We use #SystemsBiology to discover things about cells. @ETH_en
Zurich, Switzerland
Joined April 2021
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We are beyond proud of our newest @NatureMedicine paper! Using pharmacoscopy & in-silico drug MoA discovery, we show that the antidepressant Vortioxietine is effective in #Glioblastoma primary patient material and in mouse models.
bit.ly/GBM_SL
#PersonalizedMedicine
Snijder Lab retweeted
Please welcome HT SpaceM, our new method for high-throughput small-molecule single-cell metabolomics: 👉Delafiori, Shahraz et al, BioRxiv biorxiv.org/content/10.1101/… 🧵👇
Snijder Lab retweeted
A single-cell ex vivo screening of repurposable drugs in #glioblastoma coupled with machine learning show that anti-tumour neuroactive drugs converge on the AP1-BTG pathway and identify the antidepressant vortioxetine as a potential therapeutic agent.
nature.com/articles/s41591-0…
Congrats to @ssoeylee & @to123w for spearheading this work and thanks to all the collaborators from @NeuroOnco_USZ 🥳
Snijder Lab retweeted
Researchers at ETH Zurich have used a drug screening platform they developed to show that an #Antidepressant, currently on the market, kills #Tumour cells in the dreaded #Glioblastoma – at least in the cell-culture dish. brnw.ch/21wMV3Q
Snijder Lab retweeted
We are happy to announce that the PHRT-funded clinical study “RAPID 01”, which includes patients with acute myeloid leukemia (AML) is moving into the next phase: Soon, the first patient will be recruited. Read more about it here: bit.ly/3XLDbnU
Snijder Lab retweeted
This beautiful image illustrates our new paper on 13C-SpaceM, a new method tracing metabolic activity in single cells in @NatMetabolism 😁 First, about the paper nature.com/articles/s42255-0… 📜:
Snijder Lab retweeted
🦓 This week: 'stripy' #Tcells!
A recent @ScienceMagazine article from Dr. Ben Hale and a team in Dr. @BerendSnijder's lab suggests that T cell architecture is a key determinant of TCR signaling & #CellFate.
@SnijderLab
📑: bit.ly/45A25ZR
🎤: bit.ly/3VXX1vr
Snijder Lab retweeted
Researchers identify key differences in inner workings of immune cells: more than half of all killer T cells exhibit nuclear invaginations, or folds in the cell’s nuclear envelope.
brnw.ch/21wKwHr
Snijder Lab retweeted
#Tweetorial for our paper in @ScienceMagazine
It's still largely unknown how naïve T cells decide to become either effector or memory T cells during viral infection. We show that these decisions are built into the cellular architecture of our T cells. 1/9
bit.ly/stripyBH
Snijder Lab retweeted
Looking forward to talking about #StripyTcells and our recent @ScienceMagazine publication with @thalexandrov, his team, and you (if you want)! The talk is public, so feel free to join: embl-org.zoom.us/j/944310426…
Big thanks to Theodore & co. for the invitation!
As an external talk at @alexandrovteam meeting, on Tue 18th at 10:15am CEST, Ben Hale from the @BerendSnijder lab will present on their paper just out in Science science.org/doi/10.1126/scie…
The talk is open to public and everyone is welcome! 🔓 Link to join: embl-org.zoom.us/j/944310426…
#Tweetorial for our paper in @ScienceMagazine
It's still largely unknown how naïve T cells decide to become either effector or memory T cells during viral infection. We show that these decisions are built into the cellular architecture of our T cells. 1/9
bit.ly/stripyBH
Furthermore, ex vivo #SingleCell fate tracking revealed that Tø cells form large colonies of effector-like T cells following activation. By contrast, cells with To architectures were slower to divide and gave rise to memory-like T cells. 8/9
Our findings suggest that #TCellArchitecture is a key determinant of TCR signaling & cell fate. This understanding could help predict & optimize T cell responses for better infection protection & disease treatment. Read the paper for more details!🔬 #Immunotherapy #Immunology 9/9