French researchers have identified a distinct circulating viral community in patients with Crohn’s disease (CD) that may serve as a disease signature. The findings published in Gastroenterology challenge the long-held assumption that blood is sterile and suggest that alterations in the circulating virome may reflect intestinal barrier dysfunction in CD. If confirmed in larger cohorts, these results could open a new avenue for biomarker development in inflammatory bowel disease. mdsc.pe/4tG552t