Beth Zupec-KANIA, RDN, CD retweeted
At the Coalition for Metabolic Health, we're working to address America's chronic disease crisis. Learn more about our mission to make metabolic health mainstream—and hear directly from some of our experts—in our new video:
Beth Zupec-KANIA, RDN, CD retweeted
🚨Amazing new resource from @Metabolic_Mind summarising all the developments in bipolar research in metabolic psychiatry.
Including 10 (!) clinical trials and studies underway for bipolar.
metabolicmind.org/bipolar-di…
We’re 5 days into the Healing Depression retreat and everyone is making ketones ! instagram.com/reel/DHgf7KZxg…
Beth Zupec-KANIA, RDN, CD retweeted
Dr. Lori Calabrese discusses how ketones can revolutionize health by enhancing mitochondrial function. Nothing else in psychiatric care does this quite like it! Watch the full interview for groundbreaking insights. 🎥🧠 #PsychiatricCare
bit.ly/3xnrFVv
Ketogenic Diet, Exercise Effective First-line Treatments for Narcolepsy medscape.com/viewarticle/ket… medscape.com/viewarticle/ket…
Beth Zupec-KANIA, RDN, CD retweeted
Mitochondria increase their activity level when we are having positive life experiences, according to recent research from @CarolineTrumpff & @MitoPsychoBio.
Trumpff spoke with @sciam about the implications of the findings: scientificamerican.com/artic…
Beth Zupec-KANIA, RDN, CD retweeted
PLEASE HELP! Sign this petition.
The Maryland Health Secretary has halted an ongoing, privately-funded, inpatient study of a medical ketogenic diet for treating schizophrenia for no clear reason.
People with schizophrenia deserve better treatments.
chng.it/SbT7zHjNNz
Beth Zupec-KANIA, RDN, CD retweeted
Study Title: Recovery from Mental Illness with Ketogenic Diets: A Qualitative Retrospective Analysis
#ketogenic #research #qualitative #mentalhealthmatters #psychology
mentalhealthketo.com/ketogen…
I agree and have first-hand experience in transitioning women with AN from their high-carb diets to keto with incredible results.
This Post is from an account that no longer exists. Learn more
Beth Zupec-KANIA, RDN, CD retweeted
"Treatment-resistant: These two words should never be used together for mental illness or any illness, because it puts the blame on the patient & on the family. And Matt did not fail treatment, treatment failed Matt. They weren't the right treatments." -@janellison
Tremendous interview with @Metabolic_Mind Co-Founder @janellison Baszucki, who previously joined us with her son, Matt Baszucki (Episode 265).
YouTube - youtu.be/qTi_jHJMNYQ
iTunes - podcasts.apple.com/us/podcas…
Spotify - open.spotify.com/episode/5xH…
Libsyn - lowcarbmd.com/episode-343-ja…
Beth Zupec-KANIA, RDN, CD retweeted
🚨Lean Mass Hyper-Responder #LMHR Overview 🚨
The discussion around LMHR is increasing. That’s good. I wanted to take a moment compile potentially useful links and references. What follows:
👉Review of terms (#LMHR and #LEM)
👉Videos covering the Lipid Energy Model and phenomenon related to #LMHR.
👉10 references to peer-reviewed publications
#LMHR: A phenotype defined by LDL-C ≥ 200 mg/dl, HDL-C ≥ 80 mg/dl, TG ≤ 70 mg/dl.
NOTE: There is no threshold for BMI or body fat. “Lean” refers to the association between this lipid triad and being leaner (see video 4 and ref 4 in list below). More specifically, the LEANER one is on a very low-carb diet, the HIGHER LDL-C tends to be, as part of a high LDL-C, high HDL-C, low TG pattern that constitutes a metabolic fingerprint, of sorts. This appears to be a dose-response relationship.
#LEM Lipid Energy Model is the mode that explains the LMHR phenotype and related phenomenon. It is not “proven,” but has been effective in making accurate bold predictions.
