Chemistry is a $350M early-stage firm that leads investments in founders who blend technical expertise with commercial instincts.

San Francisco
Joined October 2024
Everyone from @pmarca and @elonmusk to Pope Leo are talking about Ray Kurzweil and his astonishingly accurate predictions about technology and AI. Founding partner @EthanKurz sat down with Ray (his father), and asked the questions founders want to know. The full video is live now, for those who couldn’t join us in person. Enjoy! More events from our Elements series are coming soon.
2
1
19
7,599
Our latest Field Trip at @chemistry for AI founders & researchers - "we'll help you learn how to surf" 😜 🏄‍♂️
13
3
1
102
7,064
Chemistry retweeted
Comfy Agent is now available to everyone in Comfy Cloud. It plans, builds, and fixes ComfyUI workflows right on your canvas. We strongly believe creators shouldn’t choose between ambition and complexity. Comfy Agent is our answer. While it handles the technical part of Comfy, you can finally focus on visual craft! - It builds while you edit. It sees the assets you see. - Ask anything. Reference anything. - Create your own skills, or use the public ones. Agent in Comfy Desktop is coming soon in a few weeks. Click the link below to try Comfy Agent today ⬇️
🤖 Made with AI
135
137
87
6,781
10,248,108
Chemistry retweeted
Comfy API is live Point it at a workflow JSON and it handles the rest: → Resolves your custom nodes, models, LoRAs, and Python deps → Pins it all, ComfyUI version included, into a versioned Build → Cuts an immutable release, so what you test is what ships → Deploys as an autoscaling endpoint on RTX PRO 6000, H100, H200, or B200 Click the link below to deploy your first workflow and learn more with our blog ⬇️
192
197
90
7,852
9,613,935
Great being back on campus @BrownUniversity with @OpenAI! Brown builders are built different
6
29
1,677
Chemistry retweeted
Your favorite frontier generative media team just shipped! @ComfyUI Great job, @yoland_yan @robinjhuang and Comfy team
Comfy Router is live One API for frontier image, video, 3D, and audio models. Same model string. Same arguments. No new SDK, no new key, no redeploy. What Comfy Router gives you: → Explicit routing. You name the provider, we call that provider. It's down? The request fails there. No silent fallback. → Every job returns the provider that ran it. Log it, bill it, debug it. → Async. submit() returns a request ID immediately. The queue retries 429s and transient errors until a slot opens. subscribe() submits and polls to completion. → Batch-friendly. Queue a few hundred jobs, hold the IDs, pull results as they land. Nothing blocking on a 5-min video render. → 24h retention on inputs and outputs, then deleted. → Comfy credits. No sub, no Router fee. Providers at launch: Comfy. Runware, Wavespeed, Fal, Higgsfield. Multi-provider where the model supports it. Get Your API Key with the link below. ⬇️
2
6
22
2,504
Hitting the road this week to meet the best young builders in the Northeast. It’s going to be a whole lot of fun - come say hi! Sep 20: @conviction x OpenAI @ HackMIT luma.com/hackMIT_pizzaparty Sep 21: @IndexVentures x OpenAI @ MIT luma.com/index_openai Sep 22: @chemistry x OpenAI @ Brown luma.com/chemistry_openai Sep 22: @NEA x OpenAI in Cambridge luma.com/Nea_Openai Sep 23: @foundersfund x OpenAI @ Yale luma.com/foundersfund_openai… Sep 24: @firstround x @DormRoomFund x OpenAI @ Penn luma.com/firstround_openai Sep 25: @ThriveCapital x OpenAI @ Columbia luma.com/thrive_openai Who do I NEED to meet?!
8
4
1
56
13,061
Chemistry retweeted
.@ayaanmomin has never met a problem he didn’t want to investigate. He’s worked on antibiotic-resistant bacteria and surgical robots. When GPT-3 landed and everyone else was asking it to write poems, he was experimenting with an early version of agentic coding. That led to another question: if there were going to be many models, how would you know which one to use? So he co-founded Neutrino to route requests across them. Then the problem moved down another layer: how do you actually serve these models efficiently at scale? That took him to @FireworksAI_HQ, where he has done a little bit of everything over the past two years. Along the way, he developed the kind of familiarity with chips, infrastructure, and compute that means he can probably tell you more about AMD GPUs than you were planning to ask. Ayaan is now joining @chemistry as an investor. What ties all of this together is an instinct to keep going deeper. Ayaan doesn’t tend to stop at how something works; he wants to understand what makes it possible in the first place. That perspective feels particularly relevant right now. As AI becomes more interactive, multimodal, and embedded in the physical world, some of the most important questions are moving below the application layer: how compute is priced, which silicon is available, where the power comes from, and how all of those constraints shape what gets built next. His interests extend well beyond technology. He has strong opinions on Goya’s Black Paintings and disappears into national parks for days at a time despite being very afraid of bears (but not mountain lions). Welcome to Chemistry, Ayaan! @Mark_Goldberg_, @kshenster, @loubohan, and I can't wait to work with you!
8
2
3
23
9,266
Chemistry retweeted
One thing I omitted in talking about the disappearing middle ground for startups: founders must get the timing right in terms of momentum and theme... in other words, are you working on the 'right' problem at each stage? As the cycle time of each theme shrinks (more on this in a future post), predicting this precisely is becoming a hard moving target. @WSJVC covers this a bit this morning: wsj.com/pro/venture-capital/…
The venture market is increasingly bifurcating into two camps: massive consensus bets and contrarian companies as far from the heat as the dark side of the moon. There will be gems - and false gold - in both.
