🔬 Postdoc @labyoule @NIH @NINDS | Former @WellcomeTrust PhD @LivUni | 🧠 Researching #Neurodegeneration, #Autophagy, #Drosophila | 📢 Views my own
Washington, D.C. US
Joined July 2011
- Tweets190
- Following743
- Followers242
- Likes1.1K
Pinned Tweet
I'm thrilled to announce that my 2nd first-author paper has been published in @LSAjournal. Huge thanks to my co-authors and the reviewers for their invaluable contributions. #NIX #USP30 #NBR1 #Pexophagy #peroxisome @LivUniISMIB @CCI_liv @wellcometrust
life-science-alliance.org/co…
Francesco G. Barone, PhD retweeted
Happy to see our paper, led by outstanding postdoc Alessandra Esposito, out in @Nature today. We uncovered a TBK1/ULK1 signaling pathway that acts as a lysosome quality control mechanism, regulating the FLCN-TFEB axis in response to lysosomal stress
Link: rdcu.be/icEViqq6F68a
Francesco G. Barone, PhD retweeted
An excitable #Rho #GTPase signaling network generates dynamic subcellular contraction patterns, by Melanie Graessl, Johannes Koch, Leif Dehmelt, Perihan Nalbant et al. hubs.la/Q04p9Gbd0
📕 In “Collective Behaviors and Self-Organization in Cells”: hubs.la/Q04p9_s20
Francesco G. Barone, PhD retweeted
New study from our lab at NICHD, NIH! We identify TBC1D9 and TBC1D9B as novel ARL8 effectors that suppress #exosome secretion by inactivating RAB11A and thus blocking exocyst-dependent fusion of multivesicular endosomes with the plasma membrane. pnas.org/doi/10.1073/pnas.25…
Francesco G. Barone, PhD retweeted
Yue Xiong, Weihua Gao, Zelai Wu, Xiukui Gao, Qiming Sun et al. (@ZJU_China) present new mouse models for visualizing the selective degradation of #peroxisomes (#pexophagy) in living animals. hubs.la/Q03ZxzpT0
Francesco G. Barone, PhD retweeted
Many thanks to Amelia Glazier and The Journal of Cell Science for including me in ‘First Persons’ through the decades – 100 years of notable scientists in The Journal of Cell Science journals.biologists.com/jcs/… Happy to be in such great company!
Francesco G. Barone, PhD retweeted
Precise, predictable genome integrations by deep-learning-assisted design of microhomology-based templates go.nature.com/41GoBiX
Francesco G. Barone, PhD retweeted
Excited to share our new review with @DePaceRaffa, @SaikatSls, @cd_w1 @NIH on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases #lysosomes #melanosomes #synapses #kinesins authors.elsevier.com/a/1lg4i…
Francesco G. Barone, PhD retweeted
Inflammatory and anti-inflammatory cytokines bidirectionally modulate amygdala circuits regulating anxiety: @CellCellPress cell.com/cell/fulltext/S0092…
Diverse routes to mitophagy governed by ubiquitylation and mitochondri... sciencedirect.com/science/ar…
Francesco G. Barone, PhD retweeted
It was a pleasure to collaborate with @BaroneFraG ! Great work, involving #lightsheet microscopy.
@EuroBioImaging @LivUniCancer @livuniLivSRF
1/8
🚨 New publication alert! 🚨
We developed live #Drosophila melanogaster models with fluorescent reporters to study #pexophagy – the selective autophagy of peroxisomes – in vivo. 🧵👇 @livuninews @wellcometrust @CCI_liv @LivUniHLS
Francesco G. Barone, PhD retweeted
Visualize global & tissue-specific #Pexophagy in #Drosophila 🤠
Pexo-QC
Pexo-Keima
SKL signal for translocation to #Peroxisome matrix
@BaroneFraG @Natsansor #OpenBiology 2025
royalsocietypublishing.org/d…
Read the excellent🧵from 1st auth @BaroneFraG 👇
xitter.cf/BaroneFraG/status/1887…
1/8
🚨 New publication alert! 🚨
We developed live #Drosophila melanogaster models with fluorescent reporters to study #pexophagy – the selective autophagy of peroxisomes – in vivo. 🧵👇 @livuninews @wellcometrust @CCI_liv @LivUniHLS
Francesco G. Barone, PhD retweeted
Interested in pexophagy? Check out our newly published work: we developed pexophagy reporters for use in Drosophila research. Very happy to have been involved in this collaboration @LivUniISMIB
royalsocietypublishing.org/d…
1/8
🚨 New publication alert! 🚨
We developed live #Drosophila melanogaster models with fluorescent reporters to study #pexophagy – the selective autophagy of peroxisomes – in vivo. 🧵👇 @livuninews @wellcometrust @CCI_liv @LivUniHLS
1/8
🚨 New publication alert! 🚨
We developed live #Drosophila melanogaster models with fluorescent reporters to study #pexophagy – the selective autophagy of peroxisomes – in vivo. 🧵👇 @livuninews @wellcometrust @CCI_liv @LivUniHLS
7/8
Applications:
These tools enable precise genetic and chemical manipulation of pexophagy, paving the way for studying disease mechanisms (e.g., neurodegeneration) and cross-talk between organelles like mitochondria and peroxisomes.
8/8
Explore our findings! 📄
Read the full paper here: royalsocietypublishing.org/d…
Published in @RSocPublishing #OpenBiology
Big thanks to my collaborators and mentors for their incredible support. Questions or feedback? Let’s discuss! #ScienceTwitter #Autophagy #Pexophagy @LivUni