🚨Some (tip of the iceberg) videos
Lipid Energy Model: youtu.be/AkzxESsTJyM?si=dDR1…
OreoVsStatin: youtu.be/L1mMnnyJrgk
3 month ‘update’ youtu.be/oK9sQA6oHd0
41 RCT Meta: youtu.be/FcUUqGJBXFM
ApoB and ACM: youtu.be/sAjDjLJUlQQ
LMHR confusion: youtu.be/4_9UFPopl2g
Not the saturated fat: youtu.be/Ee5A3_WIh4U
How to Lower LDL based on etiology: youtu.be/-HZEjnw4WTs?si=Oibx…
Convo with @Physionic_PhD: youtu.be/08IFnuWiltA?si=qpE2…
Metabolic Link @DominicDAgosti2: youtu.be/AVL-xrhHnWI?si=N78h…
🚨Publications. #4 is Meta of RCTs. #8 is #LEM.
(1) Budoff M, Manubolu VS, Kinninger A, Norwitz NG, Feldman D, Wood TR, Cury R, Feldman T, Fialkow J, Nasir K. Carbohydrate restriction-induced elecations in LDL-choelsterol and athetosclerosis: The KETO trial. Metabolism2024. doi: 10.1016/j.metabol.2024.155854.
(2) Javier DA, Manubolu VS, Kinninger A, Norwitz NG, Aldana JB, Ghanem A, Ahmad K, Vicuna WD, Hamidi H, Bagheri M, Villanueva B, Flores F, Hamal S, Feldman D, Budoff, MJ. The impact of carbohydrate restriction-induced elevations in LDL cholesterol on progression of coronary atherosclerosis: the ketogenic diet trial study design. Coronary Artery Disease 2024; doi: 10.1097/MCA. 0000000000001395
(3) Norwitz NG, Cromwell WC @Lipoprotein. Oreo cookie treatment lowers LDL cholesterol more than high-intensity statin therapy in a lean mass hyper-responder on a ketogenic diet: A curious crossover experiment. Metabolites. 2024; doi: 10.3390/metabo14010073
*Altmetric 1980 (top 0.02% of all >25M papers ever tracked)
(4) Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009
*In a meta-analysis of 41 RCTs, published in a top nutritional journal, we show that BMI is a major source of heterogeneity in LDL cholesterol response to carbohydrate restriction, far more so than saturated fat.
(5) Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Front Endocrinol 2023; 14:1-7. doi: 10.3389/fendo.2023.1326768
(6) Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. J Clin Lipidol 2022; 16:765-768. doi: 10.1016/j.jacl.2022. 10.010
(7) Feldman D, Huggins S, Norwitz NG. Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower LDL cholesterol: the cholesterol drop experiment. Curr Opin Endocrinol Diabetes Obes 2022; 29:434-439. doi: 10.1097/MED.0000000000000762
(8) Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites 2022; 12:460. doi: 10.3390/metabo12050460
(9) Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Curr Dev Nutr 2021; 6:nzab144. doi: 10.1093/cdn/nzab144
(10) Norwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Front Endocrinol 2022; 13:830325. doi: 10.3389/fendo.2022.830325
@realDaveFeldman @AdrianSotoMota
"After a mean duration of 4.7 years of carbohydrate restriction-induced elevations in #LDL-cholesterol [mean 272 mg/dl, max 591 mg/dl], a metabolically healthy cohort of subjects on a ketogenic diet [#LMHR] did not have greater atherosclerotic burden than participants from a population based cohort with similar risk profiles but markedly lower [123 mg/dl] LDL-C."
And there was NO association was observed between LDL-C and Total Plaque Score
Link: sciencedirect.com/science/ar…
These data are PRELIMINARY... However, they should provoke an important conversation that NEEDS to happen.
Let's (all) be humble with respect to (1) the vigor/confidence of our conclusions (2) what we know, and what we don't, with respect to human physiology and lipid dynamics (and risk) in a new/understudied metabolic CONTEXT.
That said, we can separate academic questions from individual clinical management. Better safe than sorry. But each n = 1 is unique and should be treated as such.
