University of Chicago head and neck cancer lab doing research at the interface of computational methods, tumor biology, and clinical relevance. PI: Alex Pearson
Hyde Park, Chicago
Joined May 2018
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Excited to share our new #AI framework for harmonizing medical #foundationmodel *embeddings* across acquisition conditions and models🔬🩻💻.
We propose using paired data and a single global affine transformation per model, that we call FEATMAP
Preprint: doi.org/10.64898/2026.07.02.…
We tried this in some useful contexts:
- Digital pathology (with scanner + foundation model harmonization)
- Brain MRI (1.5T ↔ 3T field-strength harmonization)
To do all this we generated almost 300M precision matched FM-based embeddings to test the alignment impact.
Pearson Lab retweeted
Congratulations to #SlideflowLabs, @UChicago spun out cancer pathology AI company on winning Rattan L. Khosa First Place Prize. #SlideflowLabs enables hospitals to run cancer biomarkers in-house with faster turnaround times. @lab_pearson @UChicagoPath
ow.ly/eTYS50Z8NRA
Pearson Lab retweeted
🤖 Join the Artificial Intelligence in Cancer Research Summer School 2025 hosted by @IstTumori- A pioneering event where cutting-edge technology meets life-saving medical innovation. More info ➡️ aicancer2025.org
Pearson Lab retweeted
At #ASCO25, Frederick Howard, MD, presents a poster showing high efficiency of AI models that accurately predicts treatment outcomes in breast cancer patients, offering a faster, more scalable alternative to traditional genomic testing.
@fredhow @lab_pearson @UChicagoHemOnc
Pearson Lab retweeted
From ambient dictation tools to FDA-approved diagnostics, #AI is transforming oncology!
At #ASCO25, Alexander Pearson, MD, PhD presents how AI is reshaping clinical cancer care—from research to bedside. @UChicagoMed @UChicagoHemOnc @lab_pearson
Pearson Lab retweeted
🧐Our DEPEND trial is out! Neoadjuvant nivo/chemo followed by response-stratified CRT in HPV-negative stage IVa/b HNSCC. @UCCancerCenter @UChicagoHemOnc @ajuloorimd @lab_pearson @HNCancerDoc @EIzumchenko @eevokes jamanetwork.com/journals/jam…
Jazzed to see our work describing *potential LLM use trends in @ASCO abstracts* as one of the @JCO_ASCO family top articles of 2024. Check out all the top articles here: ascopubs.org/2024-top-articl…. @fredhow @LGM_Biostats @JCOCCI_ASCO @UCCancerCenter @UChicagoBSD
Pearson Lab retweeted
The #callforabstracts for our annual AI for Oncology conference in @IstTumori (May 8-9, 2025) is open until Feb 3rd - aiforoncology.it/call-for-ab… We really look forward to your submissions! And the top 3 will have the chance to present in front of a stellar lineup - don't miss it!
Thanks so much @BasuLab1 @LovaSunMD @PennHeadandNeck! What a great opportunity to brainstorm science together.
It was a privilege to host @lab_pearson together with @LovaSunMD as part of our Head and Neck Cancer Center of Excellence lecture series and learn about progress toward AI-based discrimination of actionable states for cancer therapy.
Pearson Lab retweeted
Generative artificial intelligence for drug discovery: how the first AI-discovered and AI-designed drug progressed to phase 2 clinical testing
#behindthepaper communities.springernature.c…
Pearson Lab retweeted
Honored to present our translational research at @TheVFoundation symposium. Thank you for the invtation and your support! @UCCancerCenter @UChicagoMed @UChicagoHemOnc @UofC @UChicagoCCB
It’s personal for our researchers. @AkashPatnaik7 from @UChicagoMed shares how he lost his uncle to prostate cancer and how that gave him the drive to research this type of cancer.
Pearson Lab retweeted
Incredibly excited to share our open-source Common Longitudinal ICU data Format (CLIF)! We hope CLIF will substantially improve the efficiency of critical illness research and evaluation of important ICU quality measures
Appreciate any and all feedback!
🚨 Just released! 🚨 Excited to share our new preprint on the Common Longitudinal ICU Data Format (CLIF)! This open-source format standardizes ICU data for federated research, advancing AI and critical care research. Check it out: (medrxiv.org/content/10.1101/…) #ICU #DataScience #AI
Pearson Lab retweeted
🚀 Big news! Slideflow 3.0 is here! 🎉 We've revamped our licensing (now Apache-2.0) to make Slideflow more open & accessible. We've added 3 foundation models (Virchow, UNI, GigaPath), upgraded MIL, & much more. Check it out: github.com/slideflow/slidefl… #AI #Pathology #OpenSource
Fantastic news!
Thank you @woldloren! I am honored to receive this award from @ConquerCancerFd. I have been blessed with incredible mentorship on this project from the Applebaum lab @UChiPritzker @d_golden @lab_pearson & @spshubeck. Excited to present @ASCO!
conquer.org/news/conquer-can… @FutureDocs
Pearson Lab retweeted
Check out our multi-center phase 2 IIT currently accruing for upfront SBRT added to Durvalumab-based chemoimmunotherapy for the first line treatment of extensive stage SCLC - the DARES trial. @ChristineBestv1 @Docace911
clinical-lung-cancer.com/art…
Looking forward to this terrific session!
🔜#ASCOBT24 Day1⃣
🔥Artificial Intelligence in the Cancer Clinic
✅Overview: Chair &🎙️@lab_pearson
✅Pathology: 🎙️Joe Poh Sheng Yeong
✅Large Language Models:🎙️Danielle Sara Bitterman
✅Precision oncology: 🎙️Caroline Chung
@OncoAlert @ASCO @JSMO_official
conferences.asco.org/breakth…
