Gabriela Alejandra Buerba

Lesson #2 of the day: Did you know that liver metastases from insulinoma can have a surrounding area of fatty infiltration/focal steatosis around the metastases? This I did know but perhaps others may not. Here are a couple of images from this months NET clinic. The first image is early phase contrast and the 2nd image is delayed gadoxetate (Eovist) sequence. Clinicians should always look at the imaging studies they order and have a basic understanding of them. No better place to learn than going to tumor board. ajronline.org/doi/10.2214/aj…

We have long known that patients with cystic pancreatic NETs fare better after resection and have lower risk of recurrence. Also, cystic pNETs are less likely to have high-risk features such as nodal metastases. What has been missing is a really large study... We have that now. Multi-institutional study of 1727 patients, including 177 cystic pNETs with comparison across groups. If you take care of patients with pNETs, this is a must read! Key findings include: -- Cystic PanNETs demonstrated significantly fewer high risk histopathologic features -- Lymph node (LN) metastases (5.5% vs 24.0%, P < 0.001) -- Distant recurrence (4.1% vs 14.4%; P <0.001) -- Among tumors, ≤3 cm, cystic PanNETs had a low rate of LN metastases (3.9% vs 17.8%; P < 0.001) -- Recurrence (3.1% vs 8.4%; P = 0.041), and low propensity to recur distantly -- Cystic PanNETs had favorable long-term survival regardless of tumor size. oce.ovid.com/article/0000065… @MVentinMD @jhatjhmi1