@Becctococcus

Microbial population genomics | I am no longer active here. Find me at: @Becctococcus.bsky.social

 University of Oslo
linkedin.com/pub/rebecca-gladstone/25/523/31a
Joined September 2010
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Now published! 'Identification of transporter-dependent capsular loci associated with the invasive potential of Escherichia coli' nature.com/articles/s41564-0… insights below.....

Identification of transporter-dependent capsular loci associated with the invasive potential of...

Nature Microbiology - The development of an in silico typing database for Escherichia coli ABC transporter-dependent capsules enables analysis of capsule epidemiology and evolution for blood stream...

nature.com
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We created a database compatible with Kaptive3 of 90 distinct capsule (K) loci; 66% represented novel K-loci that did not correspond to the known phenotypic K-antigens. Give it a whirl, and get in touch to have novel K-loci added to the DB github.com/rgladstone/EC-K-t…

GitHub - rgladstone/EC-K-typing: E. coli K-antigen group 2 and group 3 typing database

E. coli K-antigen group 2 and group 3 typing database - rgladstone/EC-K-typing

github.com
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Data from invasive neonatal infections showed a major difference in the proportion of transporter-dependent K-loci between Europe and LMICs, indicating different vaccine design requirements.
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"Machine learning-based lineage prediction from antimicrobial susceptibility testing phenotypes for Escherichia coli sequence type 131 clade C surveillance across infection types" The MDR ST131-C is pervasive in UTIs, underlying BSI trends doi.org/10.1099/mgen... @MicrobioSoc
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It's largely infeasible for national genomic surveillance at the scale AST data is available (here 24,866 BSI and 28,639 UTI E. coli, 2006–2021), but combining existing 3254 BSI genomes and AST data allowed us to estimate the importance of a notorious MDR clone in Norwegian UTIs.
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And special thanks to Handal and Kaspersen et al. (doi.org/10.1093/jac/...) for sharing their AST data to serve as a UTI validation set.
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How invasive are different E .coli capsules and how many are there? Find out here and use the group 2 and 3 database to type your own! medrxiv.org/cgi/content/shor…
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Dr. Rebecca Gladstone retweeted
GlobalPneumoSeq@pneumowatch1 Nov 2024
Unsung hero who processed tens and thousands DNA 🧬 extraction for the #GPS_project @sangerinstitute Left to Right: Sally Kay, Kirsty Ambridge, Terry Judah, Annie Fletcher, Nicole Sevilleno, James Groom and Divenita Govender #pneumococci #DNA #Genome
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What's cool about this is the fact that Norway has been sequencing all IPD routinely since 2018! Coupled with >20 years of pre-PCV data we can really see the fantastic impact of vaccination, and the role of those pesky NVTs aready in Norway just waiting in the sidelines
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Dr. Rebecca Gladstone retweeted
Michael Baym@baym20 Jun 2024
So seriously, in grad school a therapist gave me some solid advice: If you try to bring work on vacation you’ll succeed at neither. You have to give yourself permission to relax knowing the work will still be there for you when you return
Vikas Navratna@vikasnavaratna20 Jun 2024
How do you enjoy a vacation without feeling guilty or anxious?
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Dr. Rebecca Gladstone retweeted
Sophie Belman@BelmanSophie13 Jun 2024
I’m excited to share our work Estimating between-country migration in pneumococcal populations academic.oup.com/g3journal/a… out now in G3 @GeneticsGSA 1/9

Estimating between-country migration in pneumococcal populations

Abstract. Streptococcus pneumoniae (the pneumococcus) is a globally distributed, human obligate opportunistic bacterial pathogen which, although often carr

academic.oup.com
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Dr. Rebecca Gladstone retweeted
GlobalPneumoSeq@pneumowatch6 Jun 2024
✨New Opportunity! ✨ Calling all GPS partners - we're recruiting an early career postdoc for a placement here in Cambridge! Find out more and apply here by the 31st of July! ⬇️ forms.gle/UcT1WTZwCR54vj3x8
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💥 "GET OFF THE ROAD, BITCH!" 9/10 women cycling in London face abuse says new LCC survey. CW: swearing, abuse descriptions Sign the #FreedomToRide petition & share to add your voice >> action.lcc.org.uk/safe-cycli… Full report: lcc.org.uk/freedom
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Dr. Rebecca Gladstone retweeted
Dr Elita Jauneikaite@ElitaJaun10 Jan 2024
Come and work with us on a range of very excited and important projects! We are using genomics to better understand clinical infections and AMR!
HPRU AMR@HPRUamr10 Jan 2024
Great opportunity for a talented Researcher to come and work with us in the lab 🧫🔬! Deadline to apply is 23 Jan. jobs.ac.uk/job/DFF852/resear…
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It's out! Further exploring different ST131 clade success in UK/Norway due to abx use! Modulation of multidrug-resistant clone success in E. coli populations: a longitudinal, multi-country, genomic and antibiotic usage cohort study - The Lancet Microbe thelancet.com/journals/lanmi…

Modulation of multidrug-resistant clone success in Escherichia coli populations: a longitudinal,...

Our study indicates that resistance profiles of contemporaneously successful clones can vary substantially, warranting caution in the interpretation of correlations between aggregate measures of...

thelancet.com
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We also used E.coli colonisation frequencies in a UK neonatal cohort to compare success in disease against colonisation. We confirmed C1 and C2 are found considerably more often than expected in disease. Clades A and B are found more often in carriage.
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Teamwork makes the dream work! AK Pöntinen*, RA Gladstone*, @henri_pesonen , M Pesonen, F Cléon, BJ Parcell, T Kallonen, GS Simonsen, NJ Croucher, @alanmcn1 @JulianParkhill @Paal_Johnsen @Orjan_Samuelsen & J Corander!
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