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I've said many times mechanical hypertrophy is harmful for our health because it suppresses metabolic adaptation via JNK. You have more muscle at the expense of your health (mitohondria).
link.springer.com/article/10…
karger.com/ger/article-abstr…
frontiersin.org/articles/10.…
Time course of muscle hypertrophy with and without progressive overload
pubmed.ncbi.nlm.nih.gov/4288…
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Anabolic inequality among whole protein foods
cdnsciencepub.com/doi/10.113…
In @eLife: The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch doi.org/10.7554/eLife.107597…
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Why do large dogs tend to live shorter lives than their smaller counterparts?
The answer may be written into their epigenome, according to a new study in Science. The findings reveal that larger and male dogs undergo accelerated molecular aging, with pronounced DNA methylation on the X chromosome and at transposable elements.
Learn more: scim.ag/3VZtl3f
ALT A flowchart of the Dog Aging Project. It includes graphics of dogs, DNA, and data charts. Part A shows dog graphics with stars indicating enrollment locations. Part B features a chart of dog ages by size. Part C has box plots for types of dogs. Part D displays a graph of methylation changes over years.
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More sets ≠ more gains. 💪
A 12-week study in trained women found no significant advantage of increasing training volume every 2 vs. 4 weeks for muscle growth or strength.
Progression doesn’t always require more sets.
researchgate.net/publication…
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Longer lipids mark aging and constrain lifespan
👉 “… we identify elongation of lipid acyl chains as a conserved hallmark of aging across mice, Caenorhabditis elegans, Drosophila and humans.
Similar lengthening occurs during the progression of human heart disease, whereas dietary restriction shortens cardiac lipids in mice.
Integrated analyses reveal that aging is characterized by a shift toward longer lipids accompanied by depletion of shorter species, indicating ratiometric remodeling.
Following this, we identify the lipid remodeler Plb1 as a regulator of this process, with expression correlating with lifespan in mice and genetic analyses supporting a causal role in human frailty.
In C. elegans, Plb1 knockdown reverses lipid elongation and extends lifespan in a lipid-length-dependent manner.
Together, these findings establish lipid chain length remodeling as a conserved, actionable hallmark of aging.”
👨🏻⚕️nature.com/articles/s43587-0…
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Recent paper from our group on muscle growth and local muscular endurance
link.springer.com/article/10…
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The Power of Analytical Meditation - His Holiness the Dalai Lama shares how decades of analytical meditation gradually transformed his own emotions, until attachment and anger nearly disappeared. The key, he explains, is not prayer but investigation: examining different, even opposing views and making full use of our intelligence to train the mind. Video originally recorded on February 5, 2017.
Acute Molecular and Chronic Vastus Lateralis Adaptations to Lengthened Partial versus Full Range of Motion Resistance Training in Trained Men ovid.com/10.1249/MSS.0000000…
Regional Hypertrophy of the Gluteal Muscles Is Task-Specific: Differential Responses to 10 Weeks of Hip Extension Versus Hip Abduction Training ovid.com/10.1519/JSC.0000000…
Elbow Flexor Adaptations to Failure Versus Repetitions-in-Reserve Training: A Unilateral Within-Participant Study in Resistance-Trained Adults mdpi.com/4056724 #mdpimuscles через @MDPIOpenAccess
Alex retweeted
Randomized controlled trial of resistance exercise and brain aging clocks
"Resistance exercise training decelerates brain ageing, as indexed by brain clocks, reinforcing its role as a preventive strategy for brain health."
link.springer.com/article/10…
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Contraction type dependence of serial sarcomere addition following resistance training biorxiv.org/content/10.64898…
Comparison Between Eccentric-Concentric and Eccentric-Only Dumbbell Arm Curl Exercise Training for Their Effects on Neuromuscular Adaptations
pubmed.ncbi.nlm.nih.gov/4283…
tandfonline.com/doi/full/10.…
Exercise-specific preferential hypertrophy of individual elbow flexor muscles after incline versus preacher dumbbell curl training
Alex retweeted
Music helps soothe the brain when we are stressed
Music doesn’t just mask stress; it guides our brains back to a calm state
scientificamerican.com/artic…
Effects Of Isometric Complex Training At Short And Long Muscle-Tendon Unit Lengths On Muscle Architecture ovid.com/10.1249/01.mss.0001…
Split-set resistance training in-season increases maximal vertical power without enhancing athletic performance: a comparison with failure training in youth handball players
minervamedica.it/en/journals…
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Women who delivered very preterm had vitamin D levels about 25% lower than women who delivered at term.
Average 25(OH)D was 26.2 ng/mL among births before 32 weeks, compared with 34.8 ng/mL at term. Women delivering between 32 and 36 weeks also had lower levels, averaging 31.3 ng/mL.
Vitamin D is involved in placental biology and immune and inflammatory regulation - pathways that could plausibly influence the timing of birth. And the pattern of progressively lower vitamin D with earlier delivery strengthens the case for testing whether optimizing maternal vitamin D status can improve pregnancy outcomes.
