. Asthma. Autoimmune disease. If the immune system is trained in the first 1,000 days of life โ€” and the microbiome plays a central role in that training โ€” why wouldnโ€™t we prioritize getting that foundation right? The article opens with Brittany and her son Leo, who was struggling with constipation, fussiness, and poor weight gain early on. Like many parents, she wasnโ€™t looking for a trend. She was looking for answers. As part of their Tiny Health journey, recommendations included outdoor play, pet exposure, and increasing microbial diversity. Thatโ€™s not trend-driven advice. Itโ€™s grounded in decades of immunology research. In the first year of life, babies exposed to farms, animals, and pets develop higher levels of beneficial microbes like ๐˜‰๐˜ช๐˜ง๐˜ช๐˜ฅ๐˜ฐ๐˜ฃ๐˜ข๐˜ค๐˜ต๐˜ฆ๐˜ณ๐˜ช๐˜ถ๐˜ฎ and ๐˜ˆ๐˜ฌ๐˜ฌ๐˜ฆ๐˜ณ๐˜ฎ๐˜ข๐˜ฏ๐˜ด๐˜ช๐˜ข โ€“ along with lower rates of allergic disease. Rigor matters in emerging science. At Tiny Health, we ground our recommendations in evidence-based interventions supported by decades of microbiome research. Last fall, we published a randomized controlled trial showing these interventions can reduce the odds of developing atopic conditions by ๐Ÿด๐Ÿฏ%. (Study linked in the comments.) And what we hear from families isnโ€™t hype โ€“ itโ€™s relief. Relief as constipation improves, eczema clears, sleep deepens, and resilience builds. Small shifts that make a profound difference in daily life and long-term health. For families navigating persistent chronic health issues, those shifts arenโ€™t small. They can be life-changing especially when they happen early. Prevention can look unconventionalโ€ฆ right up until it becomes standard of care. And weโ€™re here to support families with science, data, and care every step of the way. Read the Wall Street Journal story here โ€“ wsj.com/health/wellness/pareโ€ฆ
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HMOs (human milk oligosaccharides) are a sugar found in human breast milk that babies mostly canโ€™t break down for energy. Yet HMOs are the third most abundant solid component in human milk (after lactose and fat). So, what are they doing there? HMOs feed the babyโ€™s future gut โ€œsecurity teamโ€ by passing through the upper gut and reaching the colon where they feed the important beneficial bacteria such as bifidobacteria. That means breast milk is actively shaping which microbes move in first โ€” and with them, the infant's gut and immune system. HMOs do more than just support good bacteria. They work like decoys... A lot of germs cause trouble by first sticking to receptors on the gut lining, the way a key fits into a lock. The bad actors grab onto the gut and "lock in" before they start their damage. HMOs can mimic those structures, so some pathogens bind to the HMO instead of your babyโ€™s actual cells. Itโ€™s like tossing a bunch of fake keys to distract the pickpocket. HMOs arenโ€™t one ingredient. Human milk can contain 200+ different HMO structures, and the blend changes over lactation and differs between moms because of genetics. Breast milk is an intelligent, dynamic, and personalized system that adapts as the baby grows. Once you โ€œgetโ€ HMOs, breastfeeding stops sounding like a "nice to have" and starts looking like a biological advantage during a vulnerable window. This is a critical period when babies are meeting the microbial world for the first time and their immune systems are in training mode. Formula can absolutely nourish babies, and itโ€™s essential and life-saving in a lot of real situations. Some formulas now add a small amount of HMOs. Thatโ€™s a meaningful step forward, but itโ€™s still not the same as the full, shifting HMO โ€œlibraryโ€ in human milk. Breast milk has been evolving alongside human infants for hundreds of thousands of years. HMOs are one small window into how sophisticated that system is and how much we're still learning. If breastfeeding is an option that's safe and doable for you, it's worth serious consideration.
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Big move by @PersephoneBio delivering a significant advancement to our understanding of the infant gut microbiome. Regardless of birth mode and/or early feeding method @StephJCuller and team found that: 76% of babies in their U.S. study were deficient in the key gut microbe: Bifidobacterium. 25% of their infants lacked detectable Bifidobacterium at all.
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Most parents wait until birth to start โ€œparenting.โ€ By then, itโ€™s already late.. Your baby's gut, brain, and immune system are all programmed BEFORE delivery day. If you want your child to thrive in the modern world, read this:
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Begin Health retweeted
dennis hegstad
@dennishegstad3 Aug 2023
what the hell ๐Ÿคฃ
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