@fodorlab

We're a molecular and structural virology lab working mainly on influenza @Dunn_School, @UniofOxford

 Oxford, England
fodor.path.ox.ac.uk/
Joined November 2020
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  • Following458
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Cryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Great teamwork of @RepAlison @FangzhengWang @Husky17146986 @CarriqueLoic @jonathan_grimes science.org/doi/10.1126/scia…
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Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis science.org/doi/10.1126/scie…

Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis

Highly pathogenic avian influenza viruses (HPAIVs) derive from H5 and H7 low pathogenic avian influenza viruses (LPAIVs). Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in...

science.org
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Fodor Laboratory retweeted
nature
@NatureMar 9
Nature research paper: Mechanism of co-transcriptional cap snatching by influenza polymerase go.nature.com/4rTklIc

Mechanism of co-transcriptional cap snatching by influenza polymerase

Nature - Structural and biochemical studies of influenza virus RNA-dependent RNA polymerase (FluPol) in complex with transcribing host RNA polymerase II reveal the molecular mechanisms of RNA cap...

nature.com
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Fodor Laboratory retweeted
Achillefs Kapanidis@AchillesKapJan 30
Great to see our new Science Review on emerging multiplexed measurements that link the sequence of single molecules to their dynamics! From sequence to function: Bridging single-molecule kinetics and molecular diversity | Science science.org/doi/10.1126/scie…

From sequence to function: Bridging single-molecule kinetics and molecular diversity

Biological function is fundamentally determined by nucleic acid and protein sequence. Beyond encoding genetic information, nucleic acids also display complex physicochemical parameters that shape...

science.org
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Decoding influenza virus: From polymerase mechanisms to translational therapeutics sciencedirect.com/science/ar…
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Very happy to have been able to contribute to this study that was published today in Science, which was truly a great collaborative effort. Avian PB1 provides a fitness advantage to IAV at febrile-range temperatures both in vitro and vivo 🦠 #flu #virology science.org/doi/10.1126/scie…

Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted...

science.org
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Officially starting my DPhil in Condensed Matter Physics in @AchillesKap and @fodorlab ! A collaborative project to understand influenza dynamics. Excited to see where this project goes!
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Congratulations @AlexBoRNA!
Biochemical Society@BiochemSoc29 Aug 2025
Congratulations to @AlexBoRNA who presented the 2025 Colworth Medal Lecture today! Alex discussed how his work positions viral replication organelles as tractable systems for dissecting the biophysical principles underpinning RNA selection and turnover #BiochemAwards
Dr Hannah Burgess, Imperial College London and Dr Alex Borodavka, University of Cambridge. 

ALT Dr Hannah Burgess, Imperial College London and Dr Alex Borodavka, University of Cambridge. 

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Daniel Weir@DanielWeirIAV6 Jun 2025
🚨🔎 Out now in @PLOSPathogens! 🔎🚨 This project has taken us @CVRinfo @UofGMVLS on a wild and wonderful journey. I am excited to share our story of how influenza A viruses (IAVs) exploit cell death to facilitate its covert spread. N/1 journals.plos.org/plospathog…
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There is still time to apply; join our team to work on influenza virus replication mechanisms!
Fodor Laboratory@fodorlab7 May 2025
📢 Exciting job opportunities!📢 Two postdoc positions are available in our lab at @Dunn_School to study influenza virus transcription, genome replication, nuclear export and assembly. More info: my.corehr.com/pls/uoxrecruit…
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📢 Exciting job opportunities!📢 Two postdoc positions are available in our lab at @Dunn_School to study influenza virus transcription, genome replication, nuclear export and assembly. More info: my.corehr.com/pls/uoxrecruit…
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Europe needs a sustainably funded influenza research and response network - especially in the light of H5N1 and current developments in the US. Read our commentary in The Lancet ID: thelancet.com/journals/lanin… With @wendybarclay11, @MarionKoopmans and many other colleagues.

Europe needs a sustainably funded influenza research and response network

Influenza viruses have caused four pandemics during the last century.1 The 1918 H1N1 pandemic claimed 20–50 million lives, the 1957 H2N2 pandemic and the 1968 H3N2 pandemic claimed 1–4 million lives...

thelancet.com
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Very concerning to see a second introduction of H5N1 I to dairy cattle. It’s been reported to be from the D1.1 genotype which is widely circulating in birds in North America. It will be critical to examine the sequences for signs of host adaptation 🦠🐄 statnews.com/2025/02/05/usda…

USDA milk testing shows different strain of H5N1 bird flu in Nevada dairy herds

The USDA said four Nevada dairy herds were infected with an H5N1 bird flu strain that has circulated in wild birds, making prospects for containment in cows appear dim.

statnews.com
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Decoding viruses. Defying limits. 🦠🔍 Prof @wendybarclay11 has dedicated her career to unpicking viral mysteries. Now, she's been appointed Regius Professor—the first woman to hold the prestigious title at @imperialcollege ⤵️ #WomenInSTEM imperial.ac.uk/Stories/Wendy…

Decoding viruses and defying limits: Professor Wendy Barclay appointed Regius Professor

A life dedicated to understanding viruses with pandemic potential

imperial.ac.uk
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Fodor Laboratory retweeted
Jeremy Farrar@JeremyFarrar1 Feb 2025
Virologist Wendy Barclay: ‘Wild avian viruses are mixing up their genetics all the time. It’s like viral sex on steroids’ Always worth listening to ⁦@wendybarclay11⁩ ⁦@imperialcollege⁩ theguardian.com/science/2025…

Virologist Wendy Barclay: ‘Wild avian viruses are mixing up their genetics all the time. It’s like...

The British scientist on the risk of humans contracting bird flu, how people would cope with new lockdowns and being asked to pour the tea because she is a woman

theguardian.com
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Fodor Laboratory retweeted
Alex Borodavka@AlexBoRNA12 Jan 2025
Interested in joining our growing interdisciplinary team studying viruses, RNA, and condensates? Looking for a postdoctoral position? Please consider joining us in Cambridge, UK, or drop us a line to discuss these opportunities: jobs.cam.ac.uk/job/49901/
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Fodor Laboratory retweeted
Nicole Robb@nicole_robb111 Dec 2024
An image representing our work made the cover of Biophysical Reports! If you're interested check out the paper at cell.com/biophysreports/full…. Thanks again to everyone involved @CVRHutchinson @SwethaVijayakr1 @daniellegroves_ @Hafezelsayyed and not-on-X Andrew McMahon :)
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Just published—avian origin and pandemic PB1 genes from influenza A viruses influence replication and pathogenesis in an avian influenza viirus. Happy for this story to be out and thank you to my co-authors 🦠 #influenza #virology #womeninSTEM science.org/doi/10.1126/scia…

Effect of pandemic influenza A virus PB1 genes of avian origin on viral RNA polymerase activity and...

Past influenza pandemics contained polymerase genes from avian influenza viruses, affecting viral replication and pathogenicity.

science.org
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The abstract submission for the Annual Meeting of the Society for Virology (GfV, @GesVirologie) is open till 1 December 2024! GfV is officially affiliated with our Journal of General Virology (#JGenVirol).Don't miss the opportunity to share your research! microb.io/3NMmClQ
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There is nothing more scary than a pumpkinfluenza! Rescued by @fodorlab graduate student not-on-X Tom Shimkus.
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