A federally-funded RNA Manufacture and Research Hub located at @AIBNatUQ | Tweets about the all latest mRNA news | Retweets are not endorsements.
Brisbane, Australia
Joined June 2021
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BASE mRNA Facility retweeted
🎧 Listen to episode 4 of VAXXED to hear AIBN's @SethCheetham talk about the scalability of mRNA for clinical use.
As well as leading research at AIBN Seth is the director of the @BASEmRNA - the biggest supplier of mRNA in Australia.
Listen buff.ly/3OfWnV9
BASE mRNA Facility retweeted
Massive thanks to Professor Wilson and co for dropping by to see what we we’ve been up to at:
💡 The @anffq with Zaw Htoo (Ethan) Aung
🧬 The @BASEmRNA with @SethCheetham
BASE mRNA Facility retweeted
The greatest challenge for #mRNA-LNP therapies is targeting non-liver tissues. To overcome this, we used customisable bispecific antibodies to tether mRNA-LNPs to cell-surface proteins, achieving efficient and selective mRNA delivery in vivo. @BASEmRNA
biorxiv.org/content/10.1101/…
BASE mRNA Facility retweeted
We're hiring a senior research assistant to help drive our research ambitious programme in mRNA drug discovery including individualised cancer vaccines. The position join a high-performing team at the @AIBNatUQ @BASEmRNA Please share! Apply 👇
uq.wd3.myworkdayjobs.com/uqc…
BASE mRNA Facility retweeted
🧬Personalised mRNA cancer vaccines are now being used to train the body’s immune system to recognise & eradicate cancer cells.
Despite the potential Aust researchers haven’t had the infrastructure to build these vaccines, leading to a gap in the local drug development pipeline.
BASE mRNA Facility retweeted
You've heard of mRNA from it's use in vaccines, but what actually is it? Could it be used to treat other illnesses?
Watch @SethCheetham, from @BASEmRNA explain how mRNA therapeutics can be tailored to a single individual: making a drug as unique as a fingerprint ☝
BASE mRNA Facility retweeted
Last chance to apply for this three-year postdoctoral position and lead research in one of the most exciting areas of cancer therapeutics!
We are hiring for a research fellow to lead research at the new MRFF-funded Australian Centre for Cancer Vaccines. The position will join a passionate team of scientists at one of Australia's leading #mRNA hubs at @AIBNatUQ @BASEmRNA Apply below 👇
uq.wd3.myworkdayjobs.com/uqc…
BASE mRNA Facility retweeted
We are hiring for a research fellow to lead research at the new MRFF-funded Australian Centre for Cancer Vaccines. The position will join a passionate team of scientists at one of Australia's leading #mRNA hubs at @AIBNatUQ @BASEmRNA Apply below 👇
uq.wd3.myworkdayjobs.com/uqc…
BASE mRNA Facility retweeted
AIBN's Dr @SethCheetham will be speaking at @TEDxUQ 2024
Dr Cheetham has been pivotal in establishing the @BASEmRNA Facility, Australia’s leading provider of mRNA for research and pilot studies. His research focuses on using mRNA to develop new therapeutics and vaccines. 💉
BASE mRNA Facility retweeted
TRI was honoured to host His Excellency Dr Fahad Altaffag, Ambassador of UAE, with experts in research, infrastructure, investment and international partnerships. #UAEEmbassy @Brisbane_EDA @brisbanecityqld @tradeinvestqld @thermofisher @BASEmRNA @UQ_News @qldscience @AdvanceQld
BASE mRNA Facility retweeted
🧬🔬 More than half the time and cost to manufacture an mRNA vaccine is dedicated quality control - which is currently slow, expensive, and inaccurate.
@Mercerlab and the team at @BASEmRNA are working to change that 🧵
BASE mRNA Facility retweeted
Double congrats👏AIBN Group Leader/@BASEmRNA Dep Director Dr Cheetham + PhD student Aria Zhu received grants to further #cancerresearch from @tourdecure_aus
Seth: Targeting liver cancer w. mRNA therapies
Aria: Nanomedicine for siRNA delivery of gene therapies on medulloblastoma
BASE mRNA Facility retweeted
An mRNA can encode the same protein sequence more ways than there are atoms in the known universe (10^632 for COVID19 spike), but which one is the best? @moderna_tx CSO Melissa Moore reviews the state of the art of #mRNA design in @NatRevDrugDisc
nature.com/articles/s41573-0…
BASE mRNA Facility retweeted
As demand for #mRNA vaccines and therapies surge, so too do our capabilities in this highly innovative field. Excited to see mRNA's strong future here at #UQ's AIBN thanks to @BASEmRNA, who received $4.3m from the @healthgovau #MRFF and contributions from #UQ @sanofi @QldGov👏
A dedicated lab will produce mRNA for clinical trials @AIBNatUQ's BASE facility.
The next generation of mRNA vaccines and therapies will be built in Queensland, thanks to $4.3m from @healthgovau, #MRFF and contributions from #UQ @sanofi @QldGov👏
More: uq.au/BASE
ALT UQ's Dr Seth Cheetham with Dr Iris Depaz from Sanofi, Deputy Premier Steven Miles and Associate Professor, Tim Mercer.
BASE mRNA Facility retweeted
The discoveries by Katalin Karikó and Drew Weissman – awarded the 2023 #NobelPrize in Physiology or Medicine – were critical for developing effective mRNA vaccines against COVID-19 during the pandemic that began in early 2020.
Through their groundbreaking findings, this year’s laureates have fundamentally changed our understanding of how mRNA interacts with our immune system. They have contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times.
ALT A blue background with COVID-19 virus and a yellow strand of modified mRNA. Also shown is the chemical structure of pseudouridine, an RNA base that was important in the prize-awarded discovery. The graphic represents the 2023 Nobel Prize in Physiology or Medicine awarded to Katalin Karinkó and Drew Weissman who received the Nobel Prize in Physiology or Medicine for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
BASE mRNA Facility retweeted
Simultaneous delivery of a CAR #mRNA and PD-1 knockdown for mRNA-enhanced CAR-T therapies. Out now in Advanced Healthcare Materials
@AdvSciNews from @MJMitchell_Lab @a_hmltn
onlinelibrary.wiley.com/doi/……
BASE mRNA Facility retweeted
Wild @Nature paper finds that a phage enzyme can covalently link RNAs to proteins. The enzyme uses the NAD-cap of the phage mRNA as a substrate for the RNAlytation (or proteinylation) reaction. From
@HoeferLab @JaeschkeLab @MaikSchauerte
nature.com/articles/s41586-0…
BASE mRNA Facility retweeted
Cytidine acetylation generates hypo-immune synthetic #mRNAs by reducing interactions with cytidine-binding proteins/immune sensors. From @DrKnance and @doc_jlmeier in @CellChemBiol
cell.com/cell-chemical-biolo…
BASE mRNA Facility retweeted
While #mRNA vaccines for viruses have been getting all the attention, bacterial vaccines are rapidly progressing. This Lyme disease vaccine shows strong preclinical efficacy compared to recombinant protein. From @pardi_lab in @MolTherapy
sciencedirect.com/science/ar…
BASE mRNA Facility retweeted
Can #mRNA therapies turn immunologically cold tumours hot? Xiaoyang Xu and team found an mRNA-encoded fragment of Gasdermin delivered by LNPs induces robust anti-tumour immunity and sensitises tumours to checkpoint inhibition. @NatureComms
🥶 --> 🥵
nature.com/articles/s41467-0…