@BeerenLab

Supramolecular chemistry group at the Technical University of Denmark

 Copenhagen, Denmark
kemi.dtu.dk/SophieBeeren
Joined September 2019
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  • Following52
  • Followers1.2K
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Large-scale synthesis of delta-cyclodextrin is possible using Enzyme-Mediated Dynamic Combinatorial Chemistry with superchaotropic templates. You can read about it in our latest article in JACS. pubs.acs.org/doi/full/10.102…

Enzyme-Mediated Dynamic Combinatorial Chemistry Enables Large-Scale Synthesis of δ‑Cyclodextrin

Abstract. α-, β-, and γ-cyclodextrins (CDs) are macrocycles formed from six, seven, and eight α-1,4-linked d-glucopyranose units and are industrially produ

pubs.acs.org
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Sophie Beeren retweeted
J. Am. Chem. Soc.@J_A_C_S10 Apr 2025
Enzyme-Mediated Dynamic Combinatorial Chemistry Enables Large-Scale Synthesis of δ-Cyclodextrin | Journal of the American Chemical Society @DTUtweet pubs.acs.org/doi/10.1021/jac…

Enzyme-Mediated Dynamic Combinatorial Chemistry Enables Large-Scale Synthesis of δ‑Cyclodextrin

Abstract. α-, β-, and γ-cyclodextrins (CDs) are macrocycles formed from six, seven, and eight α-1,4-linked d-glucopyranose units and are industrially produ

pubs.acs.org
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Sign up for the European Symposium on Organic Chemistry in Copenhagen. 'Early bird' registation ends on April 11th. esoc2025.com. Prominent speakers include our local 'click-chemistry' expert Professor Morten Meldal (researchprofiles.ku.dk/en/pe…...).
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Andy Extance@andyextance5 Apr 2024
Linking up individual sugar molecules is notoriously hard, which is why enzymes make cyclodextrins, used in skincare products and drugs. It has been impossible to make their mirror-image forms, until now... Story be me, thanks to @sirfrasersays @yongwu1990 @BeerenLab
Chemistry World@ChemistryWorld5 Apr 2024
Setting the stage for exploring the mirror-image world of naturally occurring cyclodextrins – rings of six to eight sugar units – scientists have synthesized the first L-cyclodextrins in the lab. chemistryworld.com/news/firs…

First mirror-image cyclodextrins come together ‘like Lego’

L-enantiomers could be more stable than their existing, more common, forms

chemistryworld.com
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In case you missed it: 'Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in complex mixtures' by Sophie Beeren and first author Dennis Larsen. @BeerenLab pubs.rsc.org/en/content/arti…

Quantitative determination of the binding capabilities of individual large-ring cyclodextrins in...

Large-ring cyclodextrins (CDs) are a comparatively unexplored family of macrocycles. We use high-resolution 1H–13C HSQC NMR experiments to resolve the anom

pubs.rsc.org
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Now online: News & Views on the Article by @YongWu1990 @sirfrasersays & co-authors at @NUChemistry @HKU_Chemistry nature.com/articles/s44160-0… ($) Synthesis of L-cyclodextrins by @BeerenLab nature.com/articles/s44160-0… ($)

Mirror-image cyclodextrins

Nature Synthesis - The making of mirror-image versions of naturally occurring cyclodextrins (CDs) is challenging and constitutes an untouched goal of the CD community. Now a concise approach is...

nature.com
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For those who are into the history of chemical compounds here is a summary of a few of synthesis-related milestones for cyclodextrins produced by @YongWu1990. @HKUniversity @NorthwesternU @NUChemistry @UTArlington
Yong Wu@YongWu199028 Mar 2024
The century old cyclodextrins finally got their mirror-images! Please check our latest Research Article in @NatureSynthesis. We hope the introduction of L-CDs, as we call them—in an efficient and scalable manner—might be useful for the community. @sirfrasersays @HKU_Chemistry
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Come and join my team! PhD and Postdoc positions available. We are looking for organic and supramolecular chemists to explore new ways of using enzymes for chemical synthesis of carbohydrates. efzu.fa.em2.oraclecloud.com/…
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See how we can make the large-ring cyclodextrin formed from 9-glucose units in JACS this week! Templated Enzymatic Synthesis of δ-Cyclodextrin pubs.acs.org/doi/10.1021/jac…

Templated Enzymatic Synthesis of δ‑Cyclodextrin

Abstract. While α-, β-, and γ-cyclodextrin (CD) are ubiquitous hosts employed by supramolecular chemists, δ-CD (formed from nine α-1,4-linked glucopyranose

pubs.acs.org
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Come and join my lab! I am looking for a PhD student and postdoc to work on my ERC project ENZYME-DCC. We are combining supramolecular chemistry with enzymology to synthesise oligosaccharides. efzu.fa.em2.oraclecloud.com/…
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I'm looking for two post-docs with expertise in supramolecular and synthetic organic chemistry to join our group working on enzyme-mediated dynamic combinatorial chemistry. You can read about the positions here: dtu.dk/english/about/job-and…
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Our collaboration with @aprahamian got a write-up in Chemistry World too!
Chemistry World@ChemistryWorld19 Jul 2021
A team of researchers in Denmark and the US have developed a light-controlled synthesis of the eight-glucose γ-cyclodextrin chemistryworld.com/news/mole…
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Our paper together with @aprahamian in @Chem_CP (bit.ly/3cZVRZ9) written about in a Dutch Newspaper! nrc.nl/nieuws/2021/06/30/lic…
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Put a ring on it! I spoke with @aprahamian and @BeerenLab about their work on a cheaper, light-powered gamma-cyclodextrin synthesis (in @cenmag): cen.acs.org/synthesis/Taking…

Taking the steam out of γ-cyclodextrin synthesis

Hydrazone template could make it cheaper to prepare this host molecule

cen.acs.org
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Just out in @Chem_CP! Photoswitch control of g-CD production!!! Great collaboration between @aprahamian and @BeerenLab, proud to have been part of it.
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My latest publication was mentioned in @cenmag! So cool. Great collaboration between @aprahamian and @BeerenLab. cen.acs.org/synthesis/Taking…

Taking the steam out of γ-cyclodextrin synthesis

Hydrazone template could make it cheaper to prepare this host molecule

cen.acs.org
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Two PhD Scholarships and one Post-Doctoral Position available in Supramolecular Chemistry from September 2020. @BeerenLab @ChemistryDtu @DTUtweet
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At pH 5 or pH 9? In 50 % ethanol or 7.5 M salt solution? Warm or cold? Bring it on! #CGTase is truly "the little enzyme that could" chemistry-europe.onlinelibra… #SysChem #SRBgroup #templatedirectedsynthesisofcyclodextrins @BeerenLab @DTUKemi
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Reaching for the sun - Dynamic combinatorial chemistry with carbohydrates #syschemposter
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Take a look at our latest cover art for 'Light-controlled out-of-equilibrium assembly of cyclodextrins in an enzyme-mediated dynamic system' by Sophie R. Beeren et al. @DTUtweet! Find the full paper here: ow.ly/rFfo50xE3si
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