@AgardLab

Structural Biology/Biochemistry Lab @UCSF #cryoEM Tweets by lab members

 San Francisco, CA
msg.ucsf.edu/agard-lab
Joined October 2020
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Thank you to the bargaining teams for all their hard work! #UnionStrong @UAW
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Check out our latest preprint showing that the major protein enclosing the Phage Nucleus (PhuN) forms a tetrameric lattice with C2 symmetry. The symmetry establishes 4 unique interfaces, two large enough to act as channels for small molecules, RNA, or even unfolded proteins.
Eliza Nieweglowska@ENieweglowska7 Apr 2022
Excited to share our findings about the self-assembly of the phage nucleus! In short: it’s primarily composed of a single ~70 kDa protein and forms a beautiful (I may be a little biased 😍) C2 symmetric lattice! biorxiv.org/content/10.1101/…

The ϕPA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice

A growing number of jumbo bacteriophages, with genomes exceeding 200 kb, have been found to establish a Phage Nucleus—a micron-scale, proteinaceous structure encompassing the replicating phage DNA....

biorxiv.org
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Thank you, @SnitchcockScav, for the lovely watercolor of one of our figures! #SnitchcockScav @UChicagoScav #Item68 nature.com/articles/s41586-0…
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