Assistant Professor @UCLA | Interested in using synthetic biology to better understand development and control cell fate | Views and opinions change over time
Los Angeles, CA
Joined October 2015
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Amjad Askary retweeted
1/14
On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.1101/…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse model of lung metastasis, we dissect how cell-intrinsic and environmental factors coordinately shape tumor evolution in vivo.
Amjad Askary retweeted
Kai Hoa from Amjad Askary's lab @AskaryLab on recording signaling histories in single cells via INSCRIBE
Check out their bioRxiv:
biorxiv.org/content/10.1101/…
#SysBioSC2025
Amjad Askary retweeted
Spatial proteomics is here, but spatial functional proteomics?
Here is our Nature BME paper on spatial protein interactomics (nature.com/articles/s41551-0…) illuminating how 47 proteins co-localize/ interact within 20 nm and their function in tissues.
@naturemethods @rita_strack
The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳
For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread.
nature.com/articles/s41592-0…
Amjad Askary retweeted
So we beat on. Gene/cell therapies often use proteins that could be recognized/rejected as non-self by our immune system. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025.02.24.6…
Amjad Askary retweeted
Nice article in Scientific American about our work on outer ear evolution and a complimentary study from the lab of Maksim Plikus on role of unique lipids in mammalian ear cartilage. @MathiThiru95 @USCStemCell @KECKSchool_USC
scientificamerican.com/artic…
Amjad Askary retweeted
How does one (signaling) arm know what the other is doing in the cell? Through a network of bHLH transcription factors obviously! Our work showing how neural stem cells integrate signals to coordinate a fate response is now out: cell.com/cell-reports/fullte…
Amjad Askary retweeted
It's published! rdcu.be/d6kVt
When we talk about viral protease-based circuits, people wonder: "if it's meant as therapeutics, are you concerned about immunogenicity"? Now, in hDIRECT, we established control of cytokines using a human protease and its FDA-approved inhibitor: doi.org/10.1101/2024.01.18.5…
Amjad Askary retweeted
A month ago we @vevo_ai announced that we have generated the largest single-cell perturbation atlas in history, Tahoe-100M. Today, we announce that we will fully open-source Tahoe-100M in Feb, as part of a collaboration with @NVIDIAHealth to train cell state models.
Amjad Askary retweeted
A dream come true: in 2004 I started thinking about counting microstates to predict gene expression with @JKondev Rob Phillips @HernanGGarcia. 20 years later we can measure them: nature.com/articles/s41586-0… Thank you @WJGreenleaf @bgrdoughty @MichaelaThinks Julia and all co-authors!
Amjad Askary retweeted
New Publication Alert!
our perspective of "Aging on a chip" and "Spatial Omics" in aging single cells.
Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omics
npj Aging10, 57 (2024)
Link: lnkd.in/ef7-ad7Q
@CoulterBME
Amjad Askary retweeted
Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s41586-0…
Amjad Askary retweeted
Our work describing molecular recording of sequential information by directing a chain of insertions with prime editor in mammalian cells is now published in @nchembio here - nature.com/articles/s41589-0…. Congratulations to Theresa Loveless, @CourtneyCarls_n, and the whole team!
Amjad Askary retweeted
Check out this amazing resource! High quality illustrations for free!
bioart.niaid.nih.gov/
HT @LuciaScience
Amjad Askary retweeted
We are excited to introduce LoRNA-SH, a frontier RNA foundation model that leverages long-read transcriptomics and long-context inputs to learn and predict the transcriptome architecture with base-pair resolution: biorxiv.org/content/10.1101/…
Amjad Askary retweeted
Today out in @biorxivpreprint we present SCOPE. An optics-free, self-registering array of DNA encoded beads for spatial genomics. This was work led by the intrepid duo of Hanna Liao and Sanjay Kottapalli, with @JShendure's lab. biorxiv.org/content/10.1101/…
Amjad Askary retweeted
Thrilled to introduce IRISeq, a scalable, cost-effective and imaging-free spatial genomic technique for mapping mammalian brain aging, developed by incredible Abdul @Abdul_Squared and Weirong from our lab at @RockefellerUniv!
biorxiv.org/content/10.1101/…
Amjad Askary retweeted
Levels of gene expression matter! So how can you control a transgene precisely? Is there a tool that can ensure uniform control & the ability to adjust the setpoint of expression from a single promoter? Introducing DIAL! 🧵 (1/n)
Link: doi.org/10.1101/2024.06.19.5…
Amjad Askary retweeted
Our first RNA-centric preprint is online! Congratulations to @abbythurm and the whole team - we're so excited to continue learning about effector domains in RBPs, and to hear your thoughts about what could come next!
Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint @BintuLab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.1101/… (1/9)
Amjad Askary retweeted
Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously.
nature.com/articles/s41586-0…
Amjad Askary retweeted
Do you really need to spread plasmid libraries on mountains of plates to get uniform growth, or can you just dump them in a flask and call it a day? We make huge plasmid libraries in the de Boer Lab, so we tested whether culture method really matters. 1/ biorxiv.org/content/10.1101/…