Great timing at last week’s Healthcare Executive Council dinner. Just out of stealth with a $30M Series A, @ArboretumLS presented on bringing precision medicine to common conditions & during Breast Cancer Awareness Month @OncoveryCare shared its virtual cancer survivorship model.

🎉We recently invested in 3 Healthcare Series As from amazing founders who have worked close to the problem: @ArboretumLS, precision medicine for common diseases; @vitalize_care, AI-powered hospital staffing; @AblePayHealth, flexible payments for medical bills. Congrats to all!

We've spent this year looking back on 20 years. At the end of September, we gathered at Boston’s ICA with the people who made them possible to celebrate the milestone, Kathryn Taylor Reddy's promotion to Partner, and our 100th investment. Thanks to all who joined us. 🎉 #406at20

Prior authorization is one of healthcare's biggest unsolved problems. @jeremyfriese & Humata Health built the fix: 96% first-pass approval, 83% fewer rescheduled appointments. The team & technology are now headed to @R1RCM. Proud to have backed them early. globenewswire.com/news-relea…

AI's greatest promise in healthcare isn't replacing human interactions. It's creating the efficiency that lets clinicians and patients be more human. Kathryn Taylor Reddy at the Ascension conference, on a cycle where value shifts from SaaS to workflow and execution.

Cancer survival is up: 49% five-year survival in 1975, 70% for 2015-2021 diagnoses. That's 18.6 million US survivors, and a healthcare system that largely stops at the end of treatment. @hilmoss and @OncoveryCare are closing that gap. In the Boston Globe: bostonglobe.com/2026/06/30/b…

Healthcare data plumbing isn't sexy, but increasingly it's the only thing standing between AI and a HIPAA violation. @Redox's new MCP server & AI Assistant Suite are proving it out. One beta customer did in fifteen minutes what used to take two full days. redoxengine.com/blog/redox-l…

The red-teaming research from @mindgard pushed a leading image model to bypass its own content policies. @DrGarraghan's point: safety filters aren't proof risk is handled. The teams that win keep breaking their own systems first. Covered by @BBC: bbc.com/news/articles/c802ld…

The technologies that changed everything spent years looking like they wouldn't. That's why the most interesting column in any timeline isn't 2006 or 2026. It's the one not there yet. Twenty years in, we're more interested in the next twenty than the last. #406at20

Thrilled to share the news of the close of @InStrideHealth's Series C. We've had a front-row seat since the start & in just over 4 years, InStride has helped 5,000 kids with anxiety and OCD get access to life-changing, insurance-covered treatment. fiercehealthcare.com/health-…

Couldn’t be happier to announce @ReliableAI’s launch of the public preview of its verifiable continual learning platform alongside the $6.9M Pre-Seed we led. Go, team RELAI! siliconangle.com/2026/06/10/…

Congratulations to @Greg406 on being named one of @BostonGlobe's 2026 Tech Power Players. Greg has been with .406 since 2007, nearly the beginning. Smart, diligent, thoughtful, and incredibly kind. You couldn't ask for anyone better in your corner. bostonglobe.com/2026/06/09/b…

It's always energizing when one of our founders helps move an industry conversation forward. @TechCrunch's @russellbrandom dug into #RSI, one of the most-hyped ideas in AI right now, with @me_dorx of .406 portco Disarray. techcrunch.com/2026/05/28/rs…

In 1941, Ted Williams hit .406 by swinging only at pitches in his happy zone — letting the rest go by, even strikes. 20 years ago, we named our firm after that discipline. Still swinging hard. Still in our happy zone. Thank you to everyone who's been part of it. ⚾️#406at20

Most people with PTSD never get effective treatment. @nemahealth is fixing that. 33M covered lives, 15 states, losing the diagnosis in 4-6 weeks. @PayalDivakaran & CEO Sophia Noori, MD on Breaking Health🎧: dhis.net/breaking-health-pod…

Continuing to back Nace.AI in their $21.5M round. The bet we first made is the bet now: enterprise AI value comes from small, specialized, policy-aware models and not one generalized one. 406ventures.com/insights/in-…

Huge congratulations to @jjguy, Greg Fitzgerald, and the entire @SevcoSec team on their acquisition by @AWNetworks. 🎉 You can read the announcement here: arcticwolf.com/resources/pre… @Greg406

The @nvca announced that .406’s @GrahamBrooks has been named to its Board of Directors. He will bring nearly 20 years of investing experience to this role, including over a decade leading .406’s Data + AI team. Congrats, Graham! You can read more here: bit.ly/3GyGWas

.406 Partners @Liam406 & @HoferTrip unpack a persistent challenge in mental healthcare: outdated, misaligned payment models. We’re seeing real progress, but there’s still a long way to go. Check out their candid conversation in @GoingDigitalBHT: behavioralhealthtech.com/ins…

On Breaking Health guest host & .406 Partner @payaldivakaran speaks w/Humata Health CEO Jeremy Friese, MD about how his company is solving prior auth. Friese also talks AI, regulatory landscape, pursuing entrepreneurship as an MD & more. Have a listen! bit.ly/3Z6cz1l