@FdAdF66

Principal Investigator @IFOMresearch and IGM-CNR. Begging to differ.

 Milan, Lombardy
ifom.eu/en/cancer-research/programs/dna-damage-response-cellular-senescence.php
Joined February 2011
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Can an antisense oligonucleotide (ASO) targeting an RNA that is neither coding nor encoded by a gene extend the lifespan of a mammal? nature.com/articles/s41467-0… #DDRNA #ncRNA #telomere #aging #ASO
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🚨 Can we kill a cell by targeting DNA that does nothing? 🧬 Our study shows Cas9 can selectively kill cells carrying a non-functional target sequence, sparing cells without it. Weaponizing CRISPR/Cas9 for selective elimination of cells with an abe… sciencedirect.com/science/ar…
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🚨 Can broken DNA generate a new protein? Our study independently confirms that DSBs trigger transcription from the break—and shows, for the first time, that the resulting RNA can be translated. Could this generate neoantigens after radio/chemotherapy? nature.com/articles/s42003-0…

Site-specific DNA double-strand break induces local transcription in cis and protein expression

Communications Biology - DNA double-strand breaks function as promoter-like elements that drive transcription and protein synthesis of polyadenylated RNAs from otherwise silent DNA regions.

nature.com
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#IPF has no cure. Median survival: 4 years. Lung transplant is the only real option. Our new paper shows this might be about to change. 🧵
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Together: #tASOs (the molecules we use) look like a real shot at treating #Telomere Biology Disorders (#TBD) broadly — IPF, bone marrow failure, and more.
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Disclosure: I co-founded TAG Therapeutics, exploring clinical development of this approach — this study was independent academic work. 📄 IPF paper: link.springer.com/article/10…

The telomeric DNA damage response as a therapeutic target in idiopathic pulmonary fibrosis

EMBO Molecular Medicine - Telomere dysfunction and the telomeric DNA damage response (tDDR) activation correlate with aging and age-related diseases, including idiopathic pulmonary fibrosis (IPF)....

link.springer.com
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Fabrizio d'Adda di Fagagna retweeted
Nature Aging@NatureAgingJun 30
Online now!✨Oppezzo et al therapeutically block telomeric DNA damage signalling to restore hematopoietic function in telomerase-deficient and aged mice, while reducing senescence and inflammation @FdAdF66 @IFOMresearch nature.com/articles/s43587-0…

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by...

Nature Aging - Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in...

nature.com
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1/ What if some of the consequences of #aging are not caused by damage itself, but by the alarm signals our cells generate in response to that #damage? Today, we publish a study in @NatureAging addressing this question. nature.com/articles/s43587-0…

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by...

Nature Aging - Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in...

nature.com
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8/ This journey is now continuing beyond academia. tag-therapeutics.com/ is advancing this approach toward clinical translation.

TAG Therapeutics | Teloblock

TAG Therapeutics develops precision medicine approaches for telomere pathologies and aging-related diseases, such as Idiopathic Pulmonary Fibrosis and Short Telomere Syndromes

tag-therapeutics.com
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Deep gratitude to @Fondaz_Telethon , @ERC_Research, @IFOMresearch, @CNRsocial_, @AGEIT_PE8 and all who supported this work.
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Happy to share our deep characterization of #LLPS events modulating the DNA damage response (#DDR) through #53BP1 condensation promoted by #dincRNA: biorxiv.org/content/10.64898…
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