#StayCurious. #LMHR #LEM
For the graphic, I've modified to make it a bit easier to understand:
- The X-axis represents study participants such that each column is one participant. They are ordered in ascending total plaque score (TPS), as measured by CCTA. No yellow column at a given point on the X-axis means a TPS = 0.
- The LMHR/Keto group is on the left and comparison/MiHeart group is on the right.
- There as 2 y-axes: The one on the left is LDL-C in mg/dl, with the jagged line being the LDL-C for each participant (really, should be dot plot since they are separate participants). Purple for LMHR/keto and Green for Miami heart. The Red, here, is the plaque score.
Some select (non-comprehensive) prior publications
- Norwitz NG, Cromwell WC. Oreo cookie treatment lowers LDL cholesterol more than high-intensity statin therapy in a lean mass hyper-responder on a ketogenic diet: A curious crossover experiment. Metabolites. 2024; doi: 10.3390/metabo14010073
- Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009
- Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Front Endocrinol 2023; 14:1-7. doi: 10.3389/fendo.2023.1326768
- Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. J Clin Lipidol 2022; 16:765-768. doi: 10.1016/j.jacl.2022. 10.010
- Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites 2022; 12:460. doi: 10.3390/metabo12050460
- Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Curr Dev Nutr 2021; 6:nzab144. doi: 10.1093/cdn/nzab144
@realDaveFeldman @AdrianSotoMota @I_mitochondria @davidludwigmd @DoctorTro @MichaelMindrum @DominicDAgosti2 @janellison @khurramn1 @Drlipid
As usual: @realDaveFeldman @AdrianSotoMota and I are generally happy to discuss these data openly, their caveats, and past and ongoing projects, with those willing to engage genuinely.
Beth Zupec-KANIA, RDN, CD retweeted
New study of a ketogenic diet in Parkinson's:
tandfonline.com/doi/full/10.…
Beth Zupec-KANIA, RDN, CD retweeted
Dr. Julie Milder from @BaszuckiGroup shares details on the exploding science of metabolic psychiatry. Thirteen trials around the world will help determine who is likely to benefit from ketogenic therapy, paving the way for better care for mental illness.
youtu.be/jheq0n0_oT8
Beth Zupec-KANIA, RDN, CD retweeted
A recent article in @NEJM suggests that GLP-1s like Ozempic reduce the risk of cardiovascular events, such as heart attacks. But does this overlook the role of improved metabolic health?
Hear more from board-certified cardiologist @bschermd: youtu.be/401DxUDy1iU
Beth Zupec-KANIA, RDN, CD retweeted
Is it time to add a dietary intervention that benefits both mental and metabolic health to the treatment menu in psychiatry?
bit.ly/4dUd18E
Explore the growing evidence supporting ketogenic therapy for serious mental illness in this article by @BaszuckiGroup's Science Program Officer, @burcin_ikiz, and Managing Director of Neuroscience, @KirkNylen.
Read more in @PsychToday: bit.ly/4dUd18E
Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bip... sciencedirect.com/science/ar…
Beth Zupec-KANIA, RDN, CD retweeted
This is why insulin and c-peptide should be pulled at EVERY yearly physical.
This individuals blood glucose and A1C are completely normal.
Insulin is high and c-peptide are high. 🚩
A uninformed doctor would’ve sent this client on their merry way heading towards problems.
Beth Zupec-KANIA, RDN, CD retweeted
Given that most Americans have at least one diet-related chronic disease, it's time for the Dietary Guidelines for Americans to include low-carb diets, which are a powerful tool to address #metabolichealth.
Learn more from experts in the field: bit.ly/3wOT8yq
Beth Zupec-KANIA, RDN, CD retweeted
Thanks, again, to @BaszuckiMatt, @janellison, and @DavidBaszucki for sharing your story of hope, healing, and recovery from treatment-resistant bipolar disorder!
There is scientific evidence that the keto can help Type 2 diabetes and epilepsy. Now, some doctors suggest it can even be used as a tool to treat mental health. @tvkatesnow reports.
You are a beacon of light to people who are struggling and seeking solutions to metabolic dysfunction.