2
3
26
6,770
Congrats to @loubohan on his partner promotion at @chemistry! Curiosity is his superpower, so we decided to make him a Wikipedia page to honor the milestone. cc @kshenster @ethankurz
10
3
2
98
19,088
Chemistry retweeted
I first met @gpuemi right after YC demo day – in the amazonian expanse of Plant Cafe Dogpatch. Over a pesto tofu scramble, I could see that Emi was clearly smart, talented, passionate, and driven – but it was clear his product - an inference optimization platform for the big inference companies - just wasn’t working. I could see the tension between belief and realism even as he pitched me on his original premise, and the breakout push that was just around the corner. My honest reaction was: I hope he works on something else. Turns out a breakout was around the corner. Emi was working on something else, deftly pivoting in April of this year to a new, more expansive and adjacent vision - making inference more accessible to the masses. In so doing, he leaned into the company’s competitive advantage - moving into an exciting and demand-laden, but yes highly competitive, market that many would have found way too daunting to tackle. Emi would need that passion and drive – which was blatantly obvious in that first meeting – in order to battle it out with much bigger incumbents in the wild west of a newly emerging market. One name change later, @wafer_ai was reborn as a real-time inference cloud – taking advantage of their agents that continuously tune their inference engine, custom kernels, and hardware to each company’s exact traffic, model and SLA – in the end delivering the best performance per dollar in the market (at 30 to 50% more tokens per dollar) and climbing to #1 on the Artificial Analysis leaderboard (artificialanalysis.ai/provid…). In the process, they became the first provider to make AMD GPUs competitive with NVIDIA’s – at a materially lower cost and shorter lead time. When Wafer posted their performance numbers, customers took notice; an engineer recently texted asking for eight figures worth of throughput “by the end of the week,” not a random ‘lead’ in Wafer’s funnel - but a soon-to-be live customer. Wafer already powers Vercel, Venice, Flip, Neon Health, Brilliant, and dozens of other fast-growing AI companies, servicing 2T+ tokens a month. And it’s not unusual for me to get a random text from a CEO or CTO sharing just how Wafer’s performance gains are speeding up the underlying performance of their products. So Emi and I kept meeting up and I'm thrilled that @chemistry is co-leading their $40M Series A alongside @MarathonMP, @ycombinator and many angels. Congrats @gpuemi, @gpusteve, and team. @kshenster, @Mark_Goldberg_, @loubohan and I are excited to be on team Wafer for the road ahead.
8
13
1
60
7,213
Chemistry retweeted
The venture market is increasingly bifurcating into two camps: massive consensus bets and contrarian companies as far from the heat as the dark side of the moon. There will be gems - and false gold - in both.
26
34
29
276
181,744
Chemistry retweeted
Three approaches are racing to build robotics' data flywheel: foundation models (@physical_int @GeneralistAI @SkildAI), deployment-first (@UltraRobotics @FoundryRobotics @WatneyRobotics), full-stack (@RhodaAI @SundayRobotics @MindRobotics @WaldenRobotics). We think all three produce generational companies.
It's been a hot robot summer 🤖 Robots can now drive cars, fold laundry, and cable data centers. But the gap between 95% and 99.9% task success is the gap between a demo and a business. Our take on physical AI, and where the $40T market gets won
20
17
7
249
88,298
Chemistry retweeted
Digital AI automates cognitive work — a ~$6T opportunity. Physical AI goes after everything done with hands and machines: ~$40T. The biggest technology transition in modern history is 7x larger than the one we're living through now.
It's been a hot robot summer 🤖 Robots can now drive cars, fold laundry, and cable data centers. But the gap between 95% and 99.9% task success is the gap between a demo and a business. Our take on physical AI, and where the $40T market gets won
3
7
4
46
55,830
Chemistry retweeted
It's been a hot robot summer 🤖 Robots can now drive cars, fold laundry, and cable data centers. But the gap between 95% and 99.9% task success is the gap between a demo and a business. Our take on physical AI, and where the $40T market gets won
20
21
18
148
226,617
Chemistry retweeted
Comfy MCP is now local and open-source! The #1 ask after Comfy Cloud MCP shipped in June. Your agent sees your actual install. So every node, custom nodes included, and every model on disk. It fetches files, starts your instance, gets a workflow to the point where it runs. It is now the easiest way to help with your local Minimax H3 workflows! Cloud MCP still does everything it did. Tell your agent where a job goes, or let it decide.
79
169
48
1,362
185,881
Replying to @BrownUniversity
@BrownUniversity is quietly one of the strongest AI communities in the Bay Area. If you're an alum or student and want to be part of future events, dm me
5
4
51
2,890
Chemistry retweeted
Everyone in the Valley has a take on whether China is winning AI, robotics, and biotech. Almost nobody understands how the capital works Notes from meeting China's tier-1 investors and founders on how their venture ecosystem actually works.
81
136
69
871
363,422
Chemistry retweeted
When hiring executives, @travisk prioritizes one skill above all others: the ability to solve hard problems. "There's two things you want an executive to do. You want them to be able to organize, manage, and lead at scale. You also want them to be epic and strategic problem solvers... the best executives are the ones that are doing both well." "I have come to the conclusion over my years, that problem solving is the most important thing. If you get somebody who organizes and manages well but cannot solve a problem, they're going to be doing ridiculous stuff in a super organized way. The only constraint on your imagination is management capacity. But what is management capacity? It's really problem solving at scale."
7
46
9
557
85,469