@sebatlab

From DNA to the brain. Occasionaly fatherhood, cycling, indie rock. No, Dad will not turn his music down.

 La Jolla, CA
sebatlab.org
Joined October 2014
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  • Following2.8K
  • Followers5K
1.7KMedia
I'm pleased to share our latest preprint: Combinatorial effects of gene dosage, polygenic background and environment on complex traits 🧵medrxiv.org/content/10.64898…

Combinatorial effects of gene dosage, polygenic background and environment on complex traits

Complex traits arise from the combined effects of rare and common genetic variation, development and environment, but resolving their joint contributions has been limited by statistical power. Here,...

medrxiv.org
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obviously not old enough
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Honky Chonk Beardonkadonk⁣⁣
A large bear sitting in water fishing for salmon.

ALT A large bear sitting in water fishing for salmon.

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Q: What 2000’s indie rock band predicted the rise of AI coding agents A: “OK Go” okgo.net/

OK Go

OK Go is a band. They like to make stuff.

okgo.net
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Anshul Kundaje@anshulkundajeAug 8
This is great news. What a relief. Judy is an awesome scientist and a great leader. NHGRI is in good hands.
NIH
@NIHAug 7
NEWS: NIH selects Dr. Judy Cho as director of the National Human Genome Research Institute. Read the full story ➡️ bit.ly/3U4Jsvr
Announcing Dr. Judy Cho as NHGRI Director

ALT Announcing Dr. Judy Cho as NHGRI Director

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moose
@mooseincrisisJul 29
i’ve seen a lot of people asking why i attacked this guy. i’d like to apologize… to absolutely nobody. Fuck him.
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Jonathan Sebat retweeted
Adam Auton@adamautonJul 27
23andMe is hiring for 2 amazing roles! - Scientist, ML for Health Risk Prediction: build next-gen health prediction tools integrating genetics. - Scientist, Population Genetics: build state-of-the-art algorithms for genetic relationship & ancestry inference. Links below!
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medrxiv.org/content/10.64898… Check our new @medrxivpreprint on #ASXL3 showing the ASXL neurodevelopmental syndromes may be ASO treatable. With @n_lorem. @arrefoundation @LighthouseLeo @SimonsFdn @CIRMnews
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Jonathan Sebat retweeted
Pitchfork
@pitchforkJul 22
If FIFA's World Cup halftime show proved anything, it’s how disconnected the gatekeepers of entertainment are from common people pitchfork.com/story/the-worl…

The World Cup Halftime Show Was Fake as Hell

Pitchfork made it inside MetLife Stadium to get an IRL look at the first-ever World Cup Halftime Show curated by Chris Martin. Featuring a who’s-who of massive stars totally disconnected from one...

pitchfork.com
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My building has no wifi in the restroom, How am I supposed to do my research?
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Congrats to Olivia, Joe, @n_lorem, and most of all @scn2a families!
Joseph G. Gleeson@jogleeson_ucsdJul 21
Replying to @n_lorem
@n_lorem develops two separate antisense oligonucleotide targeting toxic @SCN2A mutations to achieve meaningful improved lives in #epilepsy. at @RadyGenomics @RushMedical. nature.com/articles/s41591-0…. @EpilepsyFdn @LGS_Foundation.
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I've reached a crossroads in life
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What were the odds on Polymarket that the Muppets would play 7 Nation Army in the #worldcup final?
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Gooooooooaaaaaalllll!
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I have a zoom call at 12. France and Spain are going to have to reschedule
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I love the smell of rodents in the morning. It smells like victory.
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This makes me proud to be an American 🫡
Butthole Surfers@buttholesurfersJul 4
July 4, 1989. National Mall, Washington DC. We have always celebrated this holiday correctly. Happy Fourth 🔥🇺🇸
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This year I fielded alot of questions on the causes of autism. It's good to see that some of it is cutting through the noise.
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But maybe not the last
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Jonathan Sebat retweeted
Buzz Patterson
@BuzzPattersonJun 24
The Tartan Army marching through South Beach. The World Cup this year has been the most cathartic single event in uniting the world. I get it. It’s soccer. But you don’t really have to appreciate the sport to appreciate the impact. Our nation is healing and other countries are helping. I love it. ❤️🇺🇸🏴󠁧󠁢󠁳󠁣󠁴󠁿🔥
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Nuno Carvalho@nunorgcarvalhoMay 28
New [Souaiaia et al. 2026 Nature] paper argues that there is "distinct genetic architecture in the tails of complex traits". Some of my thoughts: I'm not a fan of framing traits as having distinct architectures at the extremes when it's not really what's going on
Fig 1

ALT Fig 1

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