Postdoctoral Fellow @broadinstitute @insitubiology (Chen Lab) @HSCRB . Ex: @SangerInstitute @Cambridge_Uni @UniofOxford. He/him IG: @ajcrscience
Cambridge, MA
Joined July 2009
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Slide-tags adds spatial coordinates to single-cell sequencing measurements!
Please explore the paper, published online today in @Nature!
nature.com/articles/s41586-0…
Excited to share a short article I wrote describing: Slide-tags - which enables spatial single-nucleus sequencing, allowing us to dive deeper into the complexity of tissue organization. Grateful for the amazing team and support from @insitubiology and @macosko! #ToolsOfTheTrade
Slide-tags enables spatial single-nucleus sequencing
go.nature.com/48x06XP #ToolsOfTheTrade by Andrew J. C. Russell @AndyRusss @broadinstitute @insitubiology @HSCRB
It was such a pleasure to meet everyone this past week in Heidelberg and be part of such a vibrant scientific community - thank you @EMBOFellows!
More than 100 @EMBOFellows are meeting in Heidelberg. The postdoctoral fellows present their research, attend a mentoring session, receive training on a variety of topics and more. #EMBOat60
Had fun talking about Slide-tags with @GenomeTDCC recently. Please check it out If you'd like an overview on what is is and what it can do! 🧬
Slide-tags: Combining single-nucleus genomics with spatial measurements 🧬🔬
Hear from @AndyRusss, @jacksonweir4, Naeem Nadaf, and @insitubiology as they describe the development and application of this impressive technology
youtu.be/4TJkLI4LINU
Andy Russell retweeted
We are happy to share our latest long-range, programmable mutagenesis toolbox - the Helicase-Assisted Continous Editing (HACE) system - to achieve target-specific mutagenesis of the endogenous genome. (1/11)
biorxiv.org/content/10.1101/…
Andy Russell retweeted
Slide-tags unifies the single cell + spatial genomics worlds. It solves three key problems with existing spatial methods:
1) Cell segmentation (the biggest problem)
2) robustness and scalability (well-powered case-control studies now possible)
3) Multiomics (ATAC, RNA, etc)
A new method called Slide-tags lets scientists capture both genetic and location information of individual cells using standard single-cell workflows in the lab. The technology builds upon Slide-seq, both developed by the labs of @insitubiology & @macosko. broad.io/slide-tags
This wouldn’t have been possible without a fantastic team: @jacksonweir4*, @Naeemnadaff*, Matthew S, Vipin K, @SandeepKambham2, @RuthRaichur, Gio M, @soph_liu, @KarolBalderrama, Charles V, @Vignesh_Shan, @Luyi_T, Catherine W, Bryan I, Charles Y, @macosko†, @insitubiology†
Discover more in my original preprint thread here:
xitter.cf/AndyRusss/status/16432…
Single-cell or spatial?
Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics
➡️ doi.org/10.1101/2023.04.01.5…
Single-cell or spatial?
Our new technology - Slide-tags - allows both in the same experiment, enabling true single-cell multi-modal spatial genomics
➡️ doi.org/10.1101/2023.04.01.5…
Please check out the preprint which contains a lot more information, and links to the data! Thank you to everyone at @broadinstitute and @HSCRB who made this possible! @EMBO for funding me.
This was a really fun collaborative project with with: @jacksonweir4*, @Naeemnadaff*, Matthew S, Vipin K, @SandeepKambham2, @RuthRaichur, Gio M, @soph_liu, @KarolBalderrama, Charles V, @Vignesh_Shan, @Luyi_T, Catherine W, Charles Y, @macosko†, @insitubiology†
Andy Russell retweeted
Andrew Russell on Slide-Tags: single-nucleus high-resolution multi-modal spatial genomics #AGBT23
Proud to announce that our paper is out now➡️ doi.org/10.1016/j.chom.2022.…
We explored how malaria parasites differentiate from asexual replication into sexual cell types ♂️♀️ - please see Theo's excellent 🧵 below for more info and acknowledgements!
Now out in journal form: sciencedirect.com/science/ar…
Malaria parasites replicate asexually in the bloodstream, however a subset form ♂️ and ♀️ sexual cell types that when sucked up by a 🦟 undergo sexual reproduction. But how?
🧵
Proud to announce that our paper is out now➡️ doi.org/10.1016/j.chom.2022.…
We explored how malaria parasites differentiate from asexual replication into sexual cell types ♂️♀️ - please see Oliver's excellent 🧵 below for more info and acknowledgements!
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