Chris Simms retweeted
Don’t miss #EACVI webinar on how to use #multimodality #imaging during pregnancy and peripartum under @escardio @EACVIPresident with @leylaelifsade @anagalmeida1
Register today : esc365.escardio.org/event/27…
@escardio
@MGBWomenHeart
@MassGenBrigham
🤖 Made with AI
Chris Simms retweeted
Hansoh Pharma CBO Weiyong Sun describes strategy behind Roche co-development deal in interview with BioCentury buff.ly/pGQmGYJ
Chris Simms retweeted
Please join us October 21 & 28th from 7-9 pm EST for our 9th annual virtual #SOUTHASIAN Cardiovascular Conference. Beautiful Canadian 🇨🇦🇺🇸 USA collaboration!
Register for Free & Join the discussion live!:
🔗 ccrnmd.com/south-asian-cardi…
#Southasiancardiovascularhealth
Chris Simms retweeted
Thoughtful insights from one of my first EP Mentors @DrJGoldberger. Refreshing and unconventional Table 1 on the state of modern healthcare “alignment”.
Cardiac Electrophysiology at a Crossroads: Building on Dr. Josephson's 20 years of observations. Is EP science, procedure or both? What is the future of EP science?
authors.elsevier.com/a/1nzSl…
#EPeeps #CardioX @ACCinTouch @HRSonline
Chris Simms retweeted
prediction/spectral observation of drug induced liver injury - tamoxifen (left) versus control/DMSO (right)
liver tox alone accounts for roughly 1 in every 4.5 drug failures in human clinical trials, AND then 1 out of 3 market withdrawals of approved drugs.
we see it.
Chris Simms retweeted
#echofirst question
How often is PISA EROA in primary eccentric MR suitable?
How often should we use PISA / EROA for severity quantification?
@argulian @echo_batman @Ph_Bertrand @dr_benoy_n_shah
Chris Simms retweeted
The future of cardiovascular CT starts in Dublin! Join colleagues from around the world for SCCT Global 2027, January 28–29, featuring the latest advances in imaging, technology and clinical practice.
Register: scct.org/page/SCCTGlobal2027
Chris Simms retweeted
One number per drug. It fits in a spreadsheet, so public databases hold millions of them.
In 2024 two researchers at ETH Zurich went through the main public database and found the cases where the same drug had been measured against the same protein in two different experiments. In about 65% of pairs the two IC50s disagreed by more than 2x. In 27% they disagreed by more than 10x. After matching the experiments as closely as the records allow, it was still 48% and 13%.
In 2013 the two biggest cancer drug screens of their time were compared, one from the Broad Institute and Novartis, one from the Sanger Institute. They shared 15 drugs and 471 cell lines. The gene readouts agreed. The drug response numbers did not. The authors' words: "highly discordant."
In 2016 a Harvard group showed one reason. An IC50 depends on how many times the cells divide during the test. Two cell lines can get different numbers only because one divides faster. Run the same test for longer and the number moves.
Two weeks ago a group went back to the original papers behind 74,425 binding measurements, recovered how each one was done, and gave that to the model along with the number. Predictions got a little better. The label was missing its context all along.
Noise is the smaller problem. An IC50 is read at the end. Cells that die in six hours one way and cells that die in sixty hours another way can land on the same number.
At Precigenetics we don't take one number at the end. We record the same living cells from before the drug goes in until the response is over, reading their chemistry with laser light, no dyes. In our data a cell's commitment to die shows up in its chemistry hours before a standard viability test registers anything.
Chris Simms retweeted
Echo From Scratch | Post #44
TEE From Scratch: The Standard Examination Sequence
TEE is more than inserting a probe and obtaining images. A systematic examination helps assess all four chambers, the cardiac valves, the aorta and adjacent structures.
1. Understand the probe positions
The standard examination uses several positions:
- Upper esophageal
- Midesophageal
- Transgastric
- Deep transgastric
2. Master the key midesophageal views
Multiplane angle refers to the rotation of the imaging plane, not the direction of probe advancement.
- 0°: Four-chamber view. Assess both atria, both ventricles and the AV valves.
- Around 60°: Mitral commissural view. Evaluate mitral leaflet anatomy and commissures.
