Integrative #Genetics, #Genomics, and #Bioinformatics, with basic and clinical #Neuroscience, of neurologic and psychiatric disease. Tweets from lab members.
UCLA
Joined September 2019
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Thanks to Pico Caroni, @AllenInstitute and other organizers/sponsors for a great inaugural conference on the Neurobiology of Mental health. Fantastic program and setting in Thun, Switzerland. @LakeConferences
Geschwind Lab @ UCLA retweeted
New in @ScienceMagazine: Our paper mapping gene/isoform/splicing regulation at pop-scale during human #neurodevelopment.
Major developmental shifts in #genetic reg.,
New colocalized risk genes at ~60% of #psych #GWAS loci. #PsychENCODE24
science.org/doi/10.1126/scie…
Geschwind Lab @ UCLA retweeted
Characterizing >100,000 sequences in primary neurons and organoids and deep learning to decode regulatory activity. Amazing work from @Chengyu_Deng_, @seawhalen, Katie Pollard, @LabNowakowski and others as part of #PsychENCODE in @ScienceMagazine.
science.org/doi/10.1126/scie…
This represents the culmination of years of work by the @NIMHgov #PsychENCODE consortium! furthering our understanding into the genetic and molecular mechanisms of neuropsychiatric conditions🧠🧬 Read more in @ScienceMagazine: science.org/collections/psyc… #Genomics #Neuroscience
Proud of our UCLA CART colleagues!
A study co-led by researchers at UCLA CART has found distinct brain connectivity patterns in six-week-old infants at risk for developing autism spectrum disorder (ASD). uclahealth.org/news/release/…
Excited to announce our new pivotal work on autism in the latest #PsychENCODE collection, science.org/doi/10.1126/scie…
see also @MarkGerstein, @mikejg84 #autism #genomics
Our latest publication led by Yonatan Cooper identifying new dementia risk genes using MPRAs to screen noncoding GWAS variants of neurodegenerative disorders w/ functional validation in neurons and microglia @MartinUCSF @srikosuri @giovannicoppoIa
science.org/doi/10.1126/scie…
Our latest publication from Chris Hartl characterizing brain-wide and brain region-specific gene co-expression, providing a framework to contextualize neuropsychiatric genetic risk, supporting polygenic models of disease
go.nature.com/3iBPvkL @kasper_lage @alexisjbatte
Dr. Geschwind recently served as a witness in a congressional hearing coordinated by Congresswoman Karen Bass. His testimony focused on introducing Autism Spectrum Disorder. Take a few minutes to listen to Dr. Geschwind's statement: youtu.be/V7qgpVf-_EI?t=887.
Geschwind Lab @ UCLA retweeted
Announcing the 1st Annual Conference on Precision Psychiatry! Grateful to our amazing speakers @NIMHDirector @AllofUsCEO @WrayNaomi @royperlis @GregSimonKPWHRI @clesemartin @CRodriguezMDPhD @GeschwindLab
@tanzeemc @Stanford_PMHW + more!
RT & Register here:
mghcme.org/precision-psychia…
Geschwind Lab @ UCLA retweeted
Our paper looking at the long-term maturation of cortical organoids is out! rdcu.be/cfDQt #organoids #brainorganoids
TL;DR - human cortical organoids start to resemble postnatal cortical development after 250-300 days of culturing
Dr. Geschwind leads IPH and played a major role in securing this gift. We are very thankful to our donors, Dr. Allen and Charlotte Ginsburg!
Read more: newsroom.ucla.edu/releases/u…
Thrilled to share that UCLA received a $29M gift to establish a center within the Institute for Precision Health (IPH). which will enable Scientists & physicians to work side by side to examine the role of genetics in disease and develop therapies that improve patients’ lives.
Geschwind Lab @ UCLA retweeted
Don't forget to join us for the Spring 2021 Seminar Series today at noon! Speaker is Daniel Geschwind, MD, PhD, from @UCLA. Here's the Zoom webinar link: wustl-hipaa.zoom.us/j/925888… #WashUGen @GeschwindLab
Geschwind Lab @ UCLA retweeted
@UCLAHealth @GeschwindLab Making Sense of Sequencing: Exome Sequencing Analysis and What's Next.
Listen to it here: bit.ly/2XIgOA4
Episode also available on @ApplePodcasts: apple.co/30PvU9C
#geneexpression #genetics #genomics #sequencing #Findinggeniuspodcast
Geschwind Lab @ UCLA retweeted
Now out! From @GeschwindLab @UCLA : Abnormal social and repetitive behaviors and elevated striatal dopamine, a molecular hallmark of human psychosis, in a Maternal Immune activation non-human primate model biologicalpsychiatryjournal.…
Geschwind Lab @ UCLA retweeted
Proud and excited to share our work on multi-omic integration in Autism! 1/4
nature.com/articles/s41467-0…
Geschwind Lab @ UCLA retweeted
My commentary on integrative genomics for the interpretation of genetic loci implicated in neurodevelopmental disorders is out today in @BiologicalPsyc1!! I had a lot of fun writing this and reflecting on all that I’ve learned from the great @GeschwindLab authors.elsevier.com/a/1bdLV…