Cancer patients with the same diagnosis often have very different tumor biology. Molecular testing can reveal underlying differences, but that's slow and expensive. Introducing Holon-S1, our platform to predict genes and biomarkers from routine pathology slides. • beats two other models at predicting spatial gene activity in a controlled comparison • has identified potentially novel biomarkers in breast cancer and colon cancer • evaluated across 16 organ types and more than 15 scanners, using slides from both formalin-fixed, paraffin-embedded and fresh-frozen tissue. We believe Holon-S1 has the potential to help researchers find new biomarkers in slides they already have, discover treatment targets, and bring more personalized cancer care within reach!

It's time for personal agents in healthcare. Our system is fragmented and runs on clunky legacy software. That's exactly why agents that can navigate those systems on our behalf could make such an impact. Karan, who leads health AI at OpenAI, calls it "absolutely ripe for agents and computer use" and thinks many of the barriers between patients, clinicians, and their data will dissolve. I agree. Super inspiring convo with my friend @thekaransinghal on how AI can raise both the floor and the ceiling of human health.

Ben Horowitz on treating your story as your strategy, and why founders often skip writing it even though it's one of the most important parts of the job: "The story of the company is also the strategy of the company... In your mind, you're kind of adjusting that strategy a little bit at a time every day. But then a quarter later, it's actually pretty different than what you started with." "So it's really important that you keep upgrading your story. The articulation of your story. I would definitely recommend it be in written form." "Something that you can share with everybody in the company, and everybody you're recruiting, everybody you're trying to raise money from, all your constituents, every customer." "The problem that I think founders have is it doesn't feel like work. Like, 'What are you doing today?' 'I'm working on my story.' That doesn't sound like work." "Because it doesn't feel like work, people don't do it, but it's probably one of the most important parts of the job." @bhorowitz w/ @speedrun GP @Tocelot

Wabi 2.0 is live! personal agents are one person, one chat. but the parts of life that matter run on more than one person Wabi is an agent you use together. you talk to it, it does stuff, builds the apps you need, and anyone can join the thread - your partner, your best friend, the preschool moms groupchat school changes pickup time → Wabi updates the family calendar, everyone sees it. a show you’d both love → Wabi finds a night that works, gets the tickets. the trip everyone keeps talking about → Wabi picks the dates, builds the itinerary, books it go start a thread with your people 👇

Thanks everyone! I just sent X subscription (super tier) codes to a bunch of folks with the most thoughtful replies who aren't already Grok Bot users, including: 1. @AAkerstein wants to use @bot to help cancer patients and caregivers navigate hard medical decisions 2. @narlashreya wants a shared family calendar that finds seasonal events and drops the best ones in 3. @SMB_RealEstate wants to turn local Facebook posts into window blind leads, quotes and booked installs 4. @Vantekai_ wants one place to run an e-commerce brand and a UK football site, instead of dozens of AI chats 5. @santinomics_ wants to run a peanut trading business across Argentina, Paraguay and China with Grok Bot I have a more codes available to my paid subscribers at behindthecraft.com/ and I'm sure we'll run a giveaway like this again at some point.

For the love of g-d. Take a lesson from Israel. You cannot run a modern nation around fear that @Yusuf4Love2002 with 168 followers is going to call you a far-right genocidal fascist if you pick up a gun to save your society. It WILL do just that. Just ignore it, and fight back.

