Postdoctoral Researcher at the Machine Learning & Computational Biology Lab @AGKBorgwardt at @ETH Zürich
Basel
Joined August 2020
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Sarah Brüningk retweeted
Interested in ongoing clinical trials in #SpinalCordInjury❓
Check out our @SCITrialsFinder website🖥️:
✅ Trials carefully curated by experienced investigators
✅ Easy to understand trial summaries
✅ Instant notifications about new trials
✅ Seamless contact to trial locations
🚨Looking to participate in #SpinalCordInjury #ClinicalTrials that suit your preferences?
Check out @SciTrialsFinder website that matches people with #SpinalCordInjury and #ClinicalTrials. Read our common language trial summaries to easily locate, understand and participate!
Sarah Brüningk retweeted
Our work on #LongCovid 🩸 is now out in @ScienceMagazine!
We found increased complement activation and markers of thromboinflammation in patients with active Long Covid.
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doi.org/10.1126/science.adg7…
Sarah Brüningk retweeted
Altogether, an overly activated complement system may connect different hypotheses on Long Covid pathomechanisms.
While the results require further validation in larger patient cohorts, they provide a basis for new diagnostic solutions and possibly targeted treatments.
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Sarah Brüningk retweeted
By measuring antibodies against >80’000 viral epitopes we found increased IgG against #herpesviruses in Long Covid patients, particularly against CMV and EBV.
Anti-CMV was associated with markers of antibody-mediated complement activation.
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Sarah Brüningk retweeted
But why is complement activated in the first place?
1) Tissue injury can be caused by, and activate, complement 🔄
2) Cross-talk with a dysregulated coagulation system ↔️
3) Classical activation mediated by antibodies ⬇️
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Sarah Brüningk retweeted
Using #MassSpec, we found increased markers of tissue injury, including red blood cells, platelets, and endothelial cells.
#FlowCytometry paired with #scRNAseq showed increased monocyte-platelet aggregates in Long Covid patients.
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Sarah Brüningk retweeted
Functional assays revealed increased complement activation. Increased C5bC6 serum levels contrasted with the decrease of C7 complexes.
This pattern suggested increased incorporation of terminal complement complexes in cell membranes.
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Sarah Brüningk retweeted
Experimental validation revealed that C7 complexes were decreased in the blood of Long Covid patients. Long Covid patients that had recovered before 6-month follow-up, showed normal levels.
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Sarah Brüningk retweeted
We measured >6’500 proteins in the blood of COVID-19 patients during initial infection and 6 months later, compared to healthy controls.
6 months after infection, one protein stood out: complement C7.
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Sarah Brüningk retweeted
The complement system is part of the innate immune response and is unfortunately often forgotten right after the immunology exam.
Here’s a recap by @Kurz_Gesagt:
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youtu.be/BSypUV6QUNw
Sarah Brüningk retweeted
We are very grateful to all the patients donating blood! Also huge thanks to everybody involved in generating and analyzing all data, including @SBruningk @tebiwankenebi @BrodinPetter @AdrianoAguzzi @chr_messner @noambeckmann1 @kmborgwardt and all members of the Boyman lab.
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Sarah Brüningk retweeted
We review in a new preprint the synergistic combination of knowledge-driven and data-driven modeling in #mathonco with @jmetzcar @MathCancer @Jutzeler_Cathy @SBruningk and thanks also to @HauptSaskia @_Alex_Zeilmann_
arxiv.org/abs/2312.07026
Sarah Brüningk retweeted
Towards personalized therapy in DMG with #ML by @SBruningk Treatment response curves, combining classical mathematical modeling with ML, and interpretability aware model training! @PNOC_kids @act_dmg @PNOCFoundation
Sarah Brüningk retweeted
reComBat: batch-effect removal in large-scale multi-source gene-expression data integration. #BatchEffectRemoval #GeneExpression biorxiv.org/content/10.1101/… @biorxiv_bioinfo
Sarah Brüningk retweeted
Excited to share an impression from our first workshop on social media communication held by @scimadesimple and Julia Ecker from @ETHCHAB!
It was a great experience talking to the students at St.Joseph's Academy! Thanks a lot to @SkypeScientist for this opportunity!
Engineering Students Enjoy Skype with Scientist sjabr.org/student-life/news/…
Sarah Brüningk retweeted
#BRCCH warmly welcomes 5 new research projects! Postdocs, together with established Investigators, will conduct translational and ambitious research in #childhealth. Read about the projects👉brc.ch/early-career-research…
@UniBasel_en @ETH_en @SwissTPH
📷J.Pelikan/SwissTPH
ALT A female researcher looks through the lens of a microscope on the left, a circular icon on the right shows a graphic of a researcher walking up stairs. On top, the text says Postdoctoral Excellence Programme.
Sarah Brüningk retweeted
Our most important #COVID19 work so far: @SBruningk @JulianeKlatt & @MadStange examined determinants of SARS-CoV-2 transmission in a city, which could guide vaccination strategies. Spearheaded by @AppliedMicrobi2, w/ H. Hirsch & @UniSpitalBasel @ETH_BSSE medrxiv.org/content/10.1101/…
Sarah Brüningk retweeted
What impacts transmission within cities? Knowledge can guide vaccine strategies -> high populated and mobile areas, but also people with more severity. Read more here: medrxiv.org/cgi/content/shor…
@MadStange @SBruningk @JulianeKlatt @kmborgwardt @UniBasel_en @UniSpitalBasel @ETH_BSSE