Can healing metabolic dysfunction reduce or eliminate the most serious symptoms of #MentalIllness?
Mania that leads to psychosis (losing touch with reality) is one of the most dangerous symptoms of mental illness, often leading to hospitalization and lifelong treatment with powerfully sedating neuroleptic (anti-psychotic) medications.
But some people are finding that metabolic strategies like #KetogenicTherapy can protect against mania and psychosis, and research trials are underway.
In her latest blog post, Hannah Warren shares her story of descending into mania and believing water skiers were angels, as well as how she recovered and continues to stay well even without medication.
Read @Radiantbeasting's blog here:
Angels on Water Skis: My Descent into Mania & How I Regained & Maintain My Sanity
In the summer of 2021, while listening to podcasts about spiritual transformation, I spent countless hours painting my kitchen cabinets teal and stenciling them with ornate golden designs. I had been off of antipsychotic medication for one year. Life felt magical, yet I knew something wasn’t right because I had too much energy. I rarely sat down. I always had to be busy with a task, like cleaning or home renovations. I never got a full night of sleep. I began to question my mental stability, and worried that, once again, I was teetering on the edge of another world.
One afternoon, I went for a jog to burn off the excess energy I felt invading my cells. When I hit the three-mile mark on my riverside run, I didn’t turn back home as usual. Instead, I crossed over a bridge to a path on the other side of the river that winds between small forested limestone cliffs and an abandoned railroad track. I didn’t quite realize it, but I was also crossing into an alternate reality.
On the path, I made eye contact with an emaciated man on a bicycle who came to a sudden stop beside me. “I’m an artist,” he said, pulling a red rock from his pocket. I stared at it, transfixed by a gold geometric symbol that appeared magically lenticular. “I paint rocks and hide them along the river path for children to find. The rocks bring God to the Earth,” he said. “To find him, just look up.” He pointed to the sky. His large, frenetic eyes were a disorienting shade of hazel, muddy and almost colorless, until I looked closely and discovered vibrant splinters of green and blue.
“I see him,” I said.
I was no longer teetering on the edge of delirium. I had descended, and I no longer recognized my illness. Being suddenly swallowed by psychosis is like falling asleep while awake. It’s navigating the world like a sleepwalker, oblivious to dangers. It’s the opposite of a lucid dream, one where you become aware you are dreaming. In a psychotic state, reality doesn’t return when you open your eyes.
The rock painter, one of God’s trusted coworkers, invited me to join him at a free water ski gymnastics show.
“Yes!” I said enthusiastically.
We sat on bleachers in the park and watched teenagers maneuvering on water skis, their bodies gracefully flipping about, periodically suspended in gravity-defying positions. The orange evening sun glistened off the water and the sequins on their costumes, and illuminated their faces with glints of light. I was sure they were transcendent beings, angels granted special permission to visit Earth. They were there to usher me into the better universe I could feel permeating the air around me.
A Third Hospitalization, Medicated for Manic Psychosis
I was admiring the unearthly beauty of the riverfront park when my dad called. I felt like I could feel every single particle around me vibrating, and see them radiating color. “I am in a beautiful impressionist painting that has come alive, surrounded by angels,” I told him.
My dad, a retired newspaperman, rushed to the picnic table where I sat looking up at the trees as the sun set. I was discussing holy water with the artist, who my dad later told me reeked of alcohol. “I’m taking you to the hospital,” he said, running his hand through his thick gray hair. He was wearing a plaid button-down shirt and looked worried. I agreed to go to the hospital, believing I would soon be untethered, and granted permission to move freely between Heaven and Earth.
At the hospital, I was put back on Olanzapine, the antipsychotic I had been taking for most of the last ten years. After my first psychotic episode in 2012, I took it for six months before I tried going off. During that half year, I had rapidly put on more than seventy pounds and I hated the way I felt on the medication. I’d experienced suicidal depression, blunted emotions, and impaired cognition. I felt sedated all the time. When I stopped taking the medication, I worked hard to lose the weight I had gained, and started to feel better. But, within a year, I was back in the clutches of mania. That’s when a doctor told me I had bipolar 1 disorder, a chronic, lifelong illness. I needed to stay on medication indefinitely, and endure the debilitating side effects, if I wanted to be a functional, responsible human being.