On my way to the office this morning, I passed a group of young people protesting, a Palestinian flag draped over their shoulders. And I asked myself a question I can't shake: why does this generation always fall into the same trap? No matter the history. No matter the context. Even the ones from wealthy families, who went to the best schools, who were dealt every good card. Always the same trap. I don't think it's stupidity. I think it's a mechanism. And a mechanism can be taken apart, piece by piece. A. The observation: everything the state touches becomes unaffordable. Look at economist Mark Perry's famous chart, the one people call "the chart of the century." It tracks US prices since 2000. At the top, what explodes: hospital services, college tuition, textbooks, childcare, housing. Increases of +100%, +150%, up to +250%, far above general inflation. At the bottom, what collapses: TVs, software, phones, toys, clothing. A TV today costs a fraction of what it did in 2000, for an infinitely better product. Look at what separates the two groups. It isn't technology. It isn't complexity. It's one variable: how much the state is involved. At the top, sectors that are subsidized, regulated, shielded from competition, where the state funds demand and blocks supply. At the bottom, sectors where companies fight every single morning to serve you better and cheaper. B. The mechanism: why it's systematic. When the state subsidizes demand without freeing supply, prices rise. Every time. Guaranteed student loans, and universities raise tuition. Housing aid plus blocked building permits, and rents skyrocket. Administered healthcare, and bureaucracy eats the budget before it ever reaches the patient. In France it's even more vicious, because the price doesn't disappear: it hides. You never see the hospital bill, you pay it through payroll contributions. You never see the cost of school, you pay it through taxes. Public spending at 57% of GDP, one of the heaviest tax burdens in the world, more than €3.4 trillion in debt. And the result? Overflowing ERs, falling PISA scores, young people who can't afford to live in the city where they work. The market didn't fail in these sectors. It was never allowed in. C. Suffering demands a culprit. A 22-year-old lives all of this in their bones. They can't find a place to live. Their degree either buries them in debt or opens no doors. The future feels blocked. That suffering is real, and I don't deny it for a second. But human beings can't stand suffering without a culprit. They need a face. A scapegoat. And this is where everything is decided: who taught them how to read the world? D. Whoever tells the story picks the villain. Schools are public. Universities are public. Culture runs on grants. Film goes through funding committees. Public broadcasting shapes the narratives. The people handing down the interpretive framework are, overwhelmingly, paid by the very system that creates the problem. Do you really think that system is going to name itself as the culprit? No. It names the capitalist. The boss. The landlord. "The rich." The multinational. The commercial West. Same role, same casting, every time. E. One lens, a thousand causes. And this brings me back to that flag. A generation taught to read every situation through a single lens, oppressor on one side, rich, Western, capitalist, oppressed on the other, will apply that lens everywhere. To housing. To climate. To conflicts on the other side of the world. The cause changes, the lens stays. That's why the trap is always the same: it's not the cause that draws them in, it's the way of thinking that was installed in them. F. The perfect inversion. Here's the irony. Capitalism is the force that drove down the price of almost everything it touched. The state is the force that blew up the price of almost everything it captured. And young people blame the first for the crimes of the second. It's like blaming the firefighter for the fire because you saw him at the scene. G. The ballot box confirms it. In the US, a few weeks out from the midterms, a large share of urban young voters is getting ready to vote Democrat for more state, more spending, more regulation. New York elected a self-described socialist mayor, carried by young voters, on promises of rent freezes and city-run grocery stores. Rent freezes, the policy that has made housing scarcer everywhere it's been tried. The cure that worsens the disease. In France, it's the same play in two acts. Part of the youth votes for the radical left, which promises more state. Another part votes for the center, which promises to "manage" the state well, and has dug the debt deeper than ever. Two different ballots, one shared assumption: the problem is the market, the solution is the state. H. The way out. These young people aren't stupid. They're right to be angry. They're just aiming at the wrong target. The day they understand that their rent, their tuition and their hospital are expensive precisely because the state runs them, their anger will change direction. They'll stop protesting against those who create. They'll start protesting against those who capture. That day, the greatest intellectual scam of our time will be over.

Marseille city hall has fallen & they have put up Palestinian flags inside

6,000 years of world history on a single timeline. Zoom in. You could spend 30 minutes exploring this.

Marseille city hall has fallen & they have put up Palestinian flags inside

Pedigree is overrated. Grit isn't. Bloomberg on who he'd hire: "the person whose father never was there, whose mother was in a drug treatment program. And he had to go and work three shifts at McDonald's to take care of his siblings." "No matter how bad things are — looks on the bright side, takes the bull by the horns, puts in the sweat capital. That's where the results are."

I got tired of all the spam calls I was getting so I had @bot find my number listed on sites and file the removals. I made it a free skill so you can do the same. x.ai/bot/fUj6TYhiW_cjtzWvbsF… @SpaceXSI @elonmusk

@bot helping cancer is a very worthy cause let's consider Ari

Just a reminder about something I said a few years back: “addiction is a progressive narrowing of the things that bring you pleasure.” “Enlightenment (for lack of a better term) is a progressive expansion of what brings your pleasure.” Are you addicted to something? If so, what?