Group leader. Cell Biologist. Electron microscopist. @IMBatUQ. Views my own. (He/Him)
Brisbane, Queensland
Joined June 2018
- Tweets39
- Following228
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Nick Ariotti retweeted
Nick Ariotti retweeted
Thrilled to share our findings on NINJ1 autoinhibition, now online in @Nature. Big thanks to the amazing team @dixitvishva @Melissa_Truong @DrMCJohnson @AlexisRohou and many others. Video by the talented, twitterless Sergei Pourmal (1/3)
Nick Ariotti retweeted
Our latest work on DPANN archaea is now published in the ISME Journal (pubmed.ncbi.nlm.nih.gov/3911…). Using cryoET, we discovered an enormous attachment organelle in the DPANN cell envelope that forms a cytoplasmic bridge between the host and DPANN cells.
Nick Ariotti retweeted
Precision in situ cryo-correlative light and electron microscopy of optogenetically-positioned organelles journals.biologists.com/jcs/…
Achieving optical transparency in live animals with absorbing molecules | Science science.org/doi/10.1126/scie…
Nick Ariotti retweeted
I am thrilled to share that our manuscript on using LEA proteins to prevent air-water interface damage to fragile samples for cryo-EM is offically out!
doi.org/10.1038/s41467-024-5…
Nick Ariotti retweeted
Thrilled to share progress on Ras isoform binders! Using AI-driven protein design, I’ve targeted the challenging, highly charged and disordered C-terminus of Ras. These de novo binders exceed antibody specificity and effectively disrupt Ras signaling. biorxiv.org/content/10.1101/…
ALT Design pipeline for making Ras isoform binders.
Nick Ariotti retweeted
We are hiring! 2 #postdoc #positions in advanced infection models and in data-driven #virology tba on Sept 4th at tinyurl.com/2bdvs7yk Join an enthusiastic and international team of virologists @MedUniInnsbruck in beautiful Tyrol. Join the club of those who #lovevirology
Nick Ariotti retweeted
Thrilled to see our Lifeact-EGFP quail published @JCellBiol after a fantastic and speedy editorial process. This was a great team effort from the whole lab @IMBatUQ but especially @Yanina61831716 with support from @MariseVan2905 & @wang_jianxiong. #Biology
A new transgenic Lifeact-EGFP quail to investigate #actin dynamics during #morphogenesis in a higher vertebrate from Alvarez, @MelanieDWhite et al. @IMBatUQ. Perfect for hi-res imaging of the actin cytoskeleton from subcellular to tissue scale in vivo. hubs.la/Q02D1bpR0
Nick Ariotti retweeted
Will it be the next #antibiotic? A lasting treatment for #ChronicPain? A new way to stop #cancer in its tracks or a novel insight into the #genome?
Do your #PhD at IMB and join some of the world's best to see what you will discover.
🔍 Explore now: bit.ly/3VF2N4A
Nick Ariotti retweeted
Our mini-review of the recent reports revealing the architecture of the Commander complex is online.
s.gwdg.de/s6BN9g
Nick Ariotti retweeted
Congratulations to our researchers who have been awarded @nhmrc 2024 Investigator Grants to address health challenges.
◾ A/Prof Frederic Gachon (@GachonLab)
◾ Prof Glenn King (@VenomsLab)
◾ Dr Marina Naval Sanchez (@MarinaNaval)
◾ Dr Hana Starobova (@starobova)
Nick Ariotti retweeted
This work was led by outstanding postdocs Kevin Chen, Vikas Tillu, Navin Gopaldass, Sudeshna Chowdhury, and with amazing assistance from Juanfang Ruan at the UNSW Microscopy unit. @KevinCh33957486 @Vikas7896 @CryoRetromer @KovtunOleksiy @AriottiNick @IMBatUQ @UQ_News. 2/n
Nick Ariotti retweeted
LYTACs pioneered by @CarolynBertozzi opened the door to degradation of cell surface and extracellular proteins through lysosomal targeting. Here, we introduce genetically-encoded LYTACs, or GELYTACs, which are (1) easier to produce by recombinant expression (LYTACs, antibody conjugates to glycopeptides, are harder to make), (2) amenable to engineering via directed evolution, and (3) possible to secrete from therapeutic cells such as T-cells.
We demonstrate degradation of various soluble targets, including TGFb, IL6R ectodomain, and mCherry with GELYTACs optimized via yeast display directed evolution, added either as recombinant protein or secreted from living T-cells.
Congratulations to lead author @Jony_theChemist, our wonderful collaborators Sean Yamada-Hunter, @LouaiLabanieh and @molecular_elena from the @mackalllab, and great teaming up again with the formidable @CarolynBertozzi.
pnas.org/doi/10.1073/pnas.23…
Nick Ariotti retweeted
Happy to announce that our efforts to establish elemental mapping for cryo-EM ❄️ by EELS 🌈 are now shared on bioRxiv: biorxiv.org/content/10.1101/…
Congratulations to @zoliviapg and co-authors!
But wait - Can we map elements in 3D?
🧵👇 1/6
Nick Ariotti retweeted
Many kinds of endosomes exist in cells that organise transport. Cargoes move from one kind to another as part of their itinerary. How do they do it so efficiently? Our latest #preprint is out biorxiv.org/content/10.1101/… detailing how very early endosomes mature in a robust manner.
'Can we separate hallucinations and the antidepressant effects of psychedelics?' on @lets_experiment experiment.com/projects/can-…
Fundamental research is important! Greg and Jack are looking to develop new antidepressants from psychedelics.
Nick Ariotti retweeted
I’m delighted to share our work @alanbrownhms on the structures of axoneme, one of the largest macromolecular machine in nature! This is really a dream coming true! Now we have an atomic view of the core of cilia skeleton. nature.com/articles/s41586-0…
Nick Ariotti retweeted
Antibody binding reports spatial heterogeneities in cell membrane organization buff.ly/3MpMnHw (@NatureComms)