Cardiologist MBBS, MD, FACC, FESC | Physician-Sci & Researcher MPH, DMSc | #HeartFailure 🧑⚕️| #HFA Committee @escardio | Content Catalyst @TCTMD
USA | Earth 🌎
Joined July 2017
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The updated @escardio #HeartFailure guidelines
#ESCCongress @escardio @ESC_Journals @hvanspall @DrMarthaGulati @mmamas1973 @mirvatalasnag
Henry Han retweeted
Drug-Coated Balloons vs Drug-Eluting Stents: What Does the Evidence Show?
Our new meta-analysis of 10 RCTs (7,832 patients) led by @CorballisTash
@TheLancet @eClinicalMed
No difference in cardiovascular death or MI. But revasc may be higher.
thelancet.com/journals/eclin…
@NNUH
Henry Han retweeted
For those following the latest in heart failure research, this is worth bookmarking.
What’s new in heart failure? September 2026
academic.oup.com/eurjhf/adva…
@ESC_Journals #EJHF @EJHFEiC @GianluSava
Henry Han retweeted
Heart Transplant for Advanced #HeartFailure : A Review
Management of Adult Patients With Advanced Heart Failure Before and After Heart Transplant
jamanetwork.com/journals/jam…
@JAMA_current @JAMACardio
Henry Han retweeted
🫀Interplay between acute heart failure and COPD in patients hospitalized for dysponea: prognostic insights from the PARADISE cohort
ow.ly/2scR50ZYj3R
@EJHFEiC @AmrAbdin10 @GiuseppeGalati_ @HanCardiomd @EJHFEiC @JanBiegus @ppponikowski #HFA_ESC @hvanspall @FudimMarat @gcfmd @MarcoMetra @GianluSava
#ESCHeartFailure
Henry Han retweeted
Longitudinal proteomic organ-specific ageing in heart failure
How organ-specific ageing evolves within individuals over the course of HF ?
academic.oup.com/eurjhf/adva…
#EJHF @HanCardiomd @AmrAbdin10 @GiuseppeGalati_
What’s new in heart failure? September 2026
academic.oup.com/eurjhf/adva…
@ESC_Journals #EJHF @EJHFEiC @GianluSava
Henry Han retweeted
9) This study (🔓ahajournals.org/doi/10.1161/… ) also reported that CV 🏥 burden in #ATTR-CM varied across age, race, and geographic subgroups, with differences in length of stay #LOS and annual days hospitalized.
#ATTRCM #Amyloidosis #HeartFailure
Early Uptake of Oral #Semaglutide for Obesity Treatment After Regulatory Approval
acpjournals.org/doi/10.7326/… @ACPIMPhysicians @AnnalsofIM
Genotype and arrhythmic risk in #DCM
: International Sarcomeric Human Cardiomyopathy Registry (SHaRe)
📍2,660 adults with DCM: 16% carried pathogenic/likely pathogenic variants in high-arrhythmogenic-risk genes; 17% in low-risk genes; 67% were gene-elusive.
📍3.25× higher risk of major VAs in patients with high-risk genetic variants vs. gene-elusive patients.
📍 Beyond arrhythmias: High-risk variants were associated with ⬆️ risks of #AFib (HR 2.42) and #HeartFailure (HR 2.46).
📍Preserved #LVEF doesn’t eliminate risk: Even with LVEF ≥50%, high-risk variant carriers had a 2.36× higher risk of major #VAs
academic.oup.com/eurheartj/a… @ESC_Journals @ehj_ed
#Amiodarone Patch Doesn’t Prevent Postoperative AF After Cardiac Surgery: #BEAT-AF
tctmd.com/news/amiodarone-pa…
Henry Han retweeted
Its not about more or less fluids. Its about giving patients the right hemodynamic support based on their physiology!
Some patients in early septic shock are:
1. Fluid responsive with low SV --> fluids
2. Fluid unresponsive with low SV --> pressors, inotropes
3. Fluid responsive with high SV --> pressors
4. Fluid unresponsive with high SV --> pressors
5. Congested --> inotropes + diuresis
6. Impaired microcirculation with hemodynamic coherence --> fix macrohemodynamics
7. Impaired microcirculation with hemodynamic incoherence --> MAP target, avoid edema, other? (anticoagulation)
We need to stop treating "septic shock" as hemodynamic paradigm.
