Transcription and RNA processing; postdoc in @STOPlabPI group @UAM_IBMiB
Joined March 2020
- Tweets75
- Following202
- Followers157
- Likes185
Agata Stepien retweeted
New paper in @embojournal!
@AgataKStepien, @DPulimamidi & @STOPlabPI reveal that RNA cleavage and transcription termination shift in opposite directions in colorectal cancer cells. Their proximity is linked to gene expression and cancer cell vulnerability! link.springer.com/article/10…
Agata Stepien retweeted
Primary and metastatic colorectal tumor cells share a common origin, but do they share the same vulnerabilities?
Surprisingly, primary cells depend far more on #PCF11 and #CPSF73, two pre-mRNA processing/termination factors.
Our latest study explores why: tinyurl.com/3pkeuctp
Two steps in gene expression that should move together…don’t. In our new paper we show that pre-mRNA cleavage and RNA polymerase II (RNAPII) termination shift in opposite directions – with a surprising link to gene expression and cancer cell vulnerability tinyurl.com/3pkeuctp
5. Many thanks to @STOPlabPI, @DPulimamidi, @real_lab_duck, Maxime Lalonde, @kopczynska_m, Klaudia Ostatek, Mariia Kapeliukha, Shazia Irshad, Hiroshi Kimura, @michal_gdula, and Stephan Hamperl for a great collaboration on this project. tinyurl.com/3pkeuctp
Studying gene ends is becoming even more fascinating❗️ Curious why❓ Read our News & Views "Transcriptional readthrough progresses from incidental byproduct to therapeutic opportunity" inspired by the recent publication from Podszywałow-Bartnicka and Karla Neugebauer @NatureSMB
Did you know that changes in pre-mRNA 3' cleavage and RNAPII termination can go in different directions? Even more, the spacing between these two events is linked to the gene expression level❗️Check out our latest pre-print to learn more tiny.cc/330w001 1/6
4. Shortening of the distance between pre-mRNA cleavage and RNAPII terminal pausing is associated with higher gene expression❗️
Shortened spacing = higher expression BUT also higher addiction to PCF11 and CPSF73. 5/6
5. Many thanks to @STOPlabPI , @DPulimamidi, @real_lab_duck, Maxime Lalonde, @kopczynska_m , Shazia Irshad, Hiroshi Kimura, @michal_gdula , and Stephan Hamperl for a great collaboration on this project. 6/6
Agata Stepien retweeted
HIRING! STOP lab is looking for a Research Assistant (Technician) with experience in protein expression and purification @czt_uam @UAM_IBMiB @UAM_Poznan. Job & project description and how to apply here: euraxess.ec.europa.eu/jobs/3…
Agata Stepien retweeted
🚀 We’re hiring a #Postdoc!
Join our group in Poznan, Poland to study meiotic crossover recombination in plants🌱 Highly motivated & enthusiastic candidates are welcome!
📅 Deadline: Nov 1, 2025
🔗 ibmib.web.amu.edu.pl/wp-cont…
#PlantScience #Meiosis #PostdocJobs
A beautiful story about the role of SETD2 in RNAPII transcription 💗
🚨New preprint from our labs (STOP lab & Nojima lab @pol2rna)! @kopczynska_m and Chihiro Nakayama have been digging into how chromatin remodeller SETD2 controls the start and end of transcription 👇 (1/5) biorxiv.org/cgi/content/shor…
Agata Stepien retweeted
1/6 Buckle up folks: our new paper in @ScentificReports is out! Interested in insect cells culturing? Together with Ewa Stein @ESte_late, Martyna Plens-Gałąska @real_lab_duck & Kinga Kamieniarz-Gdula @STOPlabPI @UAM_IBMiB & @czt_uam we provide a story about #Sf cells-BEVS system.
