@_hubmap

an NIH-funded consortium of scientists developing an open, global framework for comprehensively mapping the human body at a cellular resolution.

hubmapconsortium.org
Joined March 2019
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241Media
Human BioMolecular Atlas Program (HuBMAP) retweeted
Giovanni D'Angelo
@Gio_Dangel0Sep 23
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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Not to be vein, but from the apex of our hearts, we think this Xenium image of the right ventricle from Chenchen Zhu in Mike Snyder's lab @Stanford will ventricle your fancy!
Xenium is an assay that tells researchers where in a tissue particular genes are being expressed and making a kind of map out of the results. You can see that Chenchen really put his heart in this one! White - mesenchymal, green - endothelial, magenta - myeloid, blue - nerve, yellow - muscle, red - epithelial, teal - lymphoid, gray - other

ALT Xenium is an assay that tells researchers where in a tissue particular genes are being expressed and making a kind of map out of the results. You can see that Chenchen really put his heart in this one! White - mesenchymal, green - endothelial, magenta - myeloid, blue - nerve, yellow - muscle, red - epithelial, teal - lymphoid, gray - other

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DYK that lymph nodes fight infection by housing white blood cells that destroy bacteria&viruses? This nodeworthy CODEX image of a lymph node TMA was made by Negin Farzad in Rong Fan’s lab at @Yale. Much like a lymph node that just spotted a foreign body we’re swelling with pride
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I spleen, you spleen, we all spleen for this spleen-did Xenium image of a human spleen, the organ that filters blood, produces immune cells, and helps your body fight infections made by HuBMAP researchers Drs. Gloria Pryhuber (URMC) and Chenchen Zhu (Stanford).
Xenium technology shows researchers where specific RNAs reside in an organ, giving them an idea about how the RNAs relate to each other in the space of the organ. It’s spleen-tastic! White – mesenchymal cells, green – endothelial cells, magenta – myeloid cells, blue – neurons, yellow – muscle cells, red – epithelial, teal – lymphoid, gray – other

ALT Xenium technology shows researchers where specific RNAs reside in an organ, giving them an idea about how the RNAs relate to each other in the space of the organ. It’s spleen-tastic! White – mesenchymal cells, green – endothelial cells, magenta – myeloid cells, blue – neurons, yellow – muscle cells, red – epithelial, teal – lymphoid, gray – other

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Xenium technology shows researchers where specific RNAs reside in an organ, giving them an idea about how the RNAs relate to each other in the space of the organ. It’s spleen-tastic!
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White – mesenchymal cells, green – endothelial cells, magenta – myeloid cells, blue – neurons, yellow – muscle cells, red – epithelial, teal – lymphoid, gray – other
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The pandemonium of daily life has you insulinely tired? Then pan a shot over to this Xenium image of the thousands of RNAs that reside within the body of the pancreas, made by HuBMAP researcher Chenchen Zhu from @Stanford, who is nothing if not pancreas-ionate about his work!
Xenium image of the thousands of RNAs that reside within the body of the pancreas White - mesenchymal cells, green - endothelial cells, magenta- myeloid, blue - nerve cells, yellow - muscle, red - epithelial, teal - lymphoid cells, gray - other

ALT Xenium image of the thousands of RNAs that reside within the body of the pancreas White - mesenchymal cells, green - endothelial cells, magenta- myeloid, blue - nerve cells, yellow - muscle, red - epithelial, teal - lymphoid cells, gray - other

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White - mesenchymal cells, green - endothelial cells, magenta- myeloid, blue - nerve cells, yellow - muscle, red - epithelial, teal - lymphoid cells, gray - other
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Human BioMolecular Atlas Program (HuBMAP) retweeted
NIH
@NIHJun 11
NEWS: NIH research establishes new framework for the role of senescence in aging. Read the full story ➡️ nih.gov/news-events/news-rel…
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Once again, the certified #_HuBMAP air-tists/researchers in Dr. Gloria Pryhuber's lab at @UR_Med hope to take your breath away with this multimodal image of airway epithelium, submucosal gland, and duct from the lung. We hope it respires you to live lung and prosper.
Multimodal image of airway epithelium, submucosal gland, and duct from the lung. Lung - Airway Epithelium and Submucosal Gland and Duct PTPRC - CD45 - Orange - immune cells PECAM1 - CD31 - Green - endothelial cells KRT5 - Yellow - basal epithelial cells ACTA2 - White - smooth muscle cells FOXJ1 - orange in epithelium, motile ciliated cells SCGB3A2 - pink - lung epithelial cells and submucosal glands SFTPB - pulmonary surfactant protein MUC5AC - bright blue - gel-forming glycoprotein in the lungs MUC5B - turquoise - gel-forming mucin protein

