@AndyTerker

kidney scientist, physician, views are my own

 Nasvhille, Tn
Joined April 2021
  • Tweets48
  • Following54
  • Followers138
🔥 off the press! It’s not just epithelial cells that respond to low potassium 🥑 intake. Learn how kidney macrophages are involved! pubmed.ncbi.nlm.nih.gov/3929…
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There’s a whole world of K-rich foods few people think about. Spread the word!
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Andy Terker retweeted
Patrick Hu@patrickhu13 Aug 2024
Low potassium ‘turns on’ kidney proximal tubule: study news.vumc.org/2024/08/05/low…

Low potassium ‘turns on’ kidney proximal tubule: study

A kidney protein that responds to low levels of blood potassium — which can cause high blood pressure and cardiovascular problems — may be a target for new therapeutics.

news.vumc.org
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Just out! Our new work identifies how KS-WNK1 deletion along the DCT affects NCC. Vanderbilt physiology at its best! journals.physiology.org/doi/…

Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance | American Journal of...

Dietary potassium deficiency causes stimulation of sodium reabsorption leading to an increased risk in blood pressure elevation. The distal convoluted tubule (DCT) is the main rheostat linking plasma...

journals.physiology.org
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Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2 | ⁦@NatureComms⁩ ⁦@AndyTerker⁩ nature.com/articles/s41467-0…

Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2

Nature Communications - The renal epithelium is sensitive to changes in blood K+. Here, Zhang et al. identify low K+ as a potent activator of proximal tubule mTOR/AKT signaling, which occurs...

nature.com
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Thanks to our fantastic team who all contributed to this work on how dietary potassium affects the proximal epithelium! nature.com/articles/s41467-0…

Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2

Nature Communications - The renal epithelium is sensitive to changes in blood K+. Here, Zhang et al. identify low K+ as a potent activator of proximal tubule mTOR/AKT signaling, which occurs...

nature.com
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Don’t forget that Andy Terker first laid out the on switch and Jan Loffing the off. cell.com/cell-metabolism/ful… and kidney-international.org/art…

Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage...

Terker et al. show that dietary potassium deficiency stimulates renal NaCl reabsorption, even in the setting of high salt intake, by hyperpolarizing distal convoluted tubule cells and reducing cell...

cell.com
Swapnil Hiremath @hswapnil.medsky.social@hswapnil14 Apr 2024
Hoorn Ewout from @erasmus on Salt substitutes It’s about the Potassium switch from @PAWellingMD ! Read our comment on that: ajkd.org/article/S0272-6386(… #ISNWCN
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Wonderful talk, thanks for organizing @VelezNephHepato and for the great talk by @PAWellingMD! Love the reference to the Terker curve @AndyTerker
Juan Carlos Q Velez@VelezNephHepato23 Feb 2024
Brilliant thought-provoking talk by @PAWellingMD @HopkinsMedicine about the fascinating K switch story at the DCT, at the Renal Club Dinner, great way to end day 1 of @ssciweb #SSCI2014 #SRM2024
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Such an honor to give a plenary talk at the @EFSInsideScoop Translational Research Forum today, & hijghlight my #HealthEquity-focused research, addressing kidney dz disparities. Great line up of speakers! @drholowaty @peterrebeiro @AndyTerker etc @VUMCKidney
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This was a long time coming, but is the first of several that will clarify the cell types and states in the kidney. @OHSUNephrology @HibpK @KPMProject
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Andy Terker retweeted
Rob Fenton@rofe606528 Mar 2023
Our latest successful @HibpK collaborative study. Led by @m_stowasser and @Nicole_aH alongside @PAWellingMD @dhekidney @fenton_lab @AndyTerker @MartinWolley the study supports a functional “renal-K switch” in healthy human subjects. kireports.org/article/S2468-…

Randomized Trial on the Effect of Oral Potassium Chloride Supplementation on the Thiazide-Sensitive...

The putative “renal-K switch” mechanism links dietary potassium intake with sodium retention and involves activation of the sodium chloride (NaCl) cotransporter (NCC) in the distal convoluted tubule...

kireports.org
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Replying to @VUMChealth @ASCI
Humbled ans honored to be in such great company @DrMonaMash @AndyTerker @HotSaltsRock @JeeyeonC
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Thank you again to our amazing team for this new story about how low dietary potassium intake contributes to kidney injury. cell.com/cell-reports/fullte…

Kir4.2 mediates proximal potassium effects on glutaminase activity and kidney injury

Terker et al. demonstrate that dietary K+ deficiency causes kidney-specific injury and inflammation. Effects are mediated by the proximal tubule basolateral K+ channel Kir4.2, which promotes ammoni...

cell.com
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.@VUMChealth kidney #scientist, Dr. @AndyTerker, will use his Early Independence Award to blaze new paths through #NIHHighRisk research in chronic #KidneyDisease. Want to learn more about his work? bit.ly/3SBQ9zA.

Vanderbilt’s Terker wins NIH Director’s Early Independence Award

Andrew Terker, MD, PhD, a physician-scientist at Vanderbilt University Medical Center who is committed to advancing the understanding and treatment of kidney disease, has received a 2022 National...

news.vumc.org
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Did you know the @NIHDirector’s Early Independence Award supports junior #scientists to launch independent careers? Take a look at how this year’s awardees are “skipping the postdoc” & will pursue their own #biomedical & #BehavioralResearch: bit.ly/hrhreia2022. #NIHHighRisk
Collage of 2022 NIH Director's Early Independence Awardees.

ALT Collage of 2022 NIH Director's Early Independence Awardees.

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BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”
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Andy Terker retweeted
JASN_News@JASN_News22 Jul 2022
While effects of plasma potassium on cardiac arrhythmias are well-documented, studies suggest potassium-rich diets may delay progression of CKD. This Perspective comments on a clinical trial that assesses the impact of supplementing dietary potassium bit.ly/j2022070743
Proposed pathways through which potassium supplementation and potassium-rich diets can help to reduce cardiovascular and kidney disease, age-related bone loss, and kidney stones.

ALT Proposed pathways through which potassium supplementation and potassium-rich diets can help to reduce cardiovascular and kidney disease, age-related bone loss, and kidney stones.

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Congratulations to @kensuke1122333 and the rest of our @VUMCKidney @VUMC_Medicine @VUMC_MedPSTP team on our recent jci insight publication. insight.jci.org/articles/vie…
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Andy Terker retweeted
AJP Renal@AJPRenal21 Apr 2021
Check out #AJPRenal new feature :First Author Spotlight", in the April issue. 👉🏽ow.ly/5prD50EtZj6 #FirstAuthorSpotlight
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.@AJPRenal #APSselect study finds low oxygen-sensing pathways can protect against acute kidney injury after #HeartAttack, but worsened #ChronicKidneyDisease. Read press release and watch author interview with @AndyTerker: ow.ly/5hbA50EhxyB CC: @AJPRenalEIC
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