PhD student at WTKLAB @UnivCampharm / @SCICambridge with @cambridge_uni

Joined February 2019
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We are forming a patient advisory group to help shape our research on BRCA breast cancer prevention! Follow the link/scan the barcode for more info and to express interest. Please RT! @WTKLAB stemcells.cam.ac.uk/about-us…
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📢Paper alert: We used #3Dpathology and CNVseq to understand the evolution of #precancer in the #humanbreast 🔬🧬Pre-malignant breast transformations develop within mutant clonal fields of morphologically normal-looking ducts 📰:tinyurl.com/2cka7wwc 🏥: @vib_ccb @NKI_nl
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Read Cancer Discovery's #ResearchWatch: A Single-Cell Atlas Uncovers Cellular Dynamics of the Human Breast, summarizing the work of @AustinDReed, @Dr_SaraPensa, @MarioniLab, @WTKLAB et al. bit.ly/4dqgLyt @univcampharm @SCICambridge
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A paper in @NatureGenet reports on a single-cell RNA sequencing analysis of over 800,000 human adult breast cells, which identifies 41 cell subtypes and highlights age- and parity-dependent effects. go.nature.com/49r4ir1
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Austin Reed retweeted
Here is a research briefing @NatureGenet explaining our the story behind the Atlas. rdcu.be/dDn9L
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Its finally here! I am excited to announce our paper on the Human Breast Cell Atlas is live now at @NatureGenet! A massive thank you to everyone involved particularly my amazing co-author @Dr_SaraPensa, project leads @WTKLAB and @MarioniLab and the @BreastCancerNow tissue bank!
I am pleased to share the final version of our Human Breast Cell Atlas with @MarioniLab now out @NatureGenet. There are important new additions, which I will leave to @Dr_SaraPensa and @AustinDReed to mention👇 . Couple of points i want to highlight 👇: nature.com/articles/s41588-0…
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One of our key findings from the HBCA was that women carrying BRCA1 and BRCA2 mutations have a significantly increased presence of immune cells in the breast.
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Our HBCA captures the cellular heterogeneity of the resting breast and characterises the many changes imparted by age, parity and germline BRCA1/2 mutations at a cellular level. Have a look at our previous thread on the bioRxiv for more details!
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Super excited to be sharing the preprint for my first paper alongside co-author @Dr_SaraPensa with help from many others across @WTKLAB and @MarioniLab! A massive thank you to everyone who made it all possible!
I am very pleased to share our second and largest contribution to “The Human Breast Cell Atlas” (HBCA) project. Buckle up a longish thread ahead! biorxiv.org/content/10.1101/…
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Not sure yet on release date, but we have patients from a wide range of differing age, parity and menopause status included!
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Thank you! They are ‘normal’ mammary epithelial cells for all patients
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