A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
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Our October issue is live!
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Inspired by the phases of the moon, the cover artwork uses light and darkness to depict pharmacological control of chimeric antigen receptor (CAR) T cells
A selective NVL inhibitor suppresses tumor growth by targeting ribosome biogenesis
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PUS7 pseudouridylation of noncoding RNA 7SK orchestrates human somatic cell reprogramming into iPS cells
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Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity
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High-resolution NMR spectroscopy of proteins in intact mitochondria
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QC6352, originally developed as a KDM4 inhibitor, exerts its anticancer activity in glioblastoma models primarily through inhibition of DHODH, a key enzyme in de novo pyrimidine biosynthesis
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Cell-cycle-driven noncanonical ubiquitination of METTL14 orchestrates RNA methylation
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Cryo-EM structures of RNA polymerase II (Pol II) with cisplatin-induced DNA interstrand crosslinks (ICLs) reveal how Pol II remodels cisplatin-ICLs, stalls transcription, and commits lesions to transcription-coupled repair
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A nontoxic proximity labeling method generating H2O2 in situ from D-amino acids enables protein and RNA proximity labeling and mapping RNA structural changes in vitro and in vivo
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SRSF1 modulates the dark nucleolar cap pH to restore nucleolar integrity and function
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A new Review highlights the mechanisms of molecules that disrupt translation in an amino acid or mRNA sequence-dependent manner
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Small-molecule inhibitors of S. aureus efflux pump NorA trap NorA in an outward-open state, preventing antibiotic efflux and restoring antibiotic susceptibility
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Allenes and alkynes can be biosynthesized via oxidative C(sp2)-demethylation of a prenyl group by fungal cytochrome P450s, expanding the catalytic repertoire of P450 enzymes
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Discover groundbreaking research and innovation in chemical biology at the Tri-Institutional Chemical Biology Symposium
AvaS is a pyridoxal-phosphate-dependent RNA-modifying enzyme, producing the tRNA modification ava2C from k2C in bacteria and plants and linking RNA chemistry to translational regulation of metabolic stress responses
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A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes
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Plasma membrane order maps functional diversity in immune cells
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Macrophages transfer functional proteins to their surface during live-cell uptake
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Directed evolution of Lantern enables rapid RNA and protein proximity labeling
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Nature Chemical Biology retweeted
Loss of function for 1 gene can make a cancer cell resist a DNA damage response (DDR) inhibitor, while another gene can make it easy to kill. Core Investigator @LukeGilbertSF and collaborators mapped both across five DDR inhibitors and found loss of PRDX1 sensitizes cells to all five.