- Around 90°: Two-chamber view. Focus on the LV and LA.
- Around 120°: Long-axis view. Visualize the LV, LVOT, aortic valve and mitral valve.
These angles are approximate starting points. Small adjustments are often needed to obtain the optimal view.
3. Assess the aortic valve and right heart
As the probe is withdrawn, additional views help evaluate:
- Aortic valve in short axis and long axis
- Aortic root and ascending aorta
- RV inflow and outflow
- Tricuspid valve and pulmonary valve
4. Advance into the stomach
Transgastric imaging provides additional ventricular views:
- Basal LV short axis
- Mid-LV short axis
- Two-chamber view
- LV long-axis view
- RV inflow view
These are particularly useful for assessing ventricular function, regional wall motion and selected Doppler measurements.
5. Finish with the aorta
A systematic examination also includes imaging the descending thoracic aorta and, when indicated, the aortic arch.
Key takeaway: A standard TEE examination follows a structured sequence, but the final views must be tailored to the clinical question. No single view provides a complete assessment of cardiac anatomy or function.
Chris Simms retweeted
IL-12–producing iPSC-derived antigen-presenting cells enhance antitumor immunity and enable off-the-shelf immunotherapy dlvr.it/TVxqCh #genetherapy #celltherapy
Chris Simms retweeted
🔎 FDA News: The #FDA has granted a second fast track designation to invikafusp alfa for unresectable, locally advanced or metastatic TMB-H solid tumors that have progressed following prior treatment.
Read more: targetedonc.com/view/invikaf…
#Oncology #CancerTreatment
Chris Simms retweeted
Permitting medical device manufacturers to submit bulk summary reports of adverse events to the US Food and Drug Administration, rather than reporting individual cases, often fails to promptly detect potential safety signals, finds new #BMJResearch
bmj.com/content/395/bmj-2026…
Chris Simms retweeted
In BioCentury's Management Tracks: Former Galapagos executives Paul Stoffels and Willemijn Kremer have landed at Armed Cell Therapies and taken rights to CAR T programs that had belonged to their former employer; and more buff.ly/GZalJxz
Chris Simms retweeted
Looking forward to this. #AHA2026
Most clinicians & scientists don’t set out to start a company. They set out to solve a problem. At #ScientificSession26, our first-ever Innovation Forum with @AHAScience opens with The Entrepreneur’s Journey: a candid talk on getting from idea to impact. professional.heart.org/en/me…
Chris Simms retweeted
Among patients with metastatic #BreastCancer, alert-based digital patient-reported outcome monitoring was associated with lower fatigue at 6 months vs usual care, with improvement exceeding the minimal clinically important difference.
ja.ma/4hRo6Ly
Chris Simms retweeted
Launch of WHO global report
“State of inequality: noncommunicable diseases and their risk factors”
October 22, 2026
who.int/news-room/events/det…
Chris Simms retweeted
Coming to YT on Sunday, tune in!
Or, watch it now, ad-free (74 minutes): patreon.com/MichaelLustgarte…
Chris Simms retweeted
☕ Norwegian study: Coffee drinkers had fewer repeat blood clots after a first event. 1-2 cups daily linked to the lowest risk - especially after provoked clots. news-medical.net/news/202610… #Coffee #BloodClots
Chris Simms retweeted
In this live case, Abdul Parwani demonstrates his approach to transseptal puncture during balloon-in-basket PVI.
Rather than introducing an additional sheath for transseptal access, the team performs the puncture directly through the Agilis sheath, a technique Abdul describes as feasible within their workflow.
Using biplane angiography, the team visualises the anatomy in right and left oblique views before performing the transseptal puncture and using contrast to confirm entry into the left atrium.
The case provides practical insight into a streamlined approach to left atrial access before progressing to balloon-in-basket PVI.
#RIOCongress #EPeeps #PVI #AFib #Electrophysiology
Chris Simms retweeted
Will it do the 250 clicks required to close a clinic encounter?
Meet Abridge Assistant, the AI assistant for healthcare.
abridge.com/blog/abridge-ass…




































