A journal dedicated to publishing the latest advances across all areas of cell biology.
NYC-Berlin-London-Shanghai
Joined February 2010
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👋🏽A reminder to all our authors and readers that you can now find us and connect with us on Bluesky: @natcellbio.nature.com
#Science #CellBiology #ScienceCommunication
☕️@ScientistJoanna, @RuggeroDavide & co perform a genome-wide CRISPRi screen and identify RBM42 as a ribosome-associated protein that modulates MYC translation and an #oncogenic mRNA program required for #PancreaticCancer growth.
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🍰Interested in reading more about the study? Here is the N&Vs article written by Zainab Hussain & Mara H. Sherman.
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bit.ly/4knA1js
☕️Oborská-Oplová et al. report a conserved #mitochondria avoidance segment in the cytosolic ribosomal protein uS5 that prevents mistargeting of uS5 to the mitochondrial matrix and ensures cytosolic #ribosomal assembly.
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🍰Interested in reading more about the study? Here is the N&Vs article written by Kanda M. Borgognoni & Robin E. Stanley.
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bit.ly/4iq3iYV
☕️Wang et al. profile the #translatome of #hematopoietic #StemCells (HSCs) and downstream progenitors and lineages. They identify the SNORD113–114 cluster as a modulator of translation and self-renewal in HSCs.
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☕️Afonso et al. show that, during #anaphase, chromosome movement can be driven by large cytoplasmic flows. These dynein-dependent cytoplasmic flows scale with cell size, slowing in smaller cells, thereby scaling anaphase.
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🍰Interested in reading more about the study? Here is the N&Vs article written by Nicoletta I. Petridou.
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☕️Interested in how cells respond to #mitochondria #ProteinImport stress? Read our Review article by Nikolaus Pfanner, Fabian den Brave & Thomas Becker.
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☕️@szmyd_radoslaw @TheCesareLab @RadOncDoc_Gee & co: #DNArepair pathways impact if cells with DNA lesions arrest in mitosis. Homologous recombination-driven double Holliday junction formation elicits mitotic #CellDeath & suppresses inflammatory signaling.
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☕️@JingtaoGuo, @LeqianYu & co characterize an intact Carnegie stage 7 #HumanEmbryo at single-cell resolution in a spatially resolved manner.
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☕️Fulcher et al. show that #MDM2 times mitosis through self-catalysed ubiquitination and proteasomal destruction, triggering G1 arrest following delays in #mitosis associated with chromosome instability and #aneuploidy.
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☕️Ma et al. show that heterogeneous nuclear ribonucleoprotein U promotes the primed state in human #pluripotent stem cells by interacting with #NuclearMatrix protein, Matrin-3, and regulating primed-specific genes.
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💫NEW: @Brumbaugh_JB, Dempsey & co show that #H3K36 methylation maintains #intestinal epithelial fate commitment, whereas its suppression induces a plastic state and expression of genes involved in #regeneration.
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nature.com/articles/s41556-0…
💫NEW: @Sloan_Lab, @CaitlinSojka & co analyse the transcriptomic & epigenomic landscape of human #astrocyte maturation and identify an epigenetically regulated intermediate state linked with aberrant development in #glioblastoma.
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nature.com/articles/s41556-0…
💫NEW: @Zak_Bakes @Pagliarini_Lab & co show that #mitochondria stress recovery requires mobilization of #LipidDroplet triacylglycerol stores to facilitate #cardiolipin biosynthesis and mitochondrial biogenesis.
nature.com/articles/s41556-0…
🍰Interested in reading more about the study? Here's the Research Briefing:
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nature.com/articles/s41556-0…
💫NEW: Hervé, Scelfo et al. show that #chromosome missegregation induces #mTORC2 - & ATR-mediated p53 activation via a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension.
nature.com/articles/s41556-0…
🍰Interested in reading more about the study? Here's the N&Vs article written by Joana C. Macedo, Maria M. da Silva & Elsa Logarinho.
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nature.com/articles/s41556-0…