physician-scientist, author of SUPER AGERS https://xitter.cf/t.co/ZEdooyyJpP and Ground Truths: https://xitter.cf/t.co/YhatcBT0hA
La Jolla, CA
Joined November 2009
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A new cover for SUPER AGERS after making the NYT bestseller list. Thanks to you for making it the #1 ranked new non-fiction book on Amazon.
amazon.com/gp/new-releases/b…
ClinicalAge, an AI-derived metric from longitudinal electronic health records, varies widely from an individual's chronological age. And it's correlated with risk of many diseases and cancers, as shown below, from 2 huge cohorts @uk_biobank @LancetDigitalH
thelancet.com/journals/landi…
Mapping a path to prevent breast cancer
@ScienceMagazine
Ductal carcinoma in situ (DCIS) is common and can be a precursor to invasive cancer. Elegant single cell and spatial omics work here tells us how DCIS progresses, earlier than previously anticipated, and lays a foundation for prevention
science.org/doi/10.1126/scie…
The critical role the blood brain barrier (BBB) plays in the Alzheimer's disease model, and how to modulate the BBB "transportome" and rescue brain astrocytes @CellCellPress
cell.com/cell/fulltext/S0092…
“Alzheimer’s disease may not start entirely inside the brain; It may start when the brain’s supply line from the body is severed." @ScienceMagazine @GladstoneInst
Good summary @TheEconomist, gift link
economist.com/science-and-te…
How multimodal AI, combined with blood test omics via "liquid biopsies," will transform cancer monitoring and enable earliest detection.
open-access @CellCellPress
cell.com/cell/fulltext/S0092…
This is applicable on a daily basis.
The irony of AI's remarkable predictive power and its unpredictability
New cover @TheEconomist
Everyone has at least one DNA variant that affects their response to a medication. And almost no one knows that or the variant(s) they carry. @AllofUsResearch
science.org/doi/10.1126/scit… @ScienceTM
Trying to buy healthspan with lots of money.
From gene therapy, to hyperbaric chambers, multiple "longevity doctors" on speed dial, to an abundance of unproven biohacking tactics
gift link, by @GunjanJS
wsj.com/health/wellness/meet…
Moving on to preventing cancer with vaccines
With today's @NEJM publication of the melanoma treatment vaccine success nejm.org/doi/full/10.1056/NE…
The editorial notes the remarkable potential for vaccines to prevent cancer:
nejm.org/doi/full/10.1056/NE…
"a vaccine against 25 recurrent mutational hotspots
in genes such as KRAS, BRAF, and PIK3CA could
target mutations found in more than 70% of
colorectal, pancreatic, uterine, and melanoma
skin cancers."
And @moderna_tx declares it's the future with an ongoing trial to prevent Lynch syndrome and more to come
ft.com/content/30b27a58-35bf…,
Getting it wrong for many decades.
Since the 1950's, pacemaker leads have been placed in the right ventricle. A new randomized trial challenging that dogma found marked superiority of outcomes for pacing from the left bundle branch. nejm.org/doi/full/10.1056/NE…
A study on accelerated aging with chemotherapy for breast cancer
More aggressive chemo, improved breast cancer survival but a tradeoff of accelerated biological aging and increased risk of non-breast cancer mortality
jamanetwork.com/journals/jam…
The obesity adverse outcome story.
BMI is a poor and misleading way to quantify obesity
When the CAD-obesity definition is used, we see the increased risk of all-cause mortality (top graphs) and lesser risk for preclinical obesity (lower graphs)
@Nature
nature.com/articles/s41586-0…
It's hard to beat @emollick for an up-to-date, independent assessment of AI, no less where we're headed. His new book is CO-EXISTENCE. We discussed that and a lot more in the new Ground Truths today
AI could reboot how science is done
Check out @emollick's energy!
erictopol.substack.com/p/eth…
Eric Topol retweeted
Great discussion! Can’t do much better than this @emollick interview w @EricTopol to get up to speed on AI in general, and potential implications for life sciences, healthcare in particular.
Also: appreciate that Ethan talks as fast and as intensely as my kids say I do….
It's hard to beat @emollick for an up-to-date, independent assessment of AI, no less where we're headed. His new book is CO-EXISTENCE. We discussed that and a lot more in the new Ground Truths today
"Simply Aging"
A brilliant perspective on the complex (anything but simple) biology of human aging, by @VadimGladyshev @gladyshev_lab open-access @PNASNews pnas.org/doi/10.1073/pnas.26…
Setting an unattainable objective. I wish it would come true, but curing all these diseases in the next 10 years is impossible.
And I'm very optimistic about the impact of AI for improving health.
The impressive impact of strength training for preserving muscle mass while taking a GLP-1 drug for obesity, as seen in randomized trial @NatureMedicine
T=tirzepatide alone (Zepbound), T + REx=drug with resistance exercise
nature.com/articles/s41591-0…