ALT Multimodal image of airway epithelium, submucosal gland, and duct from the lung. Lung - Airway Epithelium and Submucosal Gland and Duct PTPRC - CD45 - Orange - immune cells PECAM1 - CD31 - Green - endothelial cells KRT5 - Yellow - basal epithelial cells ACTA2 - White - smooth muscle cells FOXJ1 - orange in epithelium, motile ciliated cells SCGB3A2 - pink - lung epithelial cells and submucosal glands SFTPB - pulmonary surfactant protein MUC5AC - bright blue - gel-forming glycoprotein in the lungs MUC5B - turquoise - gel-forming mucin protein

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Lung - Airway Epithelium and Submucosal Gland and Duct PTPRC - CD45 - Orange - immune cells PECAM1 - CD31 - Green - endothelial cells KRT5 - Yellow - basal epithelial cells ACTA2 - White - smooth muscle cells
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FOXJ1 - orange in epithelium, motile ciliated cells SCGB3A2 - pink - lung epithelial cells and submucosal glands SFTPB - pulmonary surfactant protein MUC5AC - bright blue - gel-forming glycoprotein in the lungs MUC5B - turquoise - gel-forming mucin protein
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Does this CODEX image of an ovary send you ova the moon? This egg-citing image was made by NIH funded #_HuBMAP scientists @UPenn & @LurieChildren's, using antibodies specific to cell types found in the ovary to show the spatial relationships within. Ova it? Never!!!!
CODEX image of an ovary follicles - red and blue, luteinizing cells - pink, extracellular matrix - purple, green, white, vessels - yellow and orange

ALT CODEX image of an ovary follicles - red and blue, luteinizing cells - pink, extracellular matrix - purple, green, white, vessels - yellow and orange

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follicles - red and blue, luteinizing cells - pink, extracellular matrix - purple, green, white, vessels - yellow and orange
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Not to be an ovary-achiever, but this CODEX image of oocytes in a healthy human ovary made by scientists at @UPenn & @LurieChildren’s is egg-straordinary! Images like this prove researchers aren’t just follicle-ing around! 😉
CODEX image of oocytes in a healthy human ovary. Green – oocytes, Pink – extracellular matrix, Cyan – vessels, Blue and Yellow – epithelial cells Photo credit - UPenn & Lurie Children’s (O’Neill, Kim, Laronda)

ALT CODEX image of oocytes in a healthy human ovary. Green – oocytes, Pink – extracellular matrix, Cyan – vessels, Blue and Yellow – epithelial cells Photo credit - UPenn & Lurie Children’s (O’Neill, Kim, Laronda)

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Photo credit - UPenn & Lurie Children’s (O’Neill, Kim, Laronda)
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Green – oocytes, Pink – extracellular matrix, Cyan – vessels, Blue and Yellow – epithelial cells
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Do you have the intestinal fortitude to check out your viscera? Then follow your gut instincts and digest this CODEX image of a healthy colon from John Hickey when he was at the of the Nolan Lab Stanford. We hope it bowels you over as much as us!
CODEX image of a healthy colon

ALT CODEX image of a healthy colon

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Pi day just passed, so you know what that means! It's time for a slice of kidney pi(e), and that's a renal treat! This CODEX image of a kidney pi slice was made by #hubmap researchers Drs. Tarek Ashkar & Sanjay Jain @wustl, and we're not being irrational!
CODEX image of a kidney pi slice Red - podocytes, green - endothelial cells, yellow - smooth muscle cels and arterioles, cyan - thick ascending limb tubules, blue - proximal tubules, brown - distal convoluted tubules

ALT CODEX image of a kidney pi slice Red - podocytes, green - endothelial cells, yellow - smooth muscle cels and arterioles, cyan - thick ascending limb tubules, blue - proximal tubules, brown - distal convoluted tubules

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Red - podocytes, green - endothelial cells, yellow - smooth muscle cels and arterioles, cyan - thick ascending limb tubules, blue - proximal tubules, brown - distal convoluted tubules
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