2025 put health systems under enormous pressure, from conflict and climate shocks to rising debt and unprecedented cuts to development assistance. Yet amid that historic uncertainty, countries continued to expand protection against preventable disease, reach more children and invest more of their own resources in immunisation. Gavi’s latest Annual Progress Report captures the scale of that progress, and the work that still lies ahead. Scroll down through eight numbers that help tell the story of 2025, and read more about what sustained investment in vaccines has made possible on VaccinesWork: bit.ly/4jJbqrh

We know vaccinated children have better education outcomes, but could classrooms be the key to higher vaccination rates? In Malawi, school-based vaccinations supported by parent-teacher associations are proving effective in the battle against a measles resurgence: bit.ly/4ySHdeh

Trust in science is falling fastest among people facing financial insecurity. A new global survey from @wellcometrust spanning 140 countries found that people who feel left behind are also less likely to say they trust science, especially when healthcare and the benefits of research feel out of reach. Read the full story: bit.ly/4inkUaK via @scidevnet

Zero preventable maternal deaths. Zero preventable child deaths. Zero zero-dose children. Through its "300 days of Activism for Triple Zero" initiative, Sierra Leone's Ministry of Health has set an ambitious agenda to eliminate preventable losses during pregnancy, birth, and early childhood. 226 days in, preliminary data show promising impact across the country: bit.ly/4yK0JJT

About half of infants eligible for immunisation in Brazzaville’s Moungali district had missed out on any vaccines, leaving them vulnerable to deadly diseases. One big reason? Only 8 of 24 health facilities offered routine vaccination. Now, a clinic trusted for maternal care has become the district’s ninth fixed vaccination site. How expanding care in places mothers feel safe is helping close the gap: bit.ly/4yeU752

Cervical cancer is preventable, and we are accelerating the fight to eliminate it. In 2025, a record-breaking 35 million+ girls received the HPV vaccine in a single year, bringing the number of girls to 95 million. Learn more about this historic moment and other 2025 immunisation milestones: gavi.org/progress-report

A study of 60,000 women confirms that COVID-19 vaccines have no impact on fertility or pregnancy outcomes. Dig into the findings: bit.ly/4aoYUXH

Two children can catch the same virus and have very different outcomes. A new study of 333 South African children found distinct patterns of gene activity and immune response in those with severe respiratory infections, including COVID-19. Here’s what scientists are learning: bit.ly/4yvw960 via @ConversationUK

Just how bad will this winter’s flu season be? The southern hemisphere – now wrapping up their own winter season – offers some clues, and so far the picture looks fairly moderate. Here’s what we know so far and what researchers are still closely watching: bit.ly/4BnooBI

Ghana’s progress against malaria is remarkable: a 98% drop in malaria deaths between 2011 and 2025. And it hasn’t come from one intervention: vaccines, bed nets, preventive medicines, spraying, treatment and stronger public engagement are all working together to drive deaths down. With elimination now considered within reach, here’s how Ghana is getting closer to eliminating one of the world’s oldest diseases: bit.ly/4e80yQg

In 2000, as many as one in four children in Sierra Leone were not expected to make it to their fifth birthday. This led authorities to set a hugely ambitious target for the country: 0️⃣ preventable maternal deaths 0️⃣ preventable child deaths 0️⃣ zero-dose children Here’s where things stand more than two thirds of the way into its 300-day “Triple Zero” campaign: bit.ly/4yK0JJT

Outbreaks move fast, so our responses must move faster. ✈️ One way we do that is with VACCINE STOCKPILES. But how do they actually work? From 48-hour emergency approvals to shipping millions of doses around the world at a moment's notice, our latest VaccinesWork YouTube explainer breaks down the global good keeping us all safe. 🎬 Watch the full video on YouTube and let us know what vaccine topics you'd like us to explore next. ➡️ youtube.com/watch?v=GUwz0mJ0…

When people move across borders, healthcare can easily be interrupted. Malawi’s response to almost 60,000 returning citizens included something simple but important: checking children's vaccination status and they arrived, and helping them catch up on any missed doses before they continued home. Here’s why that matters for children and wider outbreak prevention alike: bit.ly/479jgmI