@AgamiLab
Joined September 2021
  • Tweets21
  • Following79
  • Followers173
4Media
The Agami Lab retweeted
Elizabeth McKenna@ElizSMcKennaMar 4
The new @CancerGrand Challenges teams have just been announced! Read about the teams tackling cancer avoidance, mechanisms driving mutational signatures, the dark proteome, cancer neuroscience, and rewiring cancer cells now in @CD_AACR: aacrjournals.org/cancerdisco…
4
11
1
38
5,423
Team ILLUMINE, featuring our Hannon Group, will receive up to $25m over five years to take on the challenge of the dark proteome as part of Cancer Grand Challenges. Full story: cruk.cam.ac.uk/news/hannon-g…
1
5
394
The Agami Lab retweeted
Champagne@Jchmpg23 Mar 2025
We are hiring! Come and work with us from aberrant mRNA translation to innovative treatment opportunities. #agamilab #Bioinformatics #NKI nki.nl/careers-study/vacanci…
1
147
The Agami Lab retweeted
Immunity@ImmunityCP3 Jan 2025
Online now: Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation dlvr.it/TH8WR8
1
17
77
4,675
It has been a long journey since we first uncovered defective translation in cancer upon amino acid shortage in 2019 and today where we have been finally able to target cancer cells by adoptive T cell therapy against those aberrant peptides.
1
1
2
208
Hopefully more T cell Receptor will be identified and more clinical applications will follow. A big thanks to the all Agami Lab and to our collaborators and fundings that have been essential to achieve this work. @JOlweus @oncodeinstitute @NKI_nl
1
2
3
453
Please have a look to our new publication in Immunity. cell.com/immunity/fulltext/S… (@ImmunityCP )!

Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA transl...

Interferon γ secretion by activated T cells alters the immunopeptidome landscape of cancer cells, enriching for W>F substitutant epitopes. Champagne et al. demonstrate that these induced neoepitopes...

cell.com
6
1
15
2,866
We are happy to announce that our group is among the three groups from the @NKI_nl that will receive the prestigious @ERC_Research Advanced Grant! This grant will support our goal of detecting and exploiting changes in the protein landscape of cancer. ➡️ bit.ly/4aMY4mi
3
12
335
We are thrilled to enounce the selection of our principle investigator Reuven Agami as a new member of @_knaw for his "series of highly original and high-impact discoveries"! lnkd.in/d9PxWRnq
2
2
17
1,643
Congratulations to @abhipataskar42 for being awarded the highly prestigious annual AvL prize for the most talented young researcher of the NKI. We are all very proud👏
1
2
22
1,378
We are excited to share our recent review published fresh in Molecular Cell. It highlights recent advance on various protein diversification events by mRNA translation in cancer. #cancer #molecularcell #AcademicTwitter #mRNAtranslation #Cell cell.com/molecular-cell/full…

Proteome diversification by mRNA translation in cancer

In this issue of Molecular Cell, Kochavi et al. review recent findings describing how diverse mRNA translation mechanisms elicit cancer-specific protein diversification. Particular attention is paid...

cell.com
3
10
A great Research Highlight by @lisa_heinke on our recent publication.
This Post is from an account that no longer exists. Learn more
6
The Agami Lab retweeted
Yuval Malka@YuvalMalka1723 Oct 2022
How well do we understand the complexity of the transcriptome? in our new study (@AgamiLab, @alkan_ferhat, @liamfaller, and more), we uncover an unexpected function of cleavage and polyadenylation, which generates thousands of novel uncapped mRNA isoforms! authors.elsevier.com/sd/arti…
3
4
11
We are looking for a talented Postdoc fellow to investigate "sloppiness" in mRNA translation in cancer. More details are below. #academicjobs #postdoc #CancerResearch #sciencejobs
5
1
7
We are very happy to share our recent paper published in Nature. We show that IFN-signaling associated Trp depletion leads to a new class of antigens, i.e Substitutants. Thank you @abhipataskar42 @Jchmpg @JOlweus @BarbMarte @michal_bassani and others.
nature
@Nature9 Mar 2022
Nature research paper: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants go.nature.com/3J1QLJS

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Nature - Tryptophan depletion, which occurs in tumours, results in in-frame translation across tryptophan-encoding codons by phenylalanine substitution.

nature.com
3
5
3
21
We also thank Pavel Baranov and John Atkins for their excellent news and views article, which can be read here; nature.com/articles/d41586-0…

Immune cells alter genetic decoding in cancer

Nature - Tumour cells make proteins that have swapped one amino acid for another.

nature.com
3
We have a postdoc position in bioinformatics at our group at NKI, Amsterdam. Please have a look for more details #nki #oncology #Bioinformatics nki.nl/careers-study/vacanci…
1
4
1
3
The Agami Lab retweeted
Rene Medema@MedemaRene1 Oct 2021
#LIDLbyLIDL: ⁦@LidlNederland⁩ is making a statement, I suggest we all follow; they are the only supermarket I will shop at. nos.nl/l/2399906

Lidl verkoopt per direct geen sigaretten meer

De supermarktketen had al het voornemen om de rookwaren eind 2022 uit de schappen te hebben, maar lost die ambitie eerder in.

nos.nl
3
1
5
Lidl, one of the largest supermarkets chains in the Netherlands, stops selling cigarettes and tobacco. Good move by the German chain. nos.nl/artikel/2399906-lidl-…

Lidl verkoopt per direct geen sigaretten meer

De supermarktketen had al het voornemen om de rookwaren eind 2022 uit de schappen te hebben, maar lost die ambitie eerder in.

nos.nl
1
2
25
Online Now: Oncogene-dependent sloppiness in mRNA translation dlvr.it/S8QmC0

Oncogene-dependent sloppiness in mRNA translation

When amino acids are scarce, cancer cells are prone to produce aberrant protein. Here, Champagne et al. show that these errors result from the hyperactivation of oncogenic pathways. This cancer...

cell.com
16
1
80
Load more