Assistant Research Scientist @Purdue University My research projects: Protein structure modeling, prediction, Protein structure Modeling from cryoEM data.
West Lafayette, IN
Joined December 2018
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Very excited to share our new paper DAQ-score, just published in @naturemethods .
Our deep learning method can estimate the local quality of the protein structure model from cryo-EM data.
DAQ is available on Google Colab:
bit.ly/daq-score
Paper:
lnkd.in/eTvJfSvH
Genki Terashi retweeted
New preprint by Kai Ling et al.! Distance-AF Multimer uses user-defined residue-pair distance constraints to guide AlphaFold-Multimer predictions, without retraining.
From dimers, peptides, to larger assemblies, it helps improve protein complex models.
biorxiv.org/content/10.64898…
FlashVESPER is now available as a UCSF ChimeraX plugin!
Up to 100× faster cryo-EM map alignment and model fitting with NVIDIA GPUs!
Map-to-map and map-to-model fitting in seconds—even on a laptop!
Plugin: cxtoolshed.rbvi.ucsf.edu/app…
Original VESPER paper: nature.com/articles/s41467-0…
Genki Terashi retweeted
The August update of DAQ-Score DB! It includes Cryo-EM protein model quality evaluations for 283,198 proteins. Figure is an example of a model with seq shifting error.
daqdb.kiharalab.org/
DAQ is easy to compute for str validation for your paper: em.kiharalab.org/algorithm/d…
Genki Terashi retweeted
We posted a new preprint, Prot-LAMBDA.
Unlike most protein language models, it is a pLM with an explicit encoding of protein structures. Strong performance in structure-related tasks including str prediction. biorxiv.org/content/10.64898…
Please stop by my poster at M&M2026!
(227) DAQplugin: AI-Based Interactive Residue-Wise Validation of Protein Models for Cryo-EM Maps
I will show how real-time AI can help identify modeling errors.
Wed, Aug 5, 3:00–5:30 PM
cdmcd.co/nR79mD
Genki Terashi retweeted
New article "Comp. approaches for protein complex modeling for intermediate res. cryo-EM maps" in Progress in Mol Biol & Translational Sci, by Joon Hong Park, @GTerashi, @d_kihara.
Introduces how to use DiffModeler and DMcloud in em.kiharalab.org
pubmed.ncbi.nlm.nih.gov/4246…
Genki Terashi retweeted
In May (5/6 2026) we gave a webinar introducing our EM web server. The recording is now available!
Highlighted 2 recent additions:
• DAQplugin: On-the-fly structure validation for ChimeraX
• CryoZeta: A heterogeneous str modeling for proteins and DNA/RNA
youtube.com/watch?v=AeynIBm1…
Our EM server Webinar recording is now available on YouTube!
I presented,
CryoZeta : Our new framework for cryo-EM structure modeling
DAQplugin : ChimeraX plugin for visualizing and analyzing DAQ scores for model quality assessment
youtube.com/watch?v=AeynIBm1…
Another new preprint of DMcloud, our cryo-EM modeling method for medium- to low-resolution maps. DMcloud uses local model fitting to place compatible protein or DNA/RNA models into enhanced EM maps. biorxiv.org/content/10.64898…
Our recent preprint introduces DAQplugin, a ChimeraX plugin for interactive residue-wise validation of cryo-EM protein models. DAQplugin brings DAQ scoring directly into model inspection on your laptop. biorxiv.org/content/10.64898…
Genki Terashi retweeted
We will host a ~30 min webinar introducing EM-server for cryo-EM structure modeling on May 6 (Wed) 12:30pm (Eastern Time). Will introduce DAQ-Score plugin & CryoZeta.
EM-Server: em.kiharalab.org/
Registration link: kiharalab-events.vercel.app/
Hope to see you there!
Genki Terashi retweeted
うちのラボで作成、管理している電顕のための生体高分子のモデリングツールのウェブサイト、EM-Serverのウェビナーを行います。最近のツール２点を中心にお話します。
日本時間だと深夜１時半ですが、３０分と短いので遅くまで起きてる方は参加をお待ちしております。
kiharalab-events.vercel.app/
We will host a ~30 min webinar introducing EM-server for cryo-EM structure modeling on May 6 (Wed) 12:30pm (Eastern Time). Will introduce DAQ-Score plugin & CryoZeta.
EM-Server: em.kiharalab.org/
Registration link: kiharalab-events.vercel.app/
Hope to see you there!
Genki Terashi retweeted
New collaboration paper with Bou-Abdallah lab just released! Multivalent recognition of ferritin by full-length NCOA4 enables robust ferritinophagy, Srivastava, @GTerashi et al., Protein Science
onlinelibrary.wiley.com/doi/…
Genki Terashi retweeted
We have a postdoc opening. Please check
careers.iscb.org/jobs/view/9…
Our new book chapter has just been published!
In this chapter, we introduce our recent work in computational structural biology and practical applications of our tools available on em.kihara.org.
You can read the chapter here:
authors.elsevier.com/a/1ms5k…
Genki Terashi retweeted
We’ve rebuilt our Protein Function Prediction server!
New:
• Domain-PFP: self-supervised, domain-aware function prediction
• GO2Sum: converts GO terms into UniProt-style functional summaries
All methods (PFP, Phylo-PFP, ESG) now in one interface.
kiharalab.org/pfp
Genki Terashi retweeted
Intellicule is hiring a part-time Software Engineer to advance our computational biology tools for protein design, nanobody engineering, and Cryo electron microscopy (cryo-EM) based drug discovery.
Submit resume and cover letter to [email protected]
Genki Terashi retweeted
New collaboration paper with the Bou-Abdallah lab at SUNY Potsdam: "Ferritin iron uptake and oxidation are dynamically modulated by nucleotide phosphate architecture via electrostatic gating", International Journal of Biological Macromolecules. sciencedirect.com/science/ar…
Genki Terashi retweeted
Accurate Macromolecular Complex Modeling for Cryo-EM with CryoZeta biorxiv.org/content/10.64898… #biorxiv_bioinfo
Genki Terashi retweeted
🚀 First DAQ-Score DB update of 2026 is live!
Cryo-EM protein model quality evaluations now cover 266,577 protein chains.
🔗 daqdb.kiharalab.org
🏁Check out also our New ChimeraX plugin! It lets you check DAQ scores during modeling!
cxtoolshed.rbvi.ucsf.edu/app…
