Co-Founder, LinkedIn. Investor. MSFT Board Member. Building an LLM to discover cures for cancer: @manas_co. Most importantly: Proud American.

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Joined October 2006
Today, I launched Manas AI –– a full stack AI company setting out to shift drug discovery from a decade-long process to one that takes a few years; bringing life-saving treatments to patients faster than ever.
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The viral clips of AI job interviews aren’t exactly inspiring, and the experience is unlikely to leave a candidate excited to join the team. But that’s a reason to rethink how we use AI in hiring, not write it off entirely.
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Reid Hoffman retweeted
Exclusive: new startup Scuba launches today with $34M in funding and a mission to build the "context engine" for more effective teamwork using AI tools. I spoke to its ex-Slack founders, Noah Desai Weiss (@noah_weiss) and Dolapo Falola (@dolapo), about their product and work 👀
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Reid Hoffman retweeted
What should the future of personal computing look like? We built it 😈 Introducing Imbue Studio:
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This is great. The communities that will live alongside a data center for decades should decide whether to build one and on what terms. The decision to build or not build belongs to the communities who will bear the costs and share in the benefits, and no one else.
Its a bit under the radar, but @GovernorVA and @GovSherrillNJ are quietly steering Democrats' data center policies back to a sane place: No moratoria Let communities decide No NDAs or subsidies Prioritize local construction jobs open.substack.com/pub/blueho…
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Reid Hoffman retweeted
LinkedIn co-founder @reidhoffman speaks with Hillary Clinton on international AI cooperation: "If we actually had...a dealmaker, then maybe. I'm a little skeptical."
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Honored to back @Brendan_McCord and team.
Introducing Cosmos Ventures. @_MattMandel and I are launching Fund I with $77.6M to back philosopher-builders founding institutions for the AI age. We’ve invested in AIUC (@aiunderwriting), @PrimeIntellect, Workshop Labs (acquired by @ThinkyMachines), and a stealth education company. Our LPs include @reidhoffman, @jliemandt, @StandTogether, @fredwilson, @mickymalka, and @AsteraInstitute. AI is creating the biggest opening for institution-builders since the American founding. We are here to back the founders who take it. Our thesis: Dare to Found. xitter.cf/cosmos_vc/status/21002…
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Americans are right to demand that the AI transformation serve their needs, not just the interests of the already rich and powerful. We must deliver economic prosperity for the American people, along with AI for America.
"AI has been marketed horribly to the American people,” LinkedIn co-founder @reidhoffman said. He added that if a candidate helps Americans understand how AI could economically benefit them, then “there’s a lane for presidential candidates to be more AI positive.”👇🧵
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If companies and governments can negotiate the conditions under which AI is safe enough to advance, they can also negotiate how progress will improve everyday Americans’ lives. We must obtain economic prosperity for the many, and American AI leadership.
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We must make decisions to steer AI technology, not just away from X-risk, but towards economic prosperity for the millions of Americans who are struggling to make ends meet.
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This American generation is faced with the herculean tasks of obtaining economic prosperity for the many, and securing American AI leadership in the new world order. This is the necessary dual mandate: reidhoffman.substack.com/p/a…
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Reid Hoffman retweeted
Any pursuit of superintelligence has to be grounded in the core principle that if the AI we build is not helping humanity and under human control, it's not worth pursuing. We also need to accelerate and spread the benefits of AI, such that they are diffused broadly across countries, communities, and companies. This requires a frontier ecosystem in which both closed and open-source models can thrive. And for firms, it’s imperative that they retain full control over their unique and tacit knowledge. Every organization should be able to build its own continuous learning loop/hill climbing machine, without becoming dependent on any one model provider, and have the ability to embed its own knowledge into models and weights they control. So, in this context, we welcome the research, focus, and deliberate pacing needed to get alignment right as the design goal. We also welcome ideas like "embedded evaluators" and the broader efforts to develop the mechanisms to make this more than just talk. The key is that this cannot be controlled by a handful of entities, but must have broad representation across the ecosystem, countries, and fields, including academia. This is the approach we are taking: broad access and choice at every layer of the AI stack; enterprise control of learning loops and models; and the “Code of Conduct” that underlies our own first party MAI models that we’ll publish tomorrow for public consultation.
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Reid Hoffman retweeted
This one got to me Perhaps because he’s not an anon, but the favorite to win statewide office in Texas. Perhaps it’s because the kids in the picture could have been me 25 years ago. I just donated to his opponent and hope you’ll join me secure.actblue.com/donate/ro…
I heard UT graduation this year looked like this. I didn’t believe it. The problem is now obviously far worse than anyone imagined.
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Reid Hoffman retweeted
When everyone can generate and build, the competitive advantage shifts; instead of “Can you build it?”, the question becomes “Do you know what to build, how to test it, and when to kill it?” @markpinc @reidhoffman
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My best AI moments lately have been when the agents work overnight and prepare well-thought-out decisions for me to make in the morning. Ask your agents for decisions, not updates.
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Reid Hoffman retweeted
There is a child with a rare disease who is currently suffering and struggling to manage his symptoms. Rare as this is, you can directly help him. Today we are launching the "Rare Disease, Real Kid" Hackathon, and there are $50,000 in prizes from @AnthropicAI and @awscloud. We (@huggingface & @Sagebio) are helping this child open his genome and clinical data to the community, so that we can find what's caused his disease and what currently-approved drugs could help him. I doubt I need to motivate this much further or explain how rare it is for a family to share their child's genome and clinical data, but if you're not sure, consider this: Until very recently, it wasn't feasible for patients like this to get treatment because their disease was so rare that the economics could never justify the investment. Now, as we've seen, people with rare diseases are starting to be able to find the answers themselves (with the help of AI tools, cheaper sequencing, etc). This kid is not able to do that for himself and neither are his parents, so we're asking you for help. Both for this kid and to prove that it's possible for everyone else suffering from a rare disease. More details in 🧵. sagebio-rare-disease-real-ki…
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Some thoughts on "detecting" AI-aided essays, and whether using AI to write diminishes the value of your ideas...
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Recommend the read!
BREAKING: When today’s jobs are automated by AI, what will great human work look like? This is the most important question of our time. Introducing Thesis Statements, a new project from @every bringing together 100 builders and thinkers to call their shot: We asked them to make a specific prediction about what great human work will look like after automation. Today we’re launching the first 25 Thesis Statements from an incredible group including: • @karrisaarinen • @cjpedregal • @neuranne • @yash_tek • @komorama • @fkpxls • @jonnym1ller • @p_millerd • @sariazout • @tomcritchlow • @SimoneStolzoff And 14 more amazing builders and thinkers. At @every we believe there is a bright future for human work after automation. And we believe that there’s a small group of humans who know what it looks like—because they live the answers every day. But their ideas are still largely missing from the mainstream discourse about AI. That’s why we’re creating a public record of what people at the frontier are seeing now, so we can get these ideas to as many people as possible. We’ll also revisit them over time, and ask: Which claims held up? Which didn’t? Which became more useful as the technology changed—and which dissolved on contact with the world? Read them, argue with them, share them, and submit your own: every.to/thesis-statements-2…
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Wanted to resurface @satyanadella's recommendation of "Two Paths to Prosperity." The book traces how China and Europe developed different social organizations and how those structures shaped economic and political trajectories across a millennium. Very relevant today.
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Reid Hoffman retweeted
Sam Altman (@sama) has spent years being called untrustworthy. @reidhoffman's response: he privately funded UBI experiments years ago, with zero press attached, just to find out if it mattered. That's harder evidence of character than any statement.
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Reid Hoffman retweeted
oh my god we are so back
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