@DiMicheleLAB1

Lorenzo Di Michele's research group @cebcambridge @MemBiophysIC @fabriCELL_UK #Nanotechnology #SyntheticCells #Biophysics

 Cambridge, United Kingdom
dimichelelab.org
Joined May 2018
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  • Following670
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Great new @J_A_C_S paper by @rogerrubio. Please check it out!
Roger Rubio Sánchez@rogerrubio8 Sep 2025
Really happy to see this published in its final form @J_A_C_S! 🧬 In this paper, we introduce a new class of biomimetic receptors to host functionality in synthetic cell membranes Elita Peters @dianatanasedt @DiMicheleLAB1 pubs.acs.org/doi/10.1021/jac…

Cation-Controlled Assembly, Activity, and Organization of Biomimetic DNA Receptors in Synthetic...

Abstract. Biological cells use cations as signaling messengers to regulate a variety of responses. Linking cations to the functionality of synthetic membra

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Very excited about this one! Sequence-specific interactions between dsDNA accurately quantified + modelled 🧬! New preprint by Andy Stannard + Ehud Haimov, @JonathanGHedley from Alexei Kornyshev's team and many others. Let us know what you think! chemrxiv.org/engage/chemrxiv…

Direct evidence and quantification of homologous recognition between DNA duplexes | ChemRxiv

Stretches of double-stranded DNA sharing the same sequence can recognise each other in cells. This phenomenon, known as homologous recognition, is essential for DNA recombination and repair. Yet, its...

chemrxiv.org
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Thrilled to share this new Adv. Sci. paper by @dianatanasedt with Dino Osmanovic @rogerrubio Layla Malouf and Elisa Franco. We demonstrate a modular approach to program internal phase separation in DNA condensates 1/n advanced.onlinelibrary.wiley…

Internal Phase Separation in Synthetic DNA Condensates

The modular, programmable system of DNA nanostructures developed provides programmatic control over multiphase condensate behavior, enabling mapping onto a predictive Flory-Huggins model. This...

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Condensates assemble from two populations of tetravalent DNA nanostars, and three types of divalent linkers that mediate nanostar-nanostar interactions, either within the same nanostar population or across populations 2/n
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We can control phase behaviour by changing linker and nanostars concentrations, without re-designing nanostructures. This is convenient, and allowed us to map a large phase diagram and identify an order parameter controlling the transition between 1- and 2-phase condensates 3/n
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Thrilled to share our latest preprint on expressing synthetic organelles made from RNA nanostructures in bacterial cells. Great work from @BrianNgSH, Catherine Fan, @milandordevicc, Adam Knirsch, coll. Graham Christie @TakinoueLab @CicutaGroup 1/n biorxiv.org/content/10.1101/…

Expression of nano-engineered RNA organelles in bacteria

Designing synthetic biomolecular condensates, or membrane-less organelles, offers insights on the functions of their natural counterparts, and is equally valuable for cellular and metabolic enginee...

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The MLO platform is robust, inducible and modular and many design modifications can be applied to the nanostars to capture different proteins or change MLO properties. Hopefully you’ll find this useful, and we look forward to your feedback! 7/n
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Thanks also @rogerrubio Layla Malouf, @FabriniGiacomo Sabrina Pia Nuccio @cebcambridge and funding from @ERC_Research @BBSRC @royalsociety n/n
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DiMicheleLAB retweeted
Yuval Elani@YuvalElani23 Jun 2025
Check out our PhD student Hannah Sleath’s paper on vesicle-based synthetic cells that can crawl up surface concentration gradients using DNA receptors — great collaboration with @DiMicheleLAB1 and @BMognetti pubs.acs.org/doi/full/10.102…

Haptotactic Motion of Multivalent Vesicles Along Ligand-Density Gradients

Abstract. Multivalent adhesion between cell-membrane receptors and surface- or particle-anchored ligands underpins a range of active cellular processes, su

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Check out @evelucinskaite's recently published work reducing non-specific interactions of DNA-PAINT secondary antibodies. You may find it particularly useful if you are interested in super-resolution imaging of nuclear targets: doi.org/10.1002/smll.2024050…

Reduced Non‐Specific Binding of Super‐Resolution DNA‐PAINT Markers by Shielded DNA‐PAINT Labeling...

Conventional immunohistochemistry labeling with oligonucleotide conjugated secondary antibodies can lead to significant non-specific uptake across biological cells and is especially prominent within...

onlinelibrary.wiley.com
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Happy new year everyone, and some great news! We have an opening for a PhD candidate to join our lab @cebcambridge @Cambridge_Uni in October 2024 as part of the new exciting @MSCActions Doctoral Network @ComeInCell jobs.cam.ac.uk/job/49240/
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Please RT and share with relevant candidates! @SynCellEU @buildacell @fabriCELL_UK
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Erratum - apparently October 2024 is in the past, so we will start in October 2025 😅
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