@AgostoLab

Assistant professor at Dalhousie University. We study physiology, cell biology, and biochemistry of the retina. Opinions are my own.

 Halifax, NS
Joined April 2022
  • Tweets109
  • Following284
  • Followers180
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A few days left to apply for the Visual Neuroscience position at Dalhousie University in Canada. New deadline Jan 31.
Melina A. Agosto@AgostoLab14 Jul 2024
This could be the view from your office! We're recruiting a #tenuretrack Assistant or Associate Prof in the Retina and Optic Nerve Research Group at Dalhousie University. #Hiring #VisualNeuroscience dal.peopleadmin.ca/postings/…
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New results explain mGluR6 dysfunction in congenital stationary night blindness @DalhousieU @AgostoLab life-science-alliance.org/co…
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Had a great and educational time at #ISER2024 in Buenos Aires!
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That rare and wonderful moment when you test a new commercial antibody and it actually looks good #MicroscopyMonday
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A cautionary tale
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This could be the view from your office! We're recruiting a #tenuretrack Assistant or Associate Prof in the Retina and Optic Nerve Research Group at Dalhousie University. #Hiring #VisualNeuroscience dal.peopleadmin.ca/postings/…
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Sunset in the cell culture room
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New group photo!
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Melina A. Agosto retweeted
Tibor Rohacs@RohacsTibor19 May 2024
Warm conformation of the calcium-activated nonselective cation channel TRPM4 driven by a temperature-dependent calcium-binding site. nature.com/articles/s41586-0…

Physiological temperature drives TRPM4 ligand recognition and gating

Nature - A temperature-dependent Ca2+-binding site in the intracellular domain of TRPM4 is essential for TRPM4 function in physiological contexts.

nature.com
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Researchers have generated a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, giving an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. scim.ag/6WK
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Great to meet up with colleagues old and new at #ARVO2024, and especially cool to meet some of the @alecia144g lab and @RobichauxLab trainees. Bye, Seattle!
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Melina A. Agosto retweeted
Victoria E. Abraira@VAbraira5 May 2024
🚀 Exciting opportunity! Our lab at Rutgers University is now hiring a postdoctoral researcher. Join us to explore the mysteries of the somatosensory system using cutting-edge molecular genetics. Apply now! 🧬🔬 abrairalab.org/join-our-team…
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First paper from the Agosto lab is out! Co-authored by undergraduate students Michael Miller and Mustansir Pindwarawala. We showed that N-glycosylation is important for mGluR6 interactions with ELFN proteins and localization in retina. doi.org/10.1016/j.jbc.2024.1…
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Thank you to my fantastic students for all of your hard work in 2023!
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Melina A. Agosto retweeted
Michael Robichaux@RobichauxLab9 Jan 2024
Our lab's super-resolution #microscopy analysis of #rhodopsin in the complicated/hard-to-reach #photoreceptor inner segment compartment is now published in @PLOSBiology !! 🔬👁️ Special thanks to all co-authors, including @AgostoLab
PLOS Biology@PLOSBiology9 Jan 2024
Retinal #photoreceptor cells are maintained through a complex #ProteinTrafficking network. @RobichauxLab use quant super-res microscopy to reveal trafficking of the visual pigment #rhodopsin in the inner segment region of rod photoreceptors #PLOSBiology plos.io/3RPJPVW
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ICYMI, we recently unveiled the first cellular map of a mammalian brain in @nature. 🧠✨ Over 6 years and 32 million cells in the making, the complete adult mouse brain cell-type atlas reveals amazing diversity & regional specificity. More: alleninstitute.org/scientist… #studyBRAIN
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Melina A. Agosto retweeted
eLife - the journal@eLife20 Dec 2023
For the first time, scientists analysed the connectome for part of the brain in the common octopus involved in long-term memory. Here, they use #ElectronMicroscopy to trace the length of an axon micron by micron. #12DaysOfeLife elifesciences.org/articles/8…
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I'm very pleased to have been awarded a Young Investigator Grant from the Alcon Research Institute. This grant will help fund our project about synaptic protein trafficking in photoreceptors and bipolar cells. Thank you!! alcon.com/ari-grant-recipien…
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Melina A. Agosto retweeted
SfN Journals@SfNJournals2 Nov 2023
#eNeuro | Ultrastructural Characteristics and Synaptic Connectivity of Photoreceptors in the Simplex Retina of Little Skate (Leucoraja erinacea) eneuro.org/content/10/10/ENE…

Ultrastructural Characteristics and Synaptic Connectivity of Photoreceptors in the Simplex Retina...

The retinas of the vast majority of vertebrate species are termed “duplex,” that is, they contain both rod and cone photoreceptor neurons in different ratios. The retina of little skate ( Leucoraja...

eneuro.org
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Melina A. Agosto retweeted
Abi Moye@abi_moye9 Oct 2023
Thrilled to share the latest work from my time at #BCM in Ted Wensel’s lab and with @AgostoLab, ‘Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography’ giving us a closer look at the CC, including y-links! biorxiv.org/content/10.1101/…
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