@AntoranLab

CRUK-RadNet and ARAID IIS Aragon labs. Cell competition mechanisms, Clinical responses and Tumour development/evolution using 3D human Epithelioids

 Cambridge, UK and Zaragoza, ES
gurdon.cam.ac.uk/people/david-fernandez-antoran
Joined May 2020
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🚨#Preprint alert! @antoranlab in close collaboration with @imartincorena lab How can we study human #epithelial tissues for months in the lab, while preserving their native structures and behaviour but without passaging? biorxiv.org/content/10.64898…

Human 3D epithelioids enable continuous long-term clonal evolution studies across multiple epithe...

Modeling human epithelia in vitro remains challenging because current systems do not fully preserve the combination of architecture, heterogeneity, clonal composition, and long-term dynamics shown in...

biorxiv.org
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"The next 25 years of cancer research: emerging perspectives and priorities" nature.com/articles/s41568-0…

The next 25 years of cancer research: emerging perspectives and priorities

Nature Reviews Cancer - To mark the 25th anniversary of Nature Reviews Cancer, six emerging cancer researchers share their perspectives on the future of the field, highlighting conceptual...

nature.com
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"Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species" science.org/doi/10.1126/scie…

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data...

science.org
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"An expanded codebook of human transcription factor DNA-binding specificity" nature.com/articles/s41586-0…

An expanded codebook of human transcription factor DNA-binding specificity

Nature - Results from a panel of assays that analyse different aspects of DNA sequence specificity reveal more than 100 new motifs to aid the characterization of putative human transcription factors.

nature.com
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Special thanks to all the #tissuedonors, their families and #patients who generously allowed us to use human samples to carry out this work. None of this would have been possible without their contribution. THANK YOU!
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Many thanks to the Cambridge Biorepository for Translational Medicine (CBTM, @KSaebParsy, Krishnaa T. Mahbubani, Jack Martin) @AJSchuhmy, @roserventotormo, Rajesh Jena, Gillian C. Barnett and all our collaborators for their fantastic work and support.
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