Among adults with septic shock, the use of restricted fluids and early vasopressors did not result in more days alive and out of the hospital through day 90 than the use of liberal fluids and later vasopressors. Full ARISE FLUIDS trial results and Research Summary: nej.md/3PVdwIp
ALT This image contains an excerpt from the Research Summary "Vasopressors or Fluids in Early Septic Shock” published in the New England Journal of Medicine. It includes a depiction of a patient with septic shock. The summary outlines a study with 1000 adults, median age 68, 60% men, and 40% women. Two groups are compared: "Vasopressor Group," with restricted fluids and early vasopressors, and "Fluids Group," with liberal fluids and later vasopressors. There are illustrations representing each group. A prompt to read the full Research Summary at NEJM.org sits at the bottom.
Henry Han retweeted
15) 📊 #ATTRIBUTE_CM 🔑 Takeaway: In pts with #ATTRCM, higher NTproBNP & lower sTTR identified those at greatest risk of mortality/#CVH, while #acoramidis reduced clinical events regardless of baseline biomarker levels. 🫀
#ATTRCM #Amyloidosis #HeartFailure #Cardiology
Henry Han retweeted
31) #ACO-REAL trial will help answer;
👉 How is #acoramidis being used, tolerated, and continued in routine ATTR-CM practice beyond the controlled clinical-trial setting?
📊 Real-world data may help inform treatment decisions and patient management.
Henry Han retweeted
32b)
📌 Rx options: TTR stabilizers and gene silencers have expanded the disease-modifying treatment landscape.
📌 Personalize therapy: Consider efficacy, safety, treatment burden, adherence, and patient preferences when selecting therapy.
Henry Han retweeted
32a) So . . . Take-Home Messages
📌 Think early: Early diagnosis and treatment are critical before irreversible end-organ damage.
📌 Know the phenotype: ATTRv-PN and ATTRv-CM require phenotype-specific treatment strategies.
Henry Han retweeted
1) Welcome to a new #accredited #tweetorial and an update on #ATTR_CM examining the most interesting & important data published in 3Q 2026! We welcome back expert faculty Han Naung Tun (aka Henry Han) MD @HanCardiomd, #cardiologist Physician-Sci & Researcher #HeartFailure
In #HFpEF, prominent #PAWP V waves may identify a high-risk LA myopathy phenotype.
Among 1,069 patients undergoing invasive exercise testing, 21% had prominent V waves and showed:
📍 Larger #LAVI: 42.2 vs 32.5 mL/m²
📍 Lower LA reservoir strain: 16.4% vs 23.2%
📍 AF: 61.3% vs 22.9%
📍 PA systolic pressure: 54 vs 38 mmHg
📍 Lower PA compliance: 3.03 vs 4.90 mL/mmHg
V-wave correction reduced apparent combined pre/post-capillary PH from 60.2% → 29.3%.
Prominent V waves were associated with worse RV function/exercise reserve and 2× higher risk of HF 🏥 or ☠️ (adjusted HR 2.09).
ahajournals.org/doi/10.1161/…
@CircAHA
Henry Han retweeted
🧬 From phenotype to precision medicine in #Cardiomyopathy
An insightful #EJHF review explores how genetics, advanced imaging & deep phenotyping can improve the management of DCM & NDLVC:
📍DCM & NDLVC represent a disease continuum, sharing genetic backgrounds but with potentially different clinical trajectories.
📍Phenotype is the starting point, not the final diagnosis. Integrate clinical assessment, ECG, echo, CMR & genetics.
📍Genotype matters. Different variants are associated with distinct clinical trajectories, for example;
- LMNA: Conduction disease & arrhythmias
- FLNCtv: High arrhythmic burden, fibrosis & SCD risk
- DSP: Arrhythmias, fibrosis & myocarditis-like episodes
📍Arrhythmic risk goes beyond LVEF. Consider genotype, arrhythmia burden & CMR fibrosis/LGE when assessing risk and ICD decisions.
📍Consider genetic testing in DCM/NDLVC. Results may guide family screening, risk stratification & management
📍Precision medicine is evolving. Gene-directed therapies are emerging, while GDMT remains the cornerstone of HF management.
Read more @EJHFEiC🔗: doi.org/10.1093/ejhf/xuag224
@escardio @rudolf_deboer @h_arfsten @jozinetm @GTersalvi
