Nature Methods (@naturemethods)

A compact protein pair, FenixS and Ash1, heterodimerizes upon red light activation for optogenetics. nature.com/articles/s41592-0…

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Nature Methods · Sep 22, 2026 · 5:39 PM UTC

WILD: a wireless device for studies of brain activity in freely moving animals under naturalistic conditions. nature.com/articles/s41592-0…

A wireless modular platform for neuro-behavioral recording and closed-loop manipulation in small...

Nature Methods - WILD is a wireless device that can record neuronal activity, perform optogenetic stimulations, record animal movements, record the environment or eye movements via an integrated...

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Nature Methods · Sep 22, 2026 · 5:39 PM UTC

Read the associated Research Briefing here: nature.com/articles/s41592-0…

Wireless neural recordings from groups of mice inside and outside the laboratory

Nature Methods - Studying the brain mechanisms of natural behaviors is experimentally challenging. We developed a miniaturized, wireless platform to record and manipulate neural and physiological...

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Nature Methods · Sep 22, 2026 · 5:20 PM UTC

MemBrain v2: streamlined analysis of membranes in cryo-ET with tools for membrane segmentation, protein localization and spatial analysis. nature.com/articles/s41592-0…

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Nature Methods · Sep 22, 2026 · 5:15 PM UTC

IRIS learns conserved signaling representations from in vivo perturbation data to reconstruct cell signaling states and histories. nature.com/articles/s41592-0…

Reconstructing signaling histories of single cells via perturbation screens and transfer learning

Nature Methods - IRIS learns conserved signaling representations from in vitro perturbation data to reconstruct signaling states and histories across diverse in vivo cellular contexts.

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Nature Methods · Sep 18, 2026 · 2:54 PM UTC

DeepWonder3D: a pipeline for neuronal extraction from volumetric calcium imaging data. nature.com/articles/s41592-0…

Rapid robust high-fidelity 3D neuronal extraction from multiview calcium imaging datasets

Nature Methods - DeepWonder3D is a pipeline for neuronal extraction from volumetric calcium imaging data acquired with a variety of one-photon or two-photon microscopy modalities.

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Nature Methods · Sep 18, 2026 · 2:40 PM UTC

Spatial isoform sequencing at single cell resolution, as demonstrated in mouse brain slices. nature.com/articles/s41592-0…

Spatial isoform sequencing at single-cell resolution reveals cell-type-specific spatial isoform...

Nature Methods - Spl-ISO-Seq2, Spl-IsoQuant-2 and Spl-IsoFind enable isoform sequencing, barcode calling of >450 million barcodes, and spatially variable isoform detection with high spatial...

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Nature Methods · Sep 18, 2026 · 2:25 PM UTC

Iterative Mapping of proteoforms technology allows measuring intact proteoforms at the single molecule level. nature.com/articles/s41592-0…

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Nature Methods · Sep 18, 2026 · 2:25 PM UTC

Read the News & Views highlighting this interesting work, here: nature.com/articles/s41592-0…

Revealing distinctive traits of individual proteins

Nature Methods - Tau: distinguishing the good, the bad and the ugly.

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Nature Methods · Sep 10, 2026 · 3:05 PM UTC

Sep 10

Our September issue is live! 🎉 nature.com/nmeth/volumes/23/… This special issue includes a Focus on AI in biological research. AI is everywhere these days, and is impacting nearly all fields of biology. To learn more, read our Editorial and check out the focus content!

Nature Methods - Focus on AI in biological research

This month, several review and opinion pieces discuss how AI is having an impact across nearly all areas of biological research.See Editorial

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Nature Methods · Sep 10, 2026 · 3:05 PM UTC

Sep 10

Perspective: nature.com/articles/s41592-0…

Open and sustainable AI: challenges, opportunities and the road ahead in the life sciences

Nature Methods - This Perspective provides recommendations for open and sustainable AI and associated resources facilitating exploration and implementation.

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Nature Methods · Sep 10, 2026 · 3:05 PM UTC

Sep 10

Review: nature.com/articles/s41592-0…

AI-empowered super-resolution microscopy: a revolution in nanoscale cellular imaging

Nature Methods - This Review provides a comprehensive discussion of how methods in machine learning and computer vision have been used to improve super-resolution microscopy to gain insights into...

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Nature Methods · Sep 3, 2026 · 8:46 PM UTC

Sep 3

In our latest Technology Feature, @CarolineSeydel explores how mechanical forces such as tension and compression influence tissue differentiation, and how cell biologists are observing and manipulating such forces in living systems. nature.com/articles/s41592-0…

The physics of sculpting a living creature

Nature Methods - Cell biologists have long known that mechanical forces, such as tension and compression, influence tissue differentiation. Now, advanced methods are letting them observe and...