For seven years, I was in mourning and felt like a part of me had died. I forced myself to accept that my life would never again be like it was prior to my diagnosis. I would need to adapt to a new normal. I would be sedated and sluggish, but sane. I lived that way, until I couldn’t bear it any longer. I didn’t want to be drugged and have poor physical health. I didn’t want to sacrifice all the things I enjoyed about life in exchange for mental stability. It was a cruel, unbearable trade-off, and I felt that my best years were passing me by. The onset of the pandemic in 2020 reinforced the uncertainty and transience of life and after many years of stability, I decided to experiment going off medication again.
In the time leading up to my 2021 hospitalization, I had begun to improve my life with holistic life-enhancing practices, which made stopping medication seem justifiable. I had given up drinking, and began meditating, journaling and exercising regularly. I routinely practiced intermittent and extended fasting. I loved the feeling I got while fasting, and felt compelled to do it frequently. I had lost weight, my energy levels, focus, creativity, and quality of thought had started to return. I was beginning to feel like myself again for the first time in years. I was even starting to believe I had a bright future, free of mania and psychosis, where my perception would no longer become disjointed from reality. But seeing water skiing teenage angels made it clear that everything I was doing to be stable wasn’t enough.
A Light in the Darkness: The Brain Energy Theory Gave Me Hope
When I got out of the hospital, reality and suicidal depression set in. I knew what lay ahead of me in a life on Olanzapine: weight gain, suicidality, blunted emotions, and impaired cognition. One of my first rational thoughts as the last bits of delusional thinking disintegrated was, “Can I really survive this again?”. I wasn’t sure, but I found one ray of hope in an idea that occurred to me: maybe, just maybe, there were effective alternative treatment options that I was unaware of.
I began searching for non-pharmacologic treatments online and eventually discovered the work of Harvard psychiatrist Dr. @ChrisPalmerMD, author of Brain Energy, which ultimately transformed my life and restored my health. Palmer’s brain energy theory posits that mental illness, including my bipolar 1 disorder, is caused by neurometabolic dysfunction, and that the root cause–damaged mitochondria–can be treated with metabolic therapies. It sounded too good to be true.
But Dr. Palmer made a convincing argument, backed up by decades of scientific evidence. He also shared compelling anecdotes of patients on ketogenic diets who were able to go completely off medication, or drastically lower doses and lessen side effects. I was at a breaking point, desperate enough to consider choosing periodic mania and psychosis over weight gain, ill physical health and sedation. There was no reason I shouldn’t try this diet.
On a ketogenic diet, the brain uses ketones, rather than glucose, as fuel. Being in ketosis creates an ongoing state of cellular repair, correcting mitochondrial dysfunction through mitophagy (clearing out damaged mitochondria) and mitochondrial biogenesis (generating new, healthy mitochondria). I learned this form of treatment had the potential to help me manage my symptoms without medication, and even to eventually put my illness into complete remission. In addition to fasting, other things I had been doing leading up to this discovery, including exercise, meditation, and giving up alcohol, it turns out, were also metabolic therapies. I hadn’t realized it, but I had already started metabolic treatments.
My last psychotic episode was the least severe of the three I’ve had, which is atypical, and may indicate that I had already started healing through metabolic interventions. When I added ketogenic therapy, I discovered a skeleton key, a treatment powerful enough to fully restore my physical and mental health and completely protect me from mania. It has unlocked a life of happiness.
I have now been using metabolic therapies for more than two and a half years as my sole form of treatment for neurometabolic dysfunction–what I formerly referred to as Bipolar I. Not only have I never needed to be hospitalized, I have not even had any worrisome symptoms. My world today shines more brilliantly than the most vivid colors of my past psychosis, illuminating a life filled with clarity, serenity, and boundless potential.



















