@AlexGuetMcC

Postdoc in neuroscience

 Toronto
Joined May 2014
  • Tweets18
  • Following145
  • Followers75
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Thrilled to share our latest publication on predicting optimal doses of α5-GABAA receptor modulators for depression treatment using EEG biomarkers and computational models. #Neuroscience #Depression #ComputationalBiology #MachineLearning #EEG doi.org/10.1371/journal.pcbi…

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity

Author summary Inhibition from somatostatin-expressing (SST) interneurons is reduced in depression, and new pharmacology (α5-PAM) can selectively recover this inhibition to healthy level. However,...

journals.plos.org
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Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Alex Guet-McCreight retweeted
Cell Reports@CellReports12 Apr 2024
Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition memory dlvr.it/T5RDx8

Mouse hippocampal CA1 VIP interneurons detect novelty in the environment and support recognition...

Tamboli et al. discover “novelty cells” in the mouse hippocampal CA1 area that belong to a family of vasoactive intestinal polypeptide-expressing interneurons (VIP-INs). In freely behaving mice,...

cell.com
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EEG biomarkers of GABA α5 positive allosteric modulators in rodents biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Alex Guet-McCreight retweeted
CAMH Research@CAMHResearch23 Feb 2024
New CAMH-led research in @CommsBio shows targeting specific brain cells could be a game-changer for treating depression. By simulating pharmacology effects in humans, scientists are getting closer to more effective treatments. ⬇️MORE: doi.org/10.1038/s42003-024-0…
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My Cerebral Cortex article finally moved from early release to an issue release (doi.org/10.1093/cercor/bhac3…). Here is some nice cover art by Amanda Sherrington (galleriesherrington.ca/) that we had hoped to publish alongside it (not selected, unfortunately).
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Alex Guet-McCreight retweeted
Shreejoy Tripathy@neuronJoy16 Nov 2022
I'm really proud to share this data paper on some of our human neuron intrinsic ephys work with @DrValiante, @moradi_homeira, and @internautderek that is now out at @GigaScience! academic.oup.com/gigascience…
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Excited to share this collaborative work, now in its final form: Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity. @CAMHResearch @KBI_UHN #aging doi.org/10.1093/cercor/bhac3…

Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity

Abstract. Aging involves various neurobiological changes, although their effect on brain function in humans remains poorly understood. The growing availabi

academic.oup.com
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New work with @Kant_Yao: Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits. 🥳doi.org/10.1016/j.celrep.202…
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Alex Guet-McCreight retweeted
Sean Hill@wake_sleep4 Nov 2021
New neuron modeling study on electrophysiological changes in aging from the lab of Etay Hay and collaborators @neuronJoy @DrValiante Age-dependent increased sag current in human pyramidal neurons dampens baseline cortical activity biorxiv.org/content/10.1101/… #KrembilNeuroinformatics – at Toronto, Ontario

Age-dependent increased sag current in human pyramidal neurons dampens baseline cortical activity

Aging involves various neurobiological changes, although their effect on brain function in humans remains poorly understood. The growing availability of human neuronal and circuit data provides...

biorxiv.org
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Alex Guet-McCreight retweeted
JNP@JNeurophysiol13 Aug 2021
#ArticlesinPress - "Deciphering how interneuron specific 3 cells control oriens lacunosum-moleculare cells to contribute to circuit function" Alexandre Guet-McCreight and Frances K Skinner #Dendrites #Ionchannels #Neuroscience @UofT ow.ly/CTwP50FPXaO
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Alex Guet-McCreight retweeted
Frances Skinner@francesskinner21 Sep 2020
Excited to share submitted work with @AlexGuetMcC on virtual inhibitory network modeling biorxiv.org/content/10.1101/… - made possible by building on collaborative work doi.org/10.3389/fncel.2020.0… and doi.org/10.1093/cercor/bhz33… and more! #KCNhub @KrembilRI

Deciphering how specialized interneuron-specific cell types contribute to circuit function

The wide diversity of inhibitory cells across the brain makes them fit to contribute to network dynamics in specialized fashions. However, the contributions of a particular inhibitory cell type in a...

biorxiv.org
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Deciphering how specialized interneuron-specific cell types contribute to circuit function biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Alex Guet-McCreight retweeted
Krembil Brain Institute@KBI_UHN10 May 2017
UofT CPIN joins us to a packed house for Dr. Eve Marder's keynote talk at #Krembil Research Day
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Alex Guet-McCreight retweeted
nature
@Nature24 Feb 2017
Giant neuron found wrapped around entire mouse brain like a 'crown of thorns': go.nature.com/2l7Ur1c
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Alex Guet-McCreight retweeted
Neuroscience News
@NeuroscienceNew21 May 2014
Neuroscience's Grand Question neurosciencenews.com/theoret… #neuroscience
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