'Innate'-ly Scientist • Instructor in Pediatrics @HarvardMed • Postdoc @Lo_Zanzi @BostonChildrens • Ph.D. @FitzgeraldKate @UMassChan
Boston, MA
Joined May 2018
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Sreya Ghosh retweeted
What comes after M1/M2? In our Perspective with @FGinhoux in @ImmunityCP we explore how single-cell technologies and AI can decode the gene programs macrophages use across tissues & microenvironments, and how this modular view could transform immunotherapy
cell.com/immunity/abstract/S…
Sreya Ghosh retweeted
#LocationLocationLocation! Excited for a small contribution to the new work @MolecularCell by Flynn, Porat &co showing that mitochondrial DNA is exposed on the plasma membrane & can be removed by DNASE1L3, aberrantly accumulating in #lupus patients! doi.org/10.1016/j.molcel.202…
Sreya Ghosh retweeted
BREAKING NEWS
The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
Sreya Ghosh retweeted
Last days to register for the #IFN-λ satellite workshop on Oct 22nd, right after the @CytokineSociety meeting in #Glasgow. Deadline extended to Oct 7th. Remember, registration is #free but MANDATORY! ifnlworkshop.org
Sreya Ghosh retweeted
ai3Bio Launches with $48 Million in Series A Funding to Reset the Immune System at Its Root - businesswire.com/news/home/2…
Sreya Ghosh retweeted
SURPRISE! Key interferon-stimulated genes (ISGs) can be induced without interferon! Sounds like an oxymoron, but it is true! Read the paper to find out more.
Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation: Cell cell.com/cell/fulltext/S0092…
Sreya Ghosh retweeted
Thrilled to share our latest work, out in @SciImmunology! We show that tissues match their #macrophage numbers to #mitochondrial_activity , ensuring efficient #waste_clearance and #tissue_fitness . A tour de force by Laura Pena-Couso, in collab with @andrsHidalgo16 & Pura Muñoz🧵
Sreya Ghosh retweeted
#WeekendRead! #SharingIsCaring! Pena-Caruso Munoz @andresHidalgo16 @NicolasAvilaJA &co show @SciImmunology that macrophages support muscle activity by clearing mitochondria from myofibroblasts that tune macrophage no. controlling CSF1/fibroblast abundance!
science.org/doi/10.1126/scii…
Sreya Ghosh retweeted
Another major milestone for my lab - our second paper is out today in Nature Biotechnology! Co-led by @pascal_devant & @HyuncheolJung, with Alex Marson: nature.com/articles/s41587-0…
Sreya Ghosh retweeted
The final version of my first postdoc paper is out today in @NatureBiotech! nature.com/articles/s41587-0…
Together with @HyuncheolJung @jccarnevale we established a virus-like particle toolkit for genetic engineering and pooled CRISPR screening in primary human myeloid cells 🧬
Sreya Ghosh retweeted
Beyond antibodies: Emerging roles of B cells in gastrointestinal inflammation and disease: mucosalimmunology.org/articl…
Sreya Ghosh retweeted
New paper 🚨 We built a mouse model (CD101-tdTomato) to finally track mature neutrophils. Sharing both the findings and the tool — hope labs working on neutrophil biology find it useful👇
Genetic tool for specific tracking of mature neutrophils
Read more on hLife👇👇👇
doi.org/10.1016/j.hlife.2026…
Sreya Ghosh retweeted
Pleased to share our review "Metabolic danger signals: TCA cycle metabolites regulate immunity and disease" @CellChemBiol.
@Lo_Zanzi and I discuss how TCA cycle metabolites act as metabolic DAMPs to shape infection, inflammation, autoimmunity, and cancer. authors.elsevier.com/c/1nYgP…
#ImmunometabolismPower! Excited to share our review @CellChemBiol with super-talented @tristramryan about the activity of immunometabolites of the #TCA #Krebs cycle working as metabolic damage-associated molecular patterns #metaDAMPs in health & disease! authors.elsevier.com/a/1nYgP…
Sreya Ghosh retweeted
Excited this multi-year collaboration is in print @NatureGenet with @mikhailspivakov @MalyValerie @HelenR_J
Low-input Capture Hi-C reveals promoter-anchored chromosomal interactions in human ILC3 prioritzing CLN3 & other genes as ILC3-specific mediators of genetic risk for #IBD
Sreya Ghosh retweeted
#ImmunometabolismPower! Excited to share our review @CellChemBiol with super-talented @tristramryan about the activity of immunometabolites of the #TCA #Krebs cycle working as metabolic damage-associated molecular patterns #metaDAMPs in health & disease! authors.elsevier.com/a/1nYgP…
Sreya Ghosh retweeted
A new PAMP, a new innate immunity principle and a new preclinical application. I am so pleased to share our study on STING activation mechanisms in health and disease. Led by the fantastic Stephanie Ragland, follow the summary below for all we learned.
cell.com/immunity/fulltext/S…
Sreya Ghosh retweeted
Reminder last day to submit your #abstract! registration for the meeting stay #free and #open. If you're coming to the @CytokineSociety meeting this fall and you love #IFN lambda, don't hesitate to sign in! ifnlworkshop.org/
Which is the best #IFN, and why is it IFN-λ?
If you are also interested in this amazing #cytokine, and you're planning to attend the @CytokineSociety meeting in Glasgow this fall, we have you covered with a #free satellite workshop the 22nd of october.
ifnlworkshop.org/
Sreya Ghosh retweeted
IFNλ works at mucosal surfaces by signaling in epithelial cells and selected immune cells. Zhou, Zhang et al. (hubs.la/Q04nCCfZ0) demonstrate that IFNλ also signals in kidney fibroblasts sustaining renal #fibrosis. @Lo_Zanzi highlights the findings: hubs.la/Q04nC-CF0
Sreya Ghosh retweeted
Which is the best #IFN, and why is it IFN-λ?
If you are also interested in this amazing #cytokine, and you're planning to attend the @CytokineSociety meeting in Glasgow this fall, we have you covered with a #free satellite workshop the 22nd of october.
ifnlworkshop.org/
Sreya Ghosh retweeted
Check the #ResearchBriefing @kjena21 & I wrote about our paper @NatImmunol doi.org/10.1038/s41590-026-0… & enjoy some “behind the paper” highlights! 👉👉👉 rdcu.be/flbA1
#InterferonPower! #InflammasomePower! 💥With @kjena21 &co we show @NatImmunol that our fungal adjuvant #Mannadjuvant, via IL1 & IFNs, prolongs & potentiates protection of #mRNA #vaccines, broadening it to new variants & overcoming antigenic imprinting! 👉 nature.com/articles/s41590-0…
