Principal Investigator @EdinUniCVS, studying #BoneMarrowAdiposeTissue (BMAT), caloric restriction, ageing & sex differences. Also #LERU #OpenScience Ambassador
Edinburgh, Scotland
Joined September 2014
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Today we publish our latest breakthrough in understanding a question that was first asked over a century ago: why do we store so much fat in our bone marrow, and how does this impact human health?
rdcu.be/eHK31
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Finally, Mendelian randomization revealed that increased BMA at the diaphysis and hip is causally associated with osteoporosis. Therefore, decreasing bone marrow fat may be a new therapeutic strategy to prevent and treat this disease.
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Huge thanks to the many brilliant people @EdinUniMetabol, @EdinUniCVS, @EdinUniUsher and @EdinUniImaging who contributed to this work, plus our funders @The_MRC, @TheBHF, @CR_UK, and @BMA_Society for their leadership in this exciting, growing field!
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Will Cawthorn retweeted
Exciting news!
Our biobanking WG has just published a new review in @Els_BoneEndo.
This consensus review will help researchers tackle key challenges in isolating and characterizing #bonemarrowadiposetissue and #adipocytes!
Congrats to all authors👏
sciencedirect.com/science/ar…
Our recent large-scale analysis of #BoneMarrowAdiposity in the UK Biobank has been voted as Paper of the Month by @BMA_Society. I'm honoured and delighted that our work has been recognised by this growing research community!
@EdinUniCVS @EdinUniMetabol @EdinUniUsher
@BMA_society Paper of the Month "Deep learning and genome-wide association meta-analyses of bone marrow adiposity" in @NatureComms! This groundbreaking study uses #deeplearning to study #BMATby combining #GWAS in #MRI of over 48,000 people in the @UKBiobank
It's great to start 2025 with what I think is the most-important paper that my group has published so far: doi.org/10.1038/s41467-024-5…
This is the first genome-wide association study (GWAS) for bone marrow adiposity (BMA).
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Together, our findings provide insights into BMAT formation and function & provide a basis to study the impact of BMAT on human health and disease (@BMA_Society).
Huge thanks to our funders (including @The_MRC, @TheBHF, @CR_UK, @EdinburghUni) & all who contributed to this work!
I should add that it was a pleasure to work with @NatureComms throughout: very professional editorial & review process, and the attention to detail + policies for data sharing & openness have huge benefits for #ResearchIntegrity. I wish all journals insisted on this.
Will Cawthorn retweeted
Effects of seven days' fasting on physical performance and metabolic adaptation during exercise in humans
nature.com/articles/s41